How to predict epistatic gene interactions

When combined, the effects of mutations in different genes often deviate from what would be expected by looking at them separately. Researchers at the University of Val￨ncia in Spain have shown that an organism's genomic complexity may predict these epistatic gene interactions.1 It is a "fascinating new synthesis of published experiments," writes Faculty of 1000 member Richard Lenski of Michigan State University, adding that it is "sure to stimulate empirical and theoretical research for years to come."


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