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Want a better way to submit grants electronically? Find out the pros and cons of the most widely-used programs.

It wasn't so long ago that Scot Wolfe, assistant professor at the University of Massachusetts Medical School, needed to check every page of his nearly 70-page National Institutes of Health grant application, to ensure that the copier hadn't smudged any of the required five copies. Then he would pack up the applications and send them by FedEx to Bethesda, Md. "I've blocked that out a little bit," says Wolfe.

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