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Bacterial drug pumps
Email: Andrea Rinaldi - rinaldi@unica.it News from The Scientist 2003, 4(1):20030509-01
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Bacterial resistance to multiple antibiotics and other drugs is a major, increasingly common problem throughout the world. Resistance is often associated with the overproduction of bacterial inner membrane proteins that are capable of extruding a variety of structurally unrelated drugs, antibiotics, and toxic compounds. In the May 9 Science, Edward Yu and colleagues at the University of California, Berkeley, disclose the structural basis of the activity of AcrAB, a constitutively expressed, major multidrug efflux system of Escherichia coli energized by proton motive force (Science, 300:976-980, May 9, 2003).
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