In my web resources (http://www.semeioticabiofisica.it) I describe an original biophysical-semeiotic method that is easy to apply at the bed side. This method is also reliable in recognizing Alzheimer's Disease, even in initial and/or symptomless stage (See an appropriate document at the application page of my web site). In such neurodegenerative disorder, in my opinion, we must aim early ?clinical? diagnosis, possibly soon after the disease on-set, or better in the so-called ?pre-pathological? phase (i.e. at the disease ?real? risk). The diagnosis must be necessarily ?clinical?, and GPs (whom these patients visit first) have to recognize the initial or ?pre-pathological? stages. These stages are characterized functionally by modification of Neuronal and Cerebral Evoked Potentials, and nowadays can be assessed at the bed-side by means of Biophysical Semeiotics (see Cerebral Tumour application of the method at http://www.semeioticabiofisica.it). In healthy, from the microcirculatory point of view, during stress test both vasomotility (chaotic-deterministic oscillations of cerebral arterioles) and vasomotion (chaotic-deterministic fluctuations of nutritional capillaries and post-capillary venules) particularly in hippocampus, pre-frontal and parietal cerebral regions are maximally activated. On the contrary, individuals with a family history positive for Alzheimer?s disease (and, of course, in patients in the first stages of the disease) under identical conditions have a particular form of microcirculatory activation, characterized by increased vasomotility and decreased vasomotion. I termed this condition "dissociated type". In brief, the flow- and flux-motion in the cerebral microcirculatory bed appears to be clearly decreased, possible due to the dangerous phenomenon of the so-called "microcirculatory blood-flow centralization". I hope that sucha as clinical method could suggest also a new way in the treatment.