The Scientist : NewsBlog Print: Venter makes synthetic chromosome... or does he?
The Scientist: NewsBlog:
Venter makes synthetic chromosome... or does he?
Posted by Alla Katsnelson
[Entry posted at 8th October 2007 08:51 PM GMT]

Rumors of J. Craig Venter's achievements in creating artificial life are again circulating in the press - the Guardian reported this weekend that Venter has successfully made a fully synthetic chromosome, dubbed Mycoplasma laboratorium. The chromosome reportedly consists of 381 genes, and in total contains 580,000 nucleotide base pairs.

In a study published this June, Venter (who is a member of The Scientist's editorial board) and colleagues switched two closely related species of bacteria by transplanting their genomes. This transplantation step would be needed to activate synthetic chromosomes as well.

So far, however, the new work is not accompanied by a peer-reviewed publication. Venter "is poised to announce" the discovery in the next couple weeks, according to the Guardian article, and possibly even today, at the J. Craig Venter Institute's annual meeting.

The institute's media contact, Heather Kowalski, did not return a phone call for clarification, but Nature's news blog, The Great Beyond points to a report in AFP, in which Kowalski declined to confirm the breakthough. "We have not achieved what some have speculated we have in synthetic life," Kowalski apparently told AFP. "When we do so there will be a scientific publication and we are likely months away from that."


 

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An Optimistic Approach
by Leon C

[Comment posted 2007-10-10 20:10:28]

Such an advancement in the biological field should be revered rather than feared.

Despite being able to do harm with such an improvement, who's to say that there won't be scientists who want to benefit humankind by applying this newly gained knowledge in areas unrelated to chimeras? Those who want absolutely nothing to do with bioterrorism? By accounting for the minority of scientists who may potentially use this new information purely for the sake of engaging in bioterrorism, one dismisses the fact that not all scientists want to dominate/destroy the planet. The many science-fiction stories involving a mad scientist with the intent of creating havoc upon the world presents only one out of the many possibilities for which biological advancements may be used for. For this reason I believe it is safe to say that for every "evil" scientist out there in the world, there will be just as many - if not more - scientists who prefer to do "good."

There will always be advantages and disadvantages in developing these advancements. Take drugs as an example. Needless to say, drugs can easily be taken for non-medicinal usages, i.e. for purposes that potentially endanger one's well-being. This is a clear representation of how developments in science can lead to disastrous consequences. However, in the end, one must ask: What about the many thousands or even millions of lives saved everyday by these drugs? Do we simply disregard these people and allow them to perish or do we push on and advance mankind's knowledge of science? Again, there will always be a numerous number of those who apply these drugs properly versus the minority of those who use the drugs for unhealthy purposes.

Venter is not necessarily inventing a chimera with this upcoming advancement in molecular biology. If he is, in fact, intending to synthesize a chimera for furthering bioterrorism, there will nevertheless be scientists who desire to perform the opposite by synthesizing forms that will be capable of aiding humankind, rather than harming. The ?dark? days of molecular biology will never truly be dark as long as there are those who understand that there must be ?light? for darkness to exist; those are the ones who painstakingly endeavor to further scientific knowledge and to benefit the rest of mankind through such accomplishments.





Back to the future with Venter
by Anita Allen, South Africa.

[Comment posted 2007-10-09 03:36:48]

Remember all those paintings of weird creatures with human bits and pieces attached to all sorts of things and vice versa? Did people paint those chimeras because some one somewhere saw them however briefly? Or were chimeras conjured out of the imagination? Either way, Craig Venter is creating his own chimera, which he is about to set loose on the world - and proud of it because he is doing it all in the public interest.

This goes beyond practicing biochemistry without a licence, to is there no where, someone who can put Venter in jail for calling it the Human Genome Project, when it is 75% his DNA - the rest being contributed by 2 laboratory assistants, and then the program was designed to explicitly screen out all regulatory genes, focussing only on structural ones which as it turns out comprise a mere 2% of the human genome, according to ENCODE (Encyclopedia of DNA Elements; Nature 13 June 2007) which confirmed that structural genes are only minor players in genetic processes.

Undeterred, Craig is pioneering ahead cobbling together his laboratory construct involving what he knows not but he aspires to godhood?

The guts has been ripped out of the understanding of "gene" and its role in genetic processes. It fulfills what others have warned for along time is a road wrong taken.

These are dark days indeed for science. Molecular biology is in a mess - and Venter's chimera won't be the first - the horror is molecular biology is indistinguishable from bioterrorism.








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