http://www.the-scientist.com/community/posts/list/9.page JForum - http://www.jforum.net

From

http://www.sciencenews.org/view/generic/id/33948/title/Cancer_and_college

"Highly educated people have reaped the benefits of cancer prevention and treatment. Death rates in this group have fallen, but people with less education have missed out on these gains."

Seems to me like hypocritical pseudoscientific misconception.

I suspect it's definitely and obviously and commonsensely not cancer and college but cancer and money. It simply happens that college is also and money...

Dov Henis
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From "Loud and clear"

http://www.sciencenews.org/view/generic/id/33933/title/Loud_and_clear

"Skulls of Neandertal ancestors show the prehistoric humans had a hearing capacity similar to present-day people, suggesting human speech could have originated much earlier than previously thought."

Indeed human speech may have originated earlier than some researchers contend; however and since speech, as well as every and of all biological functions, do not come about due to "capacity". The biological "capacity" evolves consequent to the survival-cultural-requirement drive of the organism.

A small difference...

Dov Henis
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[b]I.[/b] The two faces of prion proteins

http://www.sciencenews.org/view/generic/id/34119/title/The_two_faces_of_prion_proteins

- "Scientists are learning more about the protein behind mad cow and Creutzfeldt-Jakob disease, including how to interfere with the proteins' production in the brains of mice. "

- "It’s also a mystery how prions replicate — they seem to do it without DNA — and they are difficult to kill."


[b]II.[/b] At Genesis replicating RNA-related oligomers replicated without DNA!

IMO there is a definite, even if yet vaguely understood, relationship between CJ and Life Genesis phenomena parallel to the likewise relationship between black-holes and biosphere phenomena.

Black-holes and Biosphere(s?) are both phenomena of constrained energy pockets within a universe of expanding energy.

CJ and Life Genesis are both phenomena of serendipitous occurrence of favourable energy potential, in the case of life genesis between incoming sun's radiation and RNA-related oligomers, and in CJ proteins replication between specific protein-forming-enzymes and enzymes-protein complexes:


[b]III. [/b]Prions, Normal and Pathogenic.

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=125

(A) Aug 15, 2004 DH, biologicalEvolution forum.

Re Scientific American July 2004, "Detecting Mad Cow Disease", SB Prusiner.

Genesis and replication modes of pathogenic prions curiously connote initial genesis and evolution of life, maybe from an RNA-related conformation. In both cases the process-enabling-moving circumstances are presence of the precursors of the Bingo Conformation plus a favorable energy balance.

Is it probable/possible, therefore, that the switch from normal to pathogenic prions is enabled and moved by a replacement of a component amino-acid such as tryptophane/niacin ?

(B) Aug 28, 2004 DH, biologicalEvolution forum.

The subject intrigues me because back in the early '50s I effected encephalomyelitis in fowls by inadequate levels of niacin or tryptophane and found that the minimal required level of these amino acids for the type of fowl was related to the physiology/weight/activity characteristics of the different fowl types.

My gut feeling (obviously not experimental evidence) is that PrPc to PrPSc conversion is indeed a "posttranslational conversion", initiated and maintained by a replacement of an amino acid, initiated and chain-reacting due to an energetically effected equation situation, on one side the PrPc precursors and on the other side the precipitating PrPSc.

Now I just read (The Scientist) updated reports that purified PrPSc do not replicate and that indeed various PrPSc's differ in amino acid component(s) .

Therefore it is required now to learn if tagged PrPc shows up in the PrPSc, or not, for finding if the PrPSc is formed from PrPc, or if it is formed instead of and to the exclusion of PrPc.

Also these data enhance the probability that the pathogenic PrPSc's include an adjunct "agent", lost upon PrPSc purification, that directs the preferred formation of PrPSc. end.

Dov Henis

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[b]It Did Not Evolve Via Pre-Existing Pathways[/b], As You Suggest.

(posted earlier at physforum.co)


[b]A. [/b] http://www.sciencedaily.com/releases/2008/03/080311215702.htm

Quote:
Based on the data, we think that the brain has a pre-existing substrate, namely a forebrain motor pathway, that led to the evolution of similar vocal learning pathways in three different bird families," Jarvis said.

