While much research focuses on T and B cells entering lymphoid organs, Jason Cyster says he's more curious about how they get out. He and colleagues at the University of California San Francisco found a clue to lymphocyte escape, both from the thymus and secondary lymphoid organs, in an immunosuppressant drug, FTY720. The drug sequesters T and B cells in lymphoid organs and is known to interact with sphingosine-1-phosphate (S1P) receptors.
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A lymphocyte makes its exit
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