On The Life Sciences Scene

Sleep And Memories, Blueprints And Organisms

A. "Sleep makes room for memories"

http://www.sciencenews.org/view/generic/id/38692/title/Sleep_makes_room_for_memories
Sleep erases old memories to make way for new learning...sleep changes the biochemistry of the brain...

B. Sleep neither erases nor inscribes memories

Sleep does not change the biochemistry of the brain. Memories are inscribed in the brain, and maintained or erased, in genetic biochemical processes.

Again and again. Genes are organisms, even as now interdependent members of their genome communal cooperative, they were born with the environmental habit and need to sleep.

The need to sleep is innate in genes, as evidenced by the Circadian Rhythm. It was daylight's energy that trans-phased the pre-alive RNA oligomers into individual living polymers, the primal genes, and it was daylight's energy that continued being the ONLY source of energy for the early genes, organisms, in the pre-biotic Earth surface. And this state of affairs persisted along the course of evolution of genes into communal cooperative genomes, with chromosomes enclosed in cells and later also in nuclei. It took many many following years for Earth to start evolving its biosphere and to furnish to its life alternative energy sources, as life evolved the capability to exploit the additional types of energy.

Organisms' "biological clock" is thus an inherited matter, an innate characteristic.

C. Sleep does effect the functionality of genes and of chromosomes

On pre-biotic Earth the functionality of the primal genes, and chromosomes, was decreased or impaired at daylight's energy switch-offs. This is life's innate phenomenon that carried into multicelled organisms.

D. Genes-genomes are NOT "DNA sequences, materials, genetic blueprints..."

It is necessary to overcome a reflective resistance to conceive certain polymers as living, as organisms. However, the plain simple fact of life is that genes are organisms, the primal organisms of Earth, the LIFE of Earth. All other organisms evolve and live temporarily to promote and maintain the genes, to promote and maintain the temporary store of energy by Earth's biosphere.

The common sad observation is that the science establishment and its publications refer to, and comprehend, genes-genomes organisms in pre-Copernicus pre-Galileo term "genetic codes"... with stubborn insistence on seeing the naked emperor's new clothes, on seeing genes-genomes not as the organisms they obviously are but as "DNA sequences, genetic materials, genetic blueprints..."

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Again And Again: Understanding Sleep

A. New research sheds light on fly sleep circuit

http://www.eurekalert.org/pub_releases/2008-11/bu-nrs112508.php

Brandeis scientists research fly sleep to advance understanding of human sleep and its disorders

B. Sleep And Memories, Blueprints And Organisms

http://www.the-scientist.com/community/posts/list/80/122.page#1106

The common sad observation is that the science establishment and its publications refer to, and comprehend, genes-genomes organisms in pre-Copernicus pre-Galileo term "genetic codes"... with stubborn insistence on seeing the naked emperor's new clothes, on seeing genes-genomes not as the organisms they obviously are but as "DNA sequences, genetic materials, genetic blueprints..."

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Unbelievable: A Potentially Universal Mechanism Of Aging!

A. Latest News: A Potentially Universal Mechanism Of Aging
http://www.eurekalert.org/pub_releases/2008-11/hms-ria111908.php

"Researchers have discovered that DNA damage decreases a cell's ability to regulate which genes are turned on and off in particular settings. This mechanism, which applies both to fungus and to us, might represent a universal culprit for aging. "

B. Universal mechanism of aging has been explained earlier...

Predicting Chronological And Physiological Age Is Complicated
http://www.the-scientist.com/community/posts/list/60/122.page#1077

Genes Are Organisms And Age, Too...
http://www.the-scientist.com/community/posts/list/40/122.page#900

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Prions, Mad Cow, CJD: Disease Mechanism

A. "Mouse model of prion disease mimics diverse symptoms of human disorder"

http://www.eurekalert.org/pub_releases/2008-11/cp-mmo112008.php

"The research, Cell Press Nov 26 2008,journal Neuron, provides exciting insight into the mechanism of the disease."

"This new model allows in-depth analysis of the disease mechanisms".