The connection between movement and vocal learning also extends to humans, Jarvis suggests. Human brain structures for speech also lie adjacent to, and even within, areas that control movement. "We can make a plausible argument that in humans, our spoken language areas also evolved out of pre-existing motor pathways," he said. These pathways, he believes, date back to the common ancestor of reptiles, birds and mammals, creatures called stem amniotes that lived about 300 million years ago."
end quote.


[b]B.[/b] Is the view of Science dimmed by pre-Copernicus/Galileo cataract?
Or are 21st century scientists orthodox religious people?

"We can make a plausible argument that in humans, our spoken language areas also evolved out of pre-existing motor pathways," he said. """!

At some time "pre" there was not "existing", and sometime somehow the "existing" must have come into being...

When will 21st century Science realize that IT IS CULTURE THAT DRIVES EVOLUTION and not evolution that drives culture, that it is the daily experiences (culture) of life forms - the 2nd stratum genomes and 3rd stratum monocell communities and multi-celled organisms - that imprint the modifications ("mutations") in the primal stratum life organisms, the genes!

Dov Henis
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When will 21st century Science realize that IT IS CULTURE THAT DRIVES EVOLUTION and not evolution that drives culture, that it is the daily experiences (culture) of life forms - the 2nd stratum genomes and 3rd stratum monocell communities and multi-celled organisms - that imprint the modifications ("mutations") in the primal stratum life organisms, the genes!

Dov Henis


[i]For Better Attention :[/i]

[b]IT IS CULTURE THAT DRIVES EVOLUTION[/b] and not evolution that drives culture.

It is the daily experiences (culture) of life forms - of the 2nd stratum genomes and of the 3rd stratum monocell communities and multi-celled organisms - that imprint the modifications ("mutations") in the primal stratum life organisms, the genes!

Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1[/quote]]]> http://www.the-scientist.com/community/posts/preList/122/356.page http://www.the-scientist.com/community/posts/preList/122/356.page GMT

Of course. Both are doing best to survive.

This rational and very interesting approach is presented at

http://www.nsf.gov/news/news_summ.jsp?cntn_id=111275&org=NSF&from=news

The report includes also this interesting info:

Nowhere is the principle of "strength in numbers" more apparent than in the collective power of microbes: despite their simplicity, these one-cell organisms, that number about 5 million trillion trillion strong (no, that is not a typo) (5x10^30 by the American system. Dov) on Earth, affect virtually every ecological process, from the decay of organic material to the production of oxygen... and viruses are known to be ten times more abundant than even microbes...

Fwd by Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/363.page http://www.the-scientist.com/community/posts/preList/122/363.page GMT
(posted also in physforum.com)


[b]Because genes are organisms and age too...[/b]


[b]A.[/b] Yeast, worms and people may age by similar mechanisms...

http://www.eurekalert.org/pub_releases/2008-03/cshl-got030608.php

"Nearly all organisms experience aging".


[b]B. [/b]And the organisms genes do not "experience aging"?

Right you are. "Nearly all organisms experience aging".
But why "nearly"?

Not only yeast, worms and people. Also genes and the interdependent-genes-communes, genomes. These are organisms, too. It is their "lifehood" that makes us and all life forms "alive".

By plain common sense, my favorite scientific approach, they should also be "experiencing aging"...


[b]C.[/b] The aging of genes should be contributing to aging of organisms...

Since genomes are cooperative communes of interdependent genes there are many genes that "modulate aging" to smaller or larger extent at various time-rates depending on circumstances and environment and.... various things happen to them or affect them and impair their functionalities and ....

Suggesting,

Dov Henis
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(posted also in physorg forum)


Some remarks re some of the statements in the abstract report "Insights From Genes Unique To Humans", at

http://www.eurekalert.org/pub_releases/2008-03/wuso-fsh032108.php

Each and every properly conducted research project adds information and data to the store of our knowledge, regardless of the rational of the plan of the research or of the conclusions attributed to its results; this work not excepted:


1) "Evolution, Stahl notes, naturally tends to retain genes involved in the most important components of metabolism".

Evolution does not "tend do do" anything. Evolution doe not have an active ubiquituous existence anywhere and is NOT A LAW OF NATURE. Evolution is plainly and simply one of a variety of systemized observations-accounts of processes and events. In genetics, evolution - modifications - of genes, the primal life stratum, is driven by the culture of the genome, the second stratum organisms, and by the culture of the third stratum organisms which are the monocellular communities and the multi-celled organisms.


