Common themes in kinases :The Scientist [27/1/2003]

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by Tudor P Toma

RESEARCH ROUND-UP

Common themes in kinases

News from The Scientist 2003, 4(1):20030127-02 doi:10.1186/20030127-02

Published

27 January 2003

Serine/threonine (Ser/Thr) protein kinases catalyze the phosphoryl transfer reaction from a phosphate donor (usually ATP) to a receptor substrate. Kinases that resemble eukaryotic Ser/Thr kinases have also been identified in several bacteria, including Mycobacterium tuberculosis, and are potential antimycobacterial targets. But little is known about their structures and mechanisms of activation. In the January 27 online Nature Structural Biology, Tracy A. Young and colleagues from University of California, Berkeley, USA, show that the structure of Mycobacterium tuberculosis PknB kinase supports a universal activation mechanism for Ser/Thr protein kinases.


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