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Have a HaploCHIP
Email: Jonathan Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2003, 4(1):20030310-01 doi:10.1186/20030310-01
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The majority of single nucleotide polymorphisms are found in non-coding DNA but there have been few reliable techniques to predict their functional significance. In an Advanced Online Publication in Nature Genetics, Julian Knight and colleagues at the Wellcome Trust Centre for Human Genetics, Oxford, UK, describe an approach, dubbed HaploCHIP, which uses hapolotype-specific chromatin immunoprecipitation (CHIP) to detect differences in the amount of phosphorylated RNA polymerase II (Pol II) bound to different alleles (Nature Genetics, DOI:10.1038/ng1124,10 March 2003).
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