2) Are "humans-only genes" and "hominoids genes" interchangeable terms?

I wonder...


3) "...interesting for evolutionary biologists to try to develop a sense for where these humans-only genes come from," Stahl says. "The building blocks of these genes may be present but not active in earlier species."

I.e. somehow, sometime back, those "building blocks", those just-right-dedicated Lego pieces, were installed and fixed to be dormant until at a later sometime, somehow their collection became active, to assume specific function(s)...to become active genes...

Again, science must be rescued from the middle-ages conceptions...

suggesting,

Dov Henis

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http://www.sciencenews.org/view/generic/id/34186/title/Brains_for_a_change

"Outsized brains may have sped up evolution of body size in birds" ?

NO, NO, NO.

What YES?

YES More variety in body size goes with bigger brain!

Evolution of body size variety in birds has been bringing about bigger sized brain!

[i]A small difference...[/i]

Again and again and again :

It is not physiological evolution that drives culture, which is modes of life and phenotypic varieties.

It is culture that drives physiological evolution. Variety of modes of life brings about also bigger size brain...the individuals face new challenges...


Dov Henis
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(posted also in physorg)


[b]A.[/b] From "Bistable Cell Division Switch":

http://www.eurekalert.org/pub_releases/2008-03/dumc-ast032108.php

This switch is part of a critical pathway that controls cell division, production of new cells. Before a cell starts to divide, it goes through a checklist to make sure everything is in order. If the checklist uncovers something wrong, it can halt the process. But once a cell passes a "restriction point", there’s no turning back, no matter the consequences. The switch controls this milestone and is key to cell growth.

The switch is part of the Rb-E2F signaling pathway. Rb, or retinoblastoma, is a key tumor suppressor GENE, and E2F is a protein, a GENE TRANSCRIPTION FACTOR that governs the expression of all the genes essential for cells to grow. This wiring diagram is fundamentally the same in different organisms, to regulate their growth.

The cellular pathway that includes the switch is found in all multi-cellular life, from plants to people. A decision within the cell triggers the pathway when an external chemical signal to grow is received.


[b]B.[/b] Who decides to do cell division or, generally, to do any thing, within the OCM, the outer cell membrane?

Let's leave aside the many decision-related questions such as when and how a need for a decision is prompted, how decisions are instructed and executed. Let's apply ourselves now ONLY to the question WHO makes the decision.

I conjecture that the genome behaves not as being presided by a decider PG, a President Gene, but by innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.


Conjecturing,

Dov Henis

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(Nov 11, 2005 DH,biologicalEvolution forum)

Music is a human cultural-artifactual elaboration of creatures' vocal communication which is an extension-elaboration of >24 wks-old in-womb fetus' and of newborns' intimate safe/coddle/sooth experiences. Both 'touch' and 'hear' senses are founded on mechanical sensing processes involving in-cell ions leakage forming electrical action potentials interpreted neurologically.

I suggest/conjecture that the same neurological constellation may be handling both 'touch' and 'hear' senses, being of commom mechanisms and differing essentially only in switch-on modes, and that this evolves in all vocal creatures in conjunction with in-womb safety, followed with baby codling/handling and vocal soothing/communicating, and later also with intimate emotional implications. Hence music has 'engulfing-touching-emotional' connotation and personal music orientation has also childhood-ethnic rootings.

Dov Henis
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(posted also in physorg)

[b]Science Must Refresh Concept Of Evolution[/b]


[b]A.[/b] Unique Human Brain Language Feature Sheds Light On Human Language Evolution

http://www.physorg.com/news125500956.html

"DTI now makes it possible to understand how evolution changed the wiring of the human brain to enable us to think, act and speak like humans."

[b]B. [/b]Come On, Science Technicians, Rethink, Refresh Concepts!

It is NOT that the Uniquely Human Brain Wiring ENABLED US to think, act and speak like humans.

It is that our innitiation and application of thinking and speaking lead to the expansion and modification, by our genome, of the uniquely human brain wiring, that enabled further development of these survival capabilities!

This difference in comprehension is not a minor difference. It is a major prime difference in the conception and understanding of what evolution is and how we fit in it!

Dov Henis

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http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

Chirality In Life Still Awaits Elucidation?