B. The mechanism is least-energy protein-folding...

"Prion Proteins, 2008 "
http://www.the-scientist.com/community/posts/list/122.page#348

"Neurodegenerative Diseases, Prions, And Life Genesis"
http://www.the-scientist.com/community/posts/list/20/122.page#542

"Ease-of-kill is test of lifeness"
http://www.the-scientist.com/community/posts/list/20/122.page#549

Degenerating proteins replications are phenomena of serendipitous occurrences of "favourable-energy-balance" proteins foldings, involving specific protein-forming-folding-enzymes and enzymes-protein complexes.

Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Epigenetic Heredity Comprehension Advanced

A. Epigenetic heredity, beautiful work and findings

http://www.eurekalert.org/pub_releases/2008-11/cshl-csd112608.php

Scientists found a new way in which 'epigenetic information' is inherited. A class of small RNAs inherited from the mother determines offspring’s 'fertility trait'.

"It remains to be seen whether this mechanism of epigenetic inheritance is found in organisms other than fruit flies. Small mother's RNAs are probably deposited in oocytes of every animal, Hannon hypothesizes."

In hybrid dysgenesis, transmission of *transposon by a parent induces sterility in the offspring, unless the offspring also inherits a factor that suppresses the transposon and maintains fertility. Since the phenomenon had only been seen when the transposon-transmitting parent was male, the suppressing factor was thought to be maternally transmitted, but it was never identified until now.

Hannon's team has now found that the stockpile of maternally derived proteins, RNA, and nourishing raw material in developing fruit fly oocytes, or egg cells, also includes piRNAs. And these maternally deposited piRNAs prove to be essential for mounting a silencing response against the culprit transposons.

*(A transposon is a mobile segment of DNA that serves as an agent of genetic change. Some transposons move by 'cut and paste' into new locations. Others stay put but 'self- copy and paste' themselves elsewhere in the genome.)

B. About epigenetics

Epigenetic = relating to gene functional changes that do not involve changes in the DNA sequence.
Example: methylation, methyl groups attached to DNA.

http://www.sciencedaily.com/releases/2008/06/080624174849.htm

The rates of change of the extent of epigenetic marking and activity are genetically phenotypic, varying with age similarly within family members, and "could be an important link between environment, aging and genetic risk for disease".

BTW this age-and-epigenetics work, IMO, enhances my conception of the nature of life
"Life's Manifest"
http://www.the-scientist.com/community/posts/list/112.page#578

C. The piRNAs work is outstanding, yet could be more if gene-genome realized to be the organisms they are

One day, maybe yet in the 21st century, science will look back with amused disbelief at old terms and concepts like "letters of the DNA sequence" and "epigenetic information", in regards to living and aging, genes-genome organisms..

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

PS:

Another recent work demonstrates beautifully effect of tinkering with a single gene

Minus one gene, male mouse is Mr. Mom
http://www.sciencenews.org/view/generic/id/38719/title/Minus_one_gene%2C_male_mouse_is_Mr._Mom
The goose becomes the gander, and vice versa.

Male mice...become doting parents and accomplished homemakers when a gene that senses pheromones
is removed from the region of their brain...

Removing the Trpc2 gene from male mice made them act like females, whereas females rendered to lack the Trpc2 gene act like males...

Fwd by DH

Peer Review And Innovation In Science

A. "The new face of peer review", in "Funding Opportunities and Advice" forum, at
http://www.the-scientist.com/community/posts/list/298.page

refers to "changes to the peer review process".

B. However, "peer review process" is the least disturbing aspect of "peer review" in science

Samples of factual observations of other negative aspects of peer review in science:

- http://www.digibio.com/archive/SomethingRotten.htm
"A U.S. Supreme Court decision and an analysis of the peer review system substantiate complaints about this fundamental aspect of scientific research. Far from filtering out junk science, peer review may be blocking the flow of innovation, and corrupting public support of science."

- "Peer review stifles innovation, perpetuates the status quo, and rewards the prominent. Peer review tends to block work that is either innovative or contrary to the reviewers' perspective."

