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Dual serotonin production
News from The Scientist 2003, 4(1):20030103-02 doi:10.1186/20030103-02
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Serotonin (5-hydroxytryptamine – 5-HT) is a key neurotransmitter with multiple roles, both in the brain and in peripheral tissues such as the gut and blood vessels. One of the rate-limiting enzymes in 5-HT synthesis is tryptophan hydroxylase (TPH) — for which no tissue specific isoforms have been identified. In the January 3 Science, Diego J. Walther and colleagues at the Max Delbrück Center for Molecular Medicine, Berlin, Germany, show that serotonin can be synthesized by a second tryptophan hydroxylase isoform exclusively in the brain (Science, 299:76, January 3, 2003).
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