By Karen Hopkin
From Buckets of Banana Mash
Genizon CSO Tim Keith's cautious but rigorous approach has made it possible for companies to separate real data from noise.
In the late 1990s, Tim Keith was the leader of a team at a company called Genome Therapeutics that discovered ADAM33, the first gene to be associated with asthma. The milestone paper, published in Nature in 2002, "is probably one of the most widely cited papers in the asthma field," says Stephen Holgate of the University of Southampton, who supplied DNA samples collected from families in the United Kingdom. Although no drugs have yet emerged from the pipeline, Schering Plough (Genome Therapeutics' corporate partner in the ADAM33 discovery) has been working on turning the findings into novel therapies for the treatment and prevention of the disease.