C. "Peer Review" is, factually, a tool of a "Subversive Activities Control Board"

The most revolting corrupt aspect of peer review in science is its exploitation by the Science Establishment to tightly clamp its political and financial omni-everything rule and control, including stifling of any shred of scientific innovation.

D. The corruption is not inherent in the tool, but in the nature of the Science Establishment

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

The peer review process is but a tool of the Establishment. The corruption is not inherent in the tool, but in the nature of the Science Establishment.

As long as Science and Technologhy are considered and handled, conceptually and administratively, as one realm and one faculty this corruption cannot and will not be overcome. This conception and attitude is THE CORRUPTION OF SCIENCE BY THE 21st CENTURY TECHNOLOGY CULTURE.

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

When Is God-Science Discussable Scientifically

Re "God and Evolution Can Co-Exist, Scientist Insists"
http://www.the-scientist.com/community/posts/list/304.page#1124

- Is there/what is, in the quoted article, a definition of the article's "god" ?

- Specifically, is the article's "god" defined as a human artifact, or not ?

If "god" is defined/understood to be a human artifact - regardless of reasons, purposes, implications, consequences - the subject "god-science" is scientifically discussable.

If "god" is not defined/understood to be a human artifact, its concept is a human virtual reality artifact experienced only through sensory stimuli, and "god-science" is not scientifically discussable. Furthermore, in this case preoccupation with this subject within a scientific frameworks contributes to corrosion and corruption of science and scientism by manifesting or implying acceptance of virtual reality as reality.

"Evolutionary Biology Of Culture And Religion"
http://www.the-scientist.com/community/posts/list/20/122.page#492

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Age-Related Impairments And Gene-Genome Aging

A. Researchers identify gene in age-related hearing loss

http://www.eurekalert.org/pub_releases/2008-12/ttgr-hei120108.php

http://hmg.oxfordjournals.org/cgi/content/abstract/ddn402

"Age-Related Hearing Impairment (ARHI), or presbycusis, is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors." "... these data indicate that common alleles of GRM7 contribute to an individual's risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity."

Excitotoxicity = Neuronal injury caused by excessive release of excitatory neurotransmitters, glutamate and aspartate, causing damage to nerve and glial cells, occuring in diverse neurologic diseases that may be acute.

It is the overexpression of glutamate that causes damage to the inner and outer hair cells in the inner ear leading to age-related hearing loss.

B. What is "interaction between environmental and genetic factors"

"ARHI is a complex disease caused by an interaction between environmental and genetic factors."

In my plain commonsensical mind "interaction between environmental and genetic factors" is a description of organism's "aging". And in my boy's-like view of the emperor's new clothes the aging is of the genes-genome involved, as genes are life's primal organisms and their genome association is life's 2nd stratum organisms, and genes and genomes age as we age, and we age as a result of the aging of our genes and genomes...

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Renovate Western Culture, Separate Science From Technology
Separate Them Conceptually And Administratively
21st C2ntury Economy Collapse Is Collapse Of Technology Culture
Enhance Public's Science Information-Awareness

A. Science Reporting Fallout
http://www.sciencenews.org/view/generic/id/39060/title/Science_Reporting_Fallout
Newspaper cutbacks are being linked to diminished science reporting.

- Baltimore Sun: " a quick update to yesterday’s story about the epidemic downsizing of U.S. newspaper staffs"...

- Doing ‘more with less’ has degenerated to doing less with less. Science and environment stories are often shortened substantially to meet with tightening space constraints, or they don’t make it into print at all.

- No matter how you spin it, that can’t be good for ensuring an informed electorate. What’s more, you know that with the deep job cuts occurring in newsrooms across the country, the Sun’s approach can hardly be unique...

B. CNN downsizes science team
http://www.sciencenews.org/view/generic/id/39025/title/CNN_downsizes_science_team
The move and timing for greatly restructuring science-and-environment coverage at the nation's all-news cable giant are perplexing.

According to a prepared statement issued by the network, “We want to integrate environmental, science and technology reporting into the general editorial structure rather than have a stand alone unit. Now that the bulk of our environmental coverage is being offered through the Planet in Peril franchise . . . there is no need for a separate unit.”

