Chronic infections impair immune response :The Scientist [22/9/2003]

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RESEARCH ROUND-UP

Chronic infections impair immune response

Email: Tudor Toma - t.toma@imperial.ac.uk
News from The Scientist 2003, 4(1):20030922-01

22 September 2003

The T-cell antigen receptor zeta (ζ) chain contains signal-transducing motifs, and its downregulation has been linked with impaired in vitro T-cell function in cancer and autoimmune and infectious diseases. However, the exact molecular mechanisms involved are unknown. In the September 21 Nature Immunology, Noemí Bronstein-Sitton and colleagues at the Hebrew University-Hadassah Medical School show that reduced ζ expression is the normal outcome of an excessive and potentially hazardous immune response (Nature Immunology, DOI:10.1038/ni975, September 21, 2003).


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