With all the hubbub surrounding microRNAs in plants and invertebrates after their discovery, it was only a matter of time before a functional role was found in mammals. In 2004, graduate student Soraya Yekta, and Whitehead Institute for Biomedical Research member David Bartel found a role for microRNA miR-196 in HOXB8 regulation in mice. 1 Naturally, it was assumed such a mechanism would exist in mammals. But, says Victor Ambros, microRNA pioneer at Dartmouth Medical School, "Nothing about microRNAs is particularly expected, so it really is important to actually find these situations."
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MicroRNAs assume a developmental role
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