C. Since the 1920s technology development has been THE TOOL of capital formation

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

Since the 1920s technology development has been THE TOOL of capital formation and accumulation, together with their inherent social and societal values, attitudes and life style and even together with their inherent individual and societal-social ethics.

The technology culture has been corrupting the status of science and has relegated science, the banner and hope of human enlightenment and rational evolution, to the file of quaint items. This process has been and is being perpetrated with the dedicated cooperation of the politically entrenched Science Establishment.

As long as Science and Technologhy are considered and handled, conceptually and administratively, as one realm and one faculty this corruption cannot and will not be overcome. This conception and attitude is THE CORRUPTION OF SCIENCE BY THE 21st CENTURY TECHNOLOGY CULTURE.

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Science Creed Manifest (SCM)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=142

Placebos
Pavlov is smiling

A. Imagination Medicine

http://www.sciencenews.org/view/feature/id/39046/title/Imagination_Medicine
Brain imaging reveals the substance of placebos. Expectation alone triggers the same neural circuits and chemicals as real drugs.

"It all boils down to expectation. If you expect pain to diminish, the brain releases natural painkillers. If you expect pain to get worse, the brain shuts off the processes that provide pain relief. Somehow, anticipation trips the same neural wires as actual treatment does.

Scientists are using imaging techniques to probe brains on placebos and watch the placebo effect in real time. Such studies show, for example, that the pleasure chemical dopamine and the brain’s natural painkillers, opioids, work oppositely depending on whether people expect pain to get better or worse. Other research shows that placebos can reduce anxiety."

B. Recommended background info:

http://www.cerebromente.org.br/n09/mente/pavlov_i.htm
http://www.cerebromente.org.br/n09/mente/placebo1_i.htm
http://thjuland.tripod.com/placebos.html

The concept of a placebo comes from medieval times, when professional mourners were paid to stay by the bedside of. deceased person, reciting a psalm beginning "Placebo Domino..." or "I shall please the Lord." "Placebo" gradually became the word used for the paid mourner, whose grief was, in fact, false.

Fwd'ed by
Dov Henis

Why Pavlov Is Smiling In 2008

The GGRPVR Chain:
Genes, God, Religion, Placebo, Virtual Reality.

A. Imagination Medicine

http://www.sciencenews.org/view/feature/id/39046/title/Imagination_Medicine
Brain imaging reveals the substance of placebos. Expectation alone triggers the same neural circuits and chemicals as real drugs.

"It all boils down to expectation. If you expect pain to diminish, the brain releases natural painkillers. If you expect pain to get worse, the brain shuts off the processes that provide pain relief. Somehow, anticipation trips the same neural wires as actual treatment does.

Scientists are using imaging techniques to probe brains on placebos and watch the placebo effect in real time. Such studies show, for example, that the pleasure chemical dopamine and the brain’s natural painkillers, opioids, work oppositely depending on whether people expect pain to get better or worse. Other research shows that placebos can reduce anxiety."

B. Placebos: some background info

http://www.cerebromente.org.br/n09/mente/pavlov_i.htm
http://www.cerebromente.org.br/n09/mente/placebo1_i.htm
http://thjuland.tripod.com/placebos.html

The concept of a placebo comes from medieval times, when professional mourners were paid to stay by the bedside of. deceased person, reciting a psalm beginning "Placebo Domino..." or "I shall please the Lord." "Placebo" gradually became the word used for the paid mourner, whose grief was, in fact, false.

C. Life's Manifest

http://www.the-scientist.com/community/posts/list/112.page#578

Genes are the primal, first stratum, Earth's organism.

D. Of Science and Religion

http://www.physforum.com/index.php?showtopic=18243&st=0&#entry267674

E. So why is Pavlov smiling in 2008?

Pavlov demonstrated effecting placebo phenomena in multicelled organisms by manipulation of their drives-reactions. Now placebo phenomena are demonstrated in the multicelled organism's genes and genomes, in our primal first stratum and 2nd stratum base organisms...a very good reason to smile.