[b]A.[/b] From "...key to life before its origin on Earth?"

http://www.physorg.com/news123440279.html#tab

When scientists synthesize these molecules in the laboratory, half of a sample turns out to be “left-handed” and the other half “right-handed.” But the amino acids that are the building blocks of terrestrial proteins are all “left-handed,” while the sugars of DNA and RNA are “right-handed.” The mystery as to why this is the case, “parallels in many of its queries those that surround the origin of life...”

Thanks to the pristine nature of this meteorite, we were able to demonstrate that other extraterrestrial amino acids carry the left-handed excesses in meteorites and, above all, that these excesses appear to signify that their precursor molecules, the aldehydes, also carried such excesses,” Pizzarello said. “In other words, [i]a molecular trait that defines life seems to have broader distribution as well as a long cosmic lineage[/i].”

[b]B.[/b] From "Allosteric, chiral-selective drug binding to DNA"

http://www.pnas.org/cgi/reprint/97/22/12032.pdf

(Allosteric: of, relating to, undergoing, or being a change in the shape and activity of a protein, as an enzyme, that results from combination with another substance at a point other than the chemically active site)

DNA is polymorphic and exists in a variety of distinct conformations. Duplex DNA can adopt a variety of sequence-dependent secondary structures that range from the canonical right-handed B form through the left-handed Z conformation. Multistranded triplex and tetraplex structures are now known to exist. All of these unique conformations may play important functional roles in gene expression.

[b]C.[/b] Chirality in life still awaits elucidation?

Firstly, reasearch findings should be stated scientifically correctly. In A above NOT "a molecular trait that defines life seems to have broader distribution as well as a long cosmic lineage”, but YES "[i]a molecular conformation dominant in Earth life may have broader distribution and additional cosmic presence[/i].”

Next, re in A above "the mystery as to why this is the case", my conjecture about the probable reasons for the prevailing chirality:

Darwinian evolution started at life's day one, with the genesis of the first organisms, the replicating oligomers, pre-archaea genes. It started under yet-unknown energetic conditions, by a serendipitous accident, with oligomeric (RNA?) conformations, in a soup containing all their essential molecular progenitors. These conformations happened to absorb the amounts of energy enabling their polymerization, to lengths precipitated as determined by the nature and conditions of the soup.

The sugars and the nitrogen-based compounds that, together with the phosphates, are the components of the genes-organisms, are chiral. There probably is an energetic advantage in homochirality and chiral homogeneity for the self-replication of biopolymers.

This serendipitous accident set up a matrix-field of energy with a potential extended between its source, the sun radiation and the precipitating organisms. This was the genesis of the ongoing formation and maintenance of Earth's biosphere.

And since thus the biosphere started it could only evolve in more favorable energetic directions and towards stabler components. Survival. After all this is already the process of life evolution...

This is a scientifically plausible conjecture that elucidates chirality in life...


Dov Henis
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http://www.physforum.com/index.php?showtopic=14988&st=210&#entry336122

[b]A.[/b] Definition of life that "truly captures the essence of what all living things actually are and do"?

http://www.newscientist.com/blog/space/2008/04/life-defined.html

This "new definition of life" seems to me like an engineer's definition of a train:

"Life is a thermodynamically open chemical system with a semi-permeable boundary. It contains an information-based complex system with emergent properties, part of which drives a metabolism based on a proton gradient. The said gradient generates the necessary potential difference across the semi-permeable boundary. The information is heritable and coded in such a way as to allow variation and thus evolution."


[b]B.[/b] "life Is Destined To Become More Complex"?

http://www.bath.ac.uk/news/2008/3/17/ruleevolution.html

Seems to me that Earht's life is NOT "destined to become more complex" but that it evolves to enhance and maintain the energy stored in Earth's biosphere, Plain And Simple, and that like other temporarily constrained energy pockets (f.e. black holes)it will eventually undergo "energetic evolution".


[b]C.[/b] "Viruses arose from the cellular domain...not long after the archaea"

http://www.physorg.com/news124097235.html

"The new analysis also indicates that viruses emerged not long after the archaea, with the superkingdoms eukarya and bacteria following much later – and in that order. This finding may influence the ongoing debate over whether viruses existed prior to, or after, the emergence of living cells, Caetano-Anolles said."


[b]D.[/b] Repeating ad absurdum plain common-sense science comprehensions

[b]1.[/b] http://www.physforum.com/index.php?showtopic=14988&st=165&#entry320236

"Base Darwinistic" evolution starts at Life's day one, with pre-Archaea Genes, with the genesis on the still-not-biotic Earth of pre-genomed pre-celled genes.

