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HIF-1alpha hinders mismatch repair
Email: Clementine Wallace - clementine.wallace@gmail.com News from The Scientist 2005, 6(1):20050321-01
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A newly found mechanism that promotes the appearance of mutations under hypoxic conditions is reported in the March 18 issue of Molecular Cell. In the oxygen-deprived microenvironment of certain tumors, the genetic instabilities that ensue stimulate tumor progression and metastasis.
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