Remodeling the Model T

A new lineage of T helper cells shakes up an old paradigm.

In the classic model of immune system response, naive effector T cells differentiate into two kinds of cells that combat antigens. T helper type 1 (T_H1) cells clear intracellular pathogens, while T helper type 2 (T_H2) cells control certain parasitic infections. In 2005, Casey Weaver's team at the University of Alabama at Birmingham identified a third class of T helper cell that produces the cytokine interleukin 17 (IL-17) in response to autoimmune tissue injury, which they named T_H17 cells.1

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