Contributors

As a young assistant professor at the University of Washington in the late 1980s, Randall Moon stole into his quiet lab during a holiday break to run one experiment. He had a hunch that the INT-1 gene played a crucial role in development. It turned out he was right: In that one experiment he discovered a critical signaling pathway and the direction of his career for the next 15 years, which he writes about in "WNTer wonderland." "To go from asking a dumb question about why injecting this RNA could turn a frog into a two–headed frog, to having potential therapies for a wide range of diseases based on understanding that pathway, is a nice research arc," says Moon, now an HHMI investigator and professor of pharmacology at the University of Washington in Seattle.

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