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Gene therapy hybrid
Email: Jeffrey Perkel - jperkel@the-scientist.com News from The Scientist 2003, 4(1):20030630-03
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Gene therapy delivery systems can either be viral or nonviral. Viruses, which offer strong specificity, high efficiency, and a natural predilection for delivering DNA into the cell and having it expressed, can also induce unintended and sometimes fatal consequences. Nonviral approaches, on the other hand, though less toxic, are relatively inefficient and nonspecific. Now, a group of Japanese researchers has blurred the lines to create a hybrid approach that they say offers the tissue specificity and efficiency of a viral approach without the harmful side effects.
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