Now an interesting chain is exposed to our view, the GGRPVR Chain, the Genes-God-Religion-Placebo-Virtual Reality chain, a most intriguing cultural evolution chain...

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Culture And Intelligence Of
Living And Inanimate matter

Re
http://www.the-scientist.com/community/posts/list/20/24.page#1199
What is intelligence?

A. Over and over again

"Intelligence, like every "specific" physical property (f.e. specific weight or heat etc.,) is a specific cultural phenotype characteristic. Plain science....

The core (wordnet.princeton) definition of "intelligence" is "the ability to comprehend, to understand and profit from experience". These surviving abilities are different for the different phenotypes within a genotype, therefore each phenotype has its own meaning of "intelligence".

Intelligence is to culture approximately as essential amino acids are to proteins. Culture evolves in response to circumstances by use of intelligence and to the extent and scope feasible by the extent and scope of intelligence."

B. Biological culture is a biological entity.

It is an elaboration-extension of the cell's manipulation beyond its outer membrane. It has been selected for survival of genes and genomes by means of manipulating-adjusting the cell's outer circumstances, in addition to the cell's outer membrane which was selected much earlier for controlling the inner cell's circumstances.

C. But organic and biological, as well as all inanimate matters,

are all cosmic matters consisting essentially of energy, therefore - strange as it sounds but definitely factual - all and each matter display culture and intelligence, i.e. each displays a unique mode of response to its environment and circumstances (culture) in its unique mode-rate-manner (intelligence).

How much simpler and clearer can culture and intelligence be comprehended and defined?

Respectfully,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Myopics, Update Your Darwinian Evolution Conceptions

A. From "Gene could drive species separation"

http://www.sciencenews.org/view/generic/id/39279/title/Gene_could_drive_species_separation

"A newly identified gene in fruit flies may drive the creation of new species, revealing how internal genetic environments may be just as important as external factors when it comes to speciation. The new work lends evidence to a hotly debated idea in evolutionary biology.

“Conventionally, evolutionary biologists thought that speciation involved adaptation to the external environment, but these results suggest that adaptation to the internal genomic environment also sometimes plays a role,”

B. From "Culture, A Ubiquitous Biological Entity", one of tens of related postings during the last ten years

http://www.the-scientist.com/community/posts/list/98.page;jsessionid=AE07D240319E7648DDC9073A7AF8BBE3#401

Culture is the universal driver of genetic evolution.

The major course of natural selection is not via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased genes replication routes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third stratum multicells organism or monocells community to their second and prime strata genome-genes organisms.

C. Myopics, Update Your Darwinian Evolution Conceptions!

How many years and how many tens of internet postings will it take until you notice and read and assimilate the Updated Darwinian Evolution Conceptions.

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Genetics, Culture, Social Learning, Environment,
Mumbo Jumbo And Evolution

A. From "Dolphins wield tools of the sea"

http://www.sciencenews.org/view/generic/id/39219/title/Dolphins_wield_tools_of_the_sea
A long-term study of dolphins living off Australia's coast finds that a small number of them, mostly females, frequently use sea sponges to forage for fish on the ocean floor.

- "Not everyone regards such food-gathering tactics as purely the products of social learning or culture. Genetic traits and habitat characteristics may influence how animals forage as much as or more than any cultural traditions, argued Kevin Laland and Vincent Janik, biologists at the University of St. Andrews in Scotland, in a 2006 paper."

- "Further research needs to tease out the effects of genes, environments and culture on sponge-assisted foraging by bottlenose dolphins, comments evolutionary geneticist Michael Krotzen of the University of Zurich, who studies the social behavior of bottlenose dolphins and orangutans. “Dolphins are highly intelligent and are prime candidates for social learning in the wild,” he says"

B. Mumbo-jumbo and life's evolution

Culture (yes, and also intelligence...) is a ubiquitous trait in the inanimate AND animate realms. For life, culture is THE driver of genetic evolution.

