Middling Measures

As researchers busily catalog the sequence variations across human populations in the HapMap Project, instrument developers are ramping up the throughput on platforms assessing single nucleotide polymorphisms (SNPs). New technologies can sequence millions of reactions on a single chip. With platforms becoming ever more powerful, sequencing experiments that used to be considered high-throughput - in the hundreds of SNPs - are starting to fall into a vast middle ground where the technology falls short.