[b]2. [/b] http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Viruses, Too, Are Bona Fide Organisms. Evolution is in the direction of more effective survivability; this is not always the direction of more complexing for coping with changing environments and competition. In a stable nutritious environment, like in Earth's oceans, coping with vital requirenments, evolution, is in the opposite direction, simplify tooling and means.

It is plain common sense that viruses, even Viroids and Virusoids, nothing more than single strands of DNA or RNA, sometimes only 200-300 nucleotides long, are organisms as alive as we are, evolved at life genesis era and selected for survival in forms, composition and capabilities by living, and even replicating, off their richer kin. Smart little buggers.

[b]3.[/b] http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=409

Factors Involved In Extended Historical Darwinism:

- Earth Life Is A Real Virtual Affair; it pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere .

- Genes are organisms, originally independent individuals and later interdependent members of genes communes, genomes, all continuously undergoing evolution directed towards survival as long as possible, for maintaining Earth's biosphere at a bio state as long as possible.

- "Culture" (= the totality of ways of the organisms' dealing with its environment: reaction to, manipulation of, exploitation of) is a ubiquitous biological entity, the major effector of genetic evolution, of capabilities and attributes selected for survival.

- The major course of natural selection is not via "random mutations followed by survival", but via interdependent, interactive and interenhencing selection of biased replication routes by genes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third life stratum multicells organism or monocells community to their second and prime strata genome and genes organisms.

- Evolution of life is but a minute component of the evolution of the universe. Cosmic evolution is the evolution of energy. Life, like all objects and processes and natural laws in the universe, are - since none in exsistence at singularity - products of evolution and are continuously further evolving. Everything in the cosmos is fractal, rehappens on many scales, and is continuously evolving. Each and every system in the universe continuously evolves within the total universal evolution and all the systems' evolutions are intertwined and within it life's evolution is the evolution of genes-genomes, in an eventual losing attempt to survive, to maintain - as long as possible - pockets of constrained energy that would otherwise and anyhow eventually expand and dilute with the whole mass and energy of the cosmos...


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Puzzled why even Darwinians do not comprehend that Darwinism starts all the way back with Life's day one, with the pre-archaea not-yet-genomed-celled genes...]]> http://www.the-scientist.com/community/posts/preList/122/388.page http://www.the-scientist.com/community/posts/preList/122/388.page GMT
[b]A.[/b]
[u][b]"Protein links metabolism and circadian rhythms"[/b][/u]

http://www.sciencenews.org/view/generic/id/34438/title/Protein_links_metabolism_and_circadian_rhythms

"Scientists have known for ages that metabolism is tied to the body's daily rhythms. Two new studies suggest how."

"body rhythms are governed by molecular clocks that take about a day to complete a full cycle, hence the name circadian clock. The clocks are composed of proteins whose concentrations or levels of activity rise and fall like the tide."


[b]B.[/b] The "clocks are composed of proteins"...

See "Evolution Of Sleep?"

Re http://www.eurekalert.org/pub_releases/2008-01/uops-swh011108.php

Again and again. The need of organisms for sleep has not "evolved".

It is instilled in the 3rd-stratum organisms, the mono-cell and multi-cell organisms, via the innate characteristics of their 1st-stratum organisms, the genes, members of their genome commune, the 2nd stratum organisms.

Genes are the constitutional prime-base-organisms. Yes, genes are organisms, members of their genome commune, and a "biological clock" is an innate characteristics of genes.

Please look at the brief "Origin Of Circadian Rhythm", at

http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299

or at

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=230


Dov Henis

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[u][b]Gene-environment interaction in yeast gene expression![/b][/u]

http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0060083&ct=1

[i]Unbelievable![/i]

[i]Unexpected![/i]

Culture Is Biology, It Imprints Genetics, Drives Evolution!...

It Is Culture That Drives Evolution!...

Gee! Some scientists are beginning to get a glimpse into life beyond the pre- Copernicus/Gallileo conceptions...


