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Cytomegalovirus cell receptor
Email: Tudor Toma - t.toma@imperial.ac.uk News from The Scientist 2003, 4(1):20030724-01
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Human cytomegalovirus (HCMV), a latent herpesvirus, can cause a severe infection in immunocompromised individuals and is also implicated in some birth defects and in coronary atherosclerosis. HCMV activates multiple cellular signaling pathways, but a cellular receptor that mediates viral entry has been difficult to identify. In the July 24 Nature, Xin Wang and colleagues at the University of North Carolina at Chapel Hill show that epidermal growth factor receptor (EGFR) is a cellular receptor required for human cytomegalovirus entry into cells (Nature, 424:456-461, July 24, 2003).
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