With roughly 1,000 different members, G-protein-coupled receptors (GPCRs) are the largest family of proteins coded by the human genome. Involved in sensing a panoply of physiological and environmental signals, including hormones, neurotransmitters, odorants, tastes and light, GPCRs are the targets of a pharmacopeia of drugs, from beta blockers to antihistamines. Until recently, however, high-resolution crystal structures were known for only the light receptor rhodopsin.
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B2AR Laid Bare
A snapshot of the adrenaline target opens the door to more high-resolution, 3-D crystal structures.
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