The Nucleosome Untangled :The Scientist [2006-05-01]


	The article you are attempting to read is Premium content which is only available to our online subscribers.

Subscribing to The Scientist is easy and inexpensive.

And you can choose from many options. Try us out with an online day pass starting at only $4.95. Or, get it all with unlimited online access to The Scientist Archive and door-to-door delivery of our monthly print magazine.


	The Scientist also offers site licenses to institutions and organizations. When your librarian adds The Scientist to the library's collection, you can get unlimited online access through your place of work or study. Recommend The Scientist today

	BY BRENDAN MAHER ARTICLE EXTRAS Related Articles: Is It a Code: The DebateSteven Henikoff and Bryan M. Turner debate if there really is a histone code.

The Nucleosome Untangled Roughly two meters of DNA gets packed into every cell nucleus in the human body. In addition to stuffing all that information into a sphere 3 to 10 microns across, the proteins that perform this task must also ensure that in each cell certain genes are constantly transcribed, while others lie ready, and other regions remain dormant, practically inaccessible. Within this cramped, chaotic space, an