In "The skinny fat ," 1 Bruce Spiegelman tells us he is working with the Broad Institute to screen every FDA-approved drug for possible effects on a "brown-fat molecule," PRDM16, reasoning that drugs that act on this molecule might also trigger weight loss. Wouldn't it be smart to determine whether any of these FDA-approved drugs are associated with significant weight loss before starting the screening campaign at the molecular level for PRDM16?
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