A "Tease Out" treatment of a package of genetics, culture, social learning, and environment in regards to behaviour of an organism is a mumbo-jumbo, a pseudoscientific gibberish. Culture is the sum total of behaviour in response to circumstances-environments; the behaviour evolves as enabled by intelligence, and drives and dictates the genetic evolution. Plain and simple.

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Cellular Aging?
Complexly Instrumented Spacestations Accumulate Damage Over Time

A. From "Theories about human cellular aging supported by new research"

http://www.eurekalert.org/pub_releases/2008-12/asfc-bta111908.php

"Research presented at America Society for Cell Biology conference.

Aging yeast cells accumulate damage over time, but they do so by following a pattern laid down earlier in their life by diet as well as the genes that control metabolism and the dynamics of cell structures such as mitochondria, the power plants of cells."

B. Complexly instrumented spacestations accumulate damage over time,

and their residents, too, age and accumulate damage over time. Yes, the functionality of the stations' residents and of their intruments and equipment is impaired with age. Wonder why?

The reason for the impairment with age of the highly active instrumented-equipped stations and their residents is that they "follow a pattern laid down earlier in their life by diet as well as by the residents who control metabolism and the dynamics of the stations' structures such as mitochondria, their power plants."

C. Enough. Cells are NOT organisms, and genes-genomes are YES organisms.

Refresh your conceptions and comprehensions and attitudes and research plannings and peer-reviewings. Let your science evolve...

Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

On Strange Concepts And NeoNeoDarwinian Evolution

A. On my strange concepts

I have recently received messages from well-wishers worried about the strange concepts that I have been posting. I sincerely appreciate their good-willed worries about my posted concepts and ideas.

My main interests are "What is life, humans, humanity".

I follow life-sciences internet-published research reports and post comments on them, and I post my conceptions of life-sciences matters and of their implications to us.

The major subjects which I have thus developed as components of my world-view are:

- Definition of Earth-life and organisms.

- Redefinition of Darwinian evlution and its driving force.

- Equivalence of life’s evolution and “Broken Symmetry”, and the implications of "living matter is essentially neither an exception in, nor different from, all other matter".

My posted concepts are ALL founded on cited scientific data. However, they are based on my own interpretations of, and my conclusions from, the cited data.

B. One specific worry is why I term life's evolution "Darwinian"

I refer to life's evolution as "Darwinian" out of respect-gratitude to the active presenter and promoter of the concept of Earth-life's evolution.

My "re-definition" of the evolution of biologic matter and of its drive, together with the evolution of inanimate matter and its drive, stems and evolves from Darwin's cornerstone. Hence for me evoluton of biologic matter, within evolution of ALL matter, is "Darwinian".

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Circadian Rhythm-Metabolism Link Is Self-Explanatory

I.

"Circadian rhythm-metabolism link discovered"
http://esciencenews.com/articles/2008/07/24/circadian.rhythm.metabolism.link.discovered

The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process.

II.

Circadian-rhythm is the genes' innate rest time,

which - together with life's chirality - are the earliest evidences of Darwinian life evolution, the evolution of the primal, 1st stratum, Earth organisms, the genes.

From "SC displaced more easily when off-duty"
"It is unclear why the stem cells leave their niche during a patient's time of rest"
[Dov Henis comment posted in TS, 2008-10-10]
http://www.the-scientist.com/blog/display/55081/

SC are more easily displaced during the organism's rest time simply because their genes and genome is off-duty then, part of the duty is to be on-call at the specific site where it is:

"Life's Chirality And Circadian Rhythm,
Evidence Of Updated Darwinian Evolution"

A. Updated life's concepts:

http://www.the-scientist.com/community/posts/list/20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd
stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis.

- Life's evolution is not random. It is biased, driven by culture.

B. Earliest evidences of updated Darwinian evolution:

- Life's chirality
http://www.the-scientist.com/community/posts/list/122.page#387
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

- Circadian rhythm
http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299

III.

Circadian Rhythm-Metabolism Link Is Self-Explanatory, and new "findings" are not required for suggesting that proper sleep and diet could help maintain or rebuild organism's "equilibrium" and for explaining why lack of proper rest, or disruption in our normal sleep patterns, is known to cause several unhealthy things in us and accelerate our aging process.

