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Understanding HIV dementia
Email: Tudor Toma - t.toma@imperial.ac.uk News from The Scientist 2003, 4(1):20030923-01
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HIV can infect brain macrophages and microglia, causing neuroinflammation and neuronal death. This damage results in the neurodegenerative syndrome HIV dementia, but the molecular mechanisms that mediate the neurodegeneration have been unclear. In the September 21 Nature Neuroscience, Kunyan Zhang and colleagues at the University of Calgary show that HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor 1 (SDF-1) causes neurodegeneration (Nature Neuroscience, DOI:10.1038/nn1127, September 21, 2003).
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