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Anti-phagocytotic protein
News from The Scientist 2003, 4(1):20030106-03 doi:10.1186/20030106-03
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Group B streptococci (GBS) are the most common cause of sepsis and pneumonia in newborns. One effective antibacterial strategy in immunodeficient hosts is phagocytosis, but how virulent Gram-positive bacteria evade phagocytosis has been unclear. In the January 1 Journal of Clinical Investigation, Theresa O. Harris and colleagues at the University of Washington, Seattle, USA, show that a novel streptococcal surface protease promotes virulence, resistance to opsonophagocytosis, and cleavage of human fibrinogen (Journal of Clinical Investigation, 111:61-70, January 1, 2003).
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