Suggesting,

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

For 2008 Sciencenews Of The Year YOK The World-Wide Economy Collapse
Money Printing Will NOT Cure The Technology Culture Greed Cancer

A. "2008: Science news of the year"
http://www.sciencenews.org/view/feature/id/39395/title/2008_Science_news_of_the_year

Science News editors and writers survey the top news from the world of science in 2008. The selected stories are featured in this year-end issue, with 13 subjects'-links to the original stories.

B. The subject of one of the 13 hotlinks to the full stories is "science and society",

and - unbelievable - the 2008 world-wide economy collapse YOK, it does not even exist there...no mention and no reflection or pondering on its nature, symptoms and cause.

C. The world-wide economy can be saved ONLY by conceptual and factual renovation of the personal, social and societal values of the 1920s technology culture

Science and technology must be conceptually and administratively divorced from each other in order to renovate our culture, including economy.

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

Since the 1920s technology development has been THE TOOL of capital formation and accumulation, together with their inherent social and societal values, attitudes and life style and even together with their inherent individual and societal-social ethics.

D. The Technology Culture Greed is neither a lofty nor an essential societal cultural ideal that must be maintained and upheld at all costs,

even if presently, at end 2008 and start 2009, we see a continuous pitiful obstinate inertial clinging of the greed-devotees to stock-markets activities all over the world. They just would'nt accept reality...

E. Money printing will NOT cure the technology culture greed disease

Money printing in this state of affairs, like a blood transfusion in a terminal situation, will only enable temporary precarious respite, not cure. It would take a steadfast dedicated campaign of cultural inovation to save ourselves from collapse and proceed on a route of rational science culture.

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Evolution is biased at genes replication routes, at their alternative-splicing-steps junctions

A. A reply to one of my posts:

"Dov, you write: Life's evolution is not random. It is biased, driven by culture.

Be sure you understand that Darwin did not say that evolution is random. He said that evolution is not random. It is driven by natural selection."

B. I never wrote anything that Darwin said. Here, again, is what I say and wrote:

Culture is the universal driver of genetic evolution

The major course of natural selection is not via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased genes replication routes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third stratum multicells organism or monocells community to their second and prime strata genome-genes organisms."

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

It's The Culture, Not The Biologic Clock
The Clock Is Innate Since Life's Day One
It's Culture That Drives Genetic Changes
And Culture Evolves Per Intelligence

A. From "Hot clock key to fruit fly’s global spread"
http://www.sciencenews.org/index/generic/activity/view/id/39546/title/Hot_clock_key_to_fruit_fly%E2%80%99s_global_spread

"Widely distributed fruit fly species have a temperature-sensitive step in the manufacture of a key part in their biological clocks."

"The gear, a protein known as PERIOD, helps set the circadian clock in fruit flies and many other animals".

B. The above abstract displays a deficit of some comprehensions

of the nature of the CLOCK and of the functional nature of the PROTEIN and of the PROTEIN'S ORIGIN.

The CLOCK is innate in genes-genomes, as genes are primal organisms and genomes are multiGenes organisms and as at genesis the ONLY source of activity energy for genes was the daylight's sun radiation. This is why sleep is a ubiquitous inherent organism's trait.

The functional nature of the protein is, as normal in biologic systems, a cue-tag to specific member(s) of the genome, the cooperative multiGenes communal organism, directing what-when to express, in this case "rest untill the temperature decreases to X degrees, then work".

This specific protein tag was produced by a specific gene at a biased alternative-splicing-step junction, effected by the cultural feedback of the fly, like in all normal evolutionary cases
in which a third stratum multicells organism or monocells community furnish cultural feedback to their second and prime strata genome-genes organisms as genetic evolution biasing instructions.

And the extent of the capability of the genes-genome to respond to the feedback and to effect the thus requested "mutation"-modification, the extent of this capability is the genome's INTELLIGENCE, its capability to assess survival experience and to react-respond to it.

C. Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1