Dov Henis
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[b]A.[/b] Researchers used the gene encoding IgH, immunoglobulin heavy chain locus, generator of diverse kinds of antibodies, to demonstrate the structure of the genome.

http://ucsdnews.ucsd.edu/newsrel/science/04-083DImageAntibody.asp

“The resulting structure shows that the antibodys gene is organized into ‘flower-like’ structures that are connected by linkers. These flowers contain the various parts that ultimately generate the wide variety of antibodies. This is the first time that geometry has been used to determine the structure of a genetic locus. Ultimately, the same approach should be used to elucidate the structure of the entire human genome.”


[b]B.[/b] Relevant terms:

Exon : the polynucleotide sequence that codes information for protein synthesis and that is copied and spliced together with other such sequences to form messenger RNA.

V(D)J : B cells synthesize and secrete antibodies, high-affinity immunoglobulins. Somatic hypermutation is a mechanism for achieving diversification of immune responses in mature B cells. Antibody genes are modified in such cells in germinal centers, in a part of the lymph node where lymphocyte proliferation and maturation takes place and where T-cells are "educated" to recognize target antigens, invaders. The mutations are effected by recombination of the variable (V), diversity (D), and joining (J) segments of the gene, thus altering immunoglobulin expression.

The (1) subnuclear location and (2) chromatin state of the immunoglobulin heavy-chain (IgH) locus have been implicated in the control of V(D)J recombinations.

[b]
C.[/b] Background: Genes that Control the Immune System, Antibody genes, structure of the immunoglobulin heavy chain locus (Igh)

http://en.wikipedia.org/w/index.php?title=IGH%40&oldid=196689267


[b]D.[/b] The genome "stores genetic information"?

The work report refers to "...the genome is the most essential part of the cell for storing and accessing genetic information..."

This to me is like stating "... the team of astronauts is the most essential part of the space station for storing information about the constitution and functionalities of the space station...".

Strange conception of, and reference to an organism, the genome, within its organ the OCM, its outer cellular membrane... the space station is considered the living organism whereas the team of astronauts is considered an information storage installation...


Dov Henis
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[b]A.[/b] From http://www.physorg.com/news127559887.html

"...it’s ironic that humans and other mammals don’t merely tolerate the toxins, but can crave them and even develop dependencies on them."

[b]B.[/b] From http://www.physforum.com/index.php?showtopic=14988&st=195&#entry331389

"Don't apply anthropomorphic thinking-expectations. Apply genomorphic behaviour expectation.

From genomorphic considerations it is 'Survival At ALL circumstances', both with and without insectiside, is best and should be selected. And in the genome cooperative community survival is best when there is cooperation-synergism between individual genes. There is "on test, careful" native genes-cooperation with a single "new, stranger" in the community and more "acceptance", cooperation, when two different strangers are implanted in the community."

[b]C.[/b] Remeber, two interdependent organisms are involved in drug addiction,

[i]one is the plant[/i] that produces the toxin and[i] the other is the addict[/i].

So where is the irony?

In the case of "drug addiction", from the genomorphic considerations of the plant producing the toxin the more toxin seekers-cravers the more enhanced its own survivability.

Whereas in regards to the toxin seekers-cravers, obviously since they do not feed back a rejection-damage to their genome, their base prime organism, why should their genome-genes select an uncalled-for "defense modification-mutation"?.

In view of the present human "culture" our genome is not yet conditioned to select a specific toxin-defense gene capability... it may eventually do so, but it will take, as nature goes, many many more years...


Suggesting,

Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/415.page http://www.the-scientist.com/community/posts/preList/122/415.page GMT

[b]A.[/b] I find this abstract ironically amusing:

http://www.eurekalert.org/pub_releases/2008-04/esf-ctu041008.php

"...unravel how genes are regulated and shed light on how cells become different..."

"...biology’s most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression..."


[b]B.[/b] A good explanation of epigenetics, and dictionary definitions

http://jama.ama-assn.org/cgi/content/full/299/11/1345

[i]epi·gen·e·sis[/i]: 1: development of a plant or animal from an egg or spore through a series of processes in which unorganized cell masses differentiate into organs and organ systems; also : the theory that plant and animal development proceeds in this way —

[i]epi·ge·net·ic[/i]: 1 a: of, relating to, or produced by the chain of developmental processes in epigenesis that lead from genotype to phenotype after the initial action of the genes b: relating to, being, or involving changes in gene function that do not involve changes in DNA sequence


[b]C.[/b] The ET alien team's report

I'm reminded of the story about the report of the first ET alien team who circled Earth and observed the goings-on on its surface. They reported home that the main Earth organisms are various forms of mobile configurations moving on circular organs, containing small in-and-out-going parasites.


