To hear Tony Hunter tell the story, his discovery of tyrosine phosphorylation was nothing more than a happy accident. It was 1979, and researchers had known for decades that protein kinases were involved in regulating cell growth, proliferation, and metabolism. But, as far as everyone thought, kinases phosphorylated their target proteins only on serine or threonine residues, the only modified amino acids that had been detected.
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A Phosphorylation Pioneer
Tony Hunter discovered tyrosine kinases because he was lazy - then the fun began
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