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XX mouse cell instability explained
Email: Charles Choi - cqchoi@nasw.org News from The Scientist 2005, 6(1):20051024-01
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Possessing two X chromosomes can significantly reduce DNA methylation in mouse embryonic stem cells, potentially explaining why such cell lines have proven unstable in culture, scientists report online in Nature Genetics. These findings could also shed light on what genes are involved in X chromosome inactivation and why such inactivation happens, co-author Neil Brockdorff at Hammersmith Hospital in London, UK told The Scientist.
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