[b]D. [/b]Cells are not organisms

The outer cell membranes (OCM) are organs. The compositions, structures, shapes and functional capabilities of these organs are very elaborate, but they are still organs. It is not the cells that are the organisms. The organisms, their "parasites", are the genomes that design and construct the OCMs and utilize them.


[b]E.[/b] The universe and life are fractal

Everything in the universe, including life, is fractal and evolves fractally. Earth life started with not-yet-genomed nor-celled genes. Its earliest edition of genomed-celled construction were the Archaea (archae=ancient, primitive). Had the pre-Archaea genes become "parasites" in their OCM? The OCM became necessary for its designers-inhabitants for surviving changes in their circumstances.

Sometime in the future humanity may have to, fractally, repeat the feat of the archaea...to learn to survive in hostile circumstances in enclosures. Would'nt it be ironically amusing?...

For the rational common-sense progress of human culture humanity would be better off to free itself from old conceptions-traditions and further promote its scientific cognition.

Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
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(Feb 10 2008, in physorg forum)


[b]A.[/b] "Comparing Patterns of Natural Selection across Species Using Selective Signatures"

http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0040023

Author Summary

"Natural selection promotes the survival of the fittest individuals within a species. Over many generations, this may result in the maintenance of ancestral traits (conservation through purifying selection), or the emergence of newly beneficial traits (adaptation through positive selection). At the genetic level, long-term purifying or positive selection can cause genes to evolve more slowly, or more rapidly, providing a way to identify these evolutionary forces. While some genes are subject to consistent purifying or positive selection in most species, other genes show unexpected levels of selection in a particular species or group of species—a pattern we refer to as the “selective signature” of the gene. In this work, we demonstrate that these patterns of natural selection can be mined for information about gene function and species ecology. In the future, this method could be applied to any set of related species with fully sequenced genomes to better understand the genetic basis of ecological divergence."

[b]B.[/b] From "Life, Tomorrow's Comprehension"

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Chapter II

Natural Selection Is A Two Level Interdependent Affair

1) Evolution ensues from genome/genes modifications ("mutations"), inherently ever more of them as new functional options arise for the organism.

2) Modifications of genome's functional capabilities can be explained by the 3rd-stratum, cellular organisms' culture-life-experience feedbacks, via its genome, its 2nd-stratum organism, to the relevant gene(s), it's prime-stratum organism. The route-modification selection of a replicating gene, when it is at its alternative-splicing-steps junctions, is biased by the feedback gained by the genome. THIS IS HOW EVOLUTION COMES ABOUT.

3) The challenge now is to figure out the detailed seperate steps involved in introducing and impressing the 3rd-stratum organism's experiences (culture) feedbacks on its founding parents' genome's genes, followed by the detailed seperate steps involved in biasing-directing the genes to prefer-select the biased-favored splicing.

4) I find it astonishing that only very few persons, non-professional as well as professional biologists-evolutionists, have the clear conception that selection for survival occurs on two interdependent levels - (a) during the life of the second-stratum progeny organism in its environment, and (b) during the life of its genome, which is also an organism. Most, if not all, persons think - incorrectly - that evolution is about randomly occurring genes-genome modifications ("mutations") followed with selection by survival of the progeny organism in its environment. Whereas actually evolution is the interdependent , interactive and interenhencing selection at both the two above levels.

end chapter II

Dov Henis

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[b]A. [/b]Recent paradigms of old concepts

I find today, Aug 2 2008, looking at eurekalert, at least three glaring examples that demonstrate clearly and glaringly that it's about time that Life Sciences Should Enlighten Old Concepts Of "Stem Cells":

1- "Survival of the fittest: even cancer cells follow the laws of evolution"

http://www.eurekalert.org/pub_releases/2008-08/foas-sot080108.php

Of course, it's the cells' drivers, the genes-genome...

2- "Harvard-Columbia team creates neurons from ALS patient's skin cells"

http://www.eurekalert.org/pub_releases/2008-07/cumc-htc072808.php

Of course, the shape and functionalities of the OCM (outer cell membrane) and genes are dictated by their "cultural", survival requirements-experience, circumstances as determined by their genes-genome drivers...

