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APC protects against ischemia
News from The Scientist 2003, 4(1):20030203-02 doi:10.1186/20030203-02
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Activated protein C (APC) complements the systemic anticoagulant and anti inflammatory activities of the blood and substantially reduces mortality when administered to patients with severe sepsis. However, its exact mechanisms of action and full potential therapeutic implications have been unclear. In the February 3, Nature Medicine, Tong Cheng and colleagues at the University of Rochester Medical Center, New York, USA, show that activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and confers neuroprotective effects (Nature Medicine, DOI:10.1038/nm826, February 3, 2003).
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