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Selecting damaged sperm
Email: Cathy Holding - cholding@hgmp.mrc.ac.uk News from The Scientist 2003, 4(1):20030801-01
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Three human dysmorphic syndromes result from autososmal dominant mutations in three of the four fetal growth factor receptor genes. One of these—Apert syndrome—is caused by a mutation that arises solely in the paternal gene, with increasing frequency positively correlated with increasing age. In the August 1 Science, Anne Goriely and colleagues at the Weatherall Institute of Molecular Medicine report that a mutation at this site is selected for because it confers an advantage to the individual sperm, even though the result is harmful in the developing embryo (Science 301:643-646, August 1, 2003).
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