3- "Stanford fruit-fly study adds weight to theories about another type of adult stem cell"

http://www.eurekalert.org/pub_releases/2008-07/sumc-sfs072808.php

Of course, it's not about "another type of stem cell" but about the elementary conceptions of what life is and what "cells" are...


[b]B.[/b] The OCM, outer cell membrane, is but an organ of the genome, which IS the organism

1- Genes are primal and genomes are evolved multigenes organisms

Earth Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

Earth organism: a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.

Gene: a primal Earth's organism.

Genome: a multigenes organism consisting of a cooperative commune of its member genes.

Cellular organisms: mono- or multi-celled earth organisms.


2- Update of life sciences conceptions is now feasible and urgently desirable

- Earth's biosphere phenomenon is a distant relative of black holes, a form of constrained
energy pocket.

- First were independent individual genes, Earth's primal organisms.

- Genes aggregated cooperatively into genomes, multigenes organisms, with genomes' organs.

- Simultaneously or consequently genomes evolved protective and functional membranes, organs.

- Then followed cellular organisms, with a variety of outer-cell membranes shapes and
functionalities.


[b]C. [/b]It is culture, life experience, that modifies genetics,
not genetics that modifies culture


Genes, Earth's primal organisms even when they are interdependent members of their genome communal cooperative, evolve in response to their survival requirements, which are THEIR CULTURE.

Darwinism started with pre-Archaea individual independent genes, their evolution driven by their culture.

From http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=409

- Genes are organisms, interdependent members of genes communes, genomes, all continuously undergoing evolution directed towards survival as long as possible, for maintaining Earth's biosphere as long as possible, which is the reason and target-purpose of their, and our, existence.

- Culture is a ubiquitous biological entity and is the major effector of genetic evolution, of capabilities and attributes selected for survival.

- The major course of natural selection is NOT via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased replication routes by genes at their alternative-splicing-steps junctions, effected by the cultural feedback of the 3rd stratum celled organisms to their 1st stratum genes organisms via their 2nd stratum genome organisms.

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Puzzled why even Darwinians do not comprehend that Darwinism starts all the way back with Life's day one, with the pre-archaea not-yet-genomed-celled genes...


[b]D.[/b] On natural selection

a- "Comparing Patterns of Natural Selection across Species Using Selective Signatures"

http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0040023

Author Summary

"Natural selection promotes the survival of the fittest individuals within a species. Over many generations, this may result in the maintenance of ancestral traits (conservation through purifying selection), or the emergence of newly beneficial traits (adaptation through positive selection). At the genetic level, long-term purifying or positive selection can cause genes to evolve more slowly, or more rapidly, providing a way to identify these evolutionary forces. While some genes are subject to consistent purifying or positive selection in most species, other genes show unexpected levels of selection in a particular species or group of species—a pattern we refer to as the “selective signature” of the gene. In this work, we demonstrate that these patterns of natural selection can be mined for information about gene function and species ecology. In the future, this method could be applied to any set of related species with fully sequenced genomes to better understand the genetic basis of ecological divergence."

b- From "Life, Tomorrow's Comprehension"

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Chapter II

Natural Selection Is A Two Level Interdependent Affair

1) Evolution ensues from genome/genes modifications ("mutations"), inherently ever more of them as new functional options arise for the organism.

2) Modifications of genome's functional capabilities can be explained by the 3rd-stratum, cellular organisms' culture-life-experience feedbacks, via its genome, its 2nd-stratum organism, to the relevant gene(s), it's prime-stratum organism. The route-modification selection of a replicating gene, when it is at its alternative-splicing-steps junctions, is biased by the feedback gained by the genome. THIS IS HOW EVOLUTION COMES ABOUT.

3) The challenge now is to figure out the detailed seperate steps involved in introducing and impressing the 3rd-stratum organism's experiences (culture) feedbacks on its founding parents' genome's genes, followed by the detailed seperate steps involved in biasing-directing the genes to prefer-select the biased-favored splicing.

4) I find it astonishing that only very few persons, non-professional as well as professional biologists-evolutionists, have the clear conception that selection for survival occurs on two interdependent levels - (a) during the life of the 3rd-stratum progeny organism in its environment, and (b) during the life of its genome, which is also an organism, 2nd-stratum. Most, if not all, persons think - incorrectly - that evolution is about randomly occurring primal-stratum genes modifications ("mutations") followed with selection by survival of the progeny 3rd-stratum organism in its environment. Whereas actually evolution is the interