PAPERS TO WATCH

Cell division rewinds

The cell cycle is generally considered a one way ticket to division. Recently, through chemical and genetic trickery, Gary Gorbsky at the Oklahoma Medical Research Foundation and colleagues reversed the process.1 They first triggered premature mitotic exit in Xenopus and human cells using inhibitors of cyclin-dependent kinase 1 (Cdk1). This normally also degrades the Cdk1 activator cyclin B. If the researchers next prevented cyclin B degradation or expressed non-degradable cyclin B and then washed out the Cdk1 inhibitors, the cells returned to metaphase. "You can actually see mitosis go backwards," says Faculty of 1000 member Claire Walczak at Indiana University in Bloomington.


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