Supplement: Drugs, Diet, and Lupus :The Scientist [2007-05-01]


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Supplement: Drugs, Diet, and Lupus One of the best examples of a gene-environment interaction in autoimmunity involves instances in which certain drugs produce a lupus-like syndrome in genetically susceptible individuals. It turns out that people who carry a variant of the N-acetyltransferase-2 gene, so-called slow acetylators, do not metabolize the drugs procainamide and hydralazine very well. Thus, they are predisposed to lupus