Table: Selected TLR Ligands in Clinical Trials Product Target Manufacturer Condition Phase Intervention Status CPG7909 TLR9 Coley Pharmaceutical Group Lymphoma I/II CpG injections and radiotherapy http://www.clinicaltrials.gov/ct/show/NCT00185965 Ongoing ﾠ ﾠ Coley/Pfizer Metastatic breast cancer, renal cell cancer, T-cell lymphoma, non-small cell lung cancer, melanoma I or II CpG injection with or without chemotherapy http://www.clinicaltrials.gov/ct/show/NCT00043407 http://www.clinicaltrials.gov/ct/show/NCT00043420 http://www.clinicaltrials.gov/ct/show/NCT00070629 http://www.clinicaltrials.gov/ct/show/NCT00070642 Ongoing and completed ﾠ ﾠ ﾠ Malaria I Malaria vaccine with and without CpG 7909 http://www.clinicaltrials.gov/ct/show/NCT00320658 Recruiting CPG10101 TLR9 Coley Pharmaceutical Group Hepatitis C II Pegylated interferon plus ribavirin with or without CPG 10101 in hepatitis C patients http://www.clinicaltrials.gov/ct/show/NCT00277238 Recruiting ﾠ 1018 ISS TLR9 Dynavax Allergy II ISS conjugated to ragweed allergen given to patients with allergic rhinitis http://www.clinicaltrials.gov/ct/show/NCT00346086 Completed ﾠ ﾠ ﾠ B-cell follicular lymphoma II ISS given in conjunction with Rituxan http://www.clinicaltrials.gov/ct/show/NCT00251394 Recruiting ﾠ ﾠ ﾠ Metastatic colorectal cancer I ISS in combination with irinotecan and cetuximab http://www.clinicaltrials.gov/ct/show/NCT00403052 Recruiting ﾠ ﾠ ﾠ Hepatitis B II ISS with hepatitis B surface antigen compared with commercial hepatitis vaccine (completed in 2004; phase III trial underway in Asia) Completed   Rate this article Currently 1.33/5 1 2 3 4 5 Rating: 1.33/5 (6 votes ) Comment on this article