Even the simplest biochemical pathway - ligand, receptor, intracellular messenger, output - is far more complex than a simple back-of-the-envelope sketch. Signaling molecules have multiple kinase and phosphatase regulators, and gene promoters can be simultaneously influenced by both positive and negative transcription factors. Ligands, of course, are themselves subject to myriad control systems.
What Can Systems Biology Do for You?
Four computational modeling strategies and the data that build them.
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