The International Committee of Medical Journal Editors (ICMJE)1 announced in 2004 that data from clinical trials could only be considered for publication if a trial had been registered on ClinicalTrials.gov , the United States registry for clinical trials that was started in 2000. The ICMJE said the registration deadline was September 13, 2005. 2 An analysis of registrations between May 20 and Oct. 11, 2005 found that publication is a powerful incentive to fill out paperwork, 3 with universities demonstrating the most dramatic surge in predeadline registration efforts. The 73% increase in registrations over the interval was associated with a nearly 200% increase in the number of data providers around the world (the site began including international trials in the fall of 2004).
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A Question of Quality
ClinicalTrials.gov registrations are up, but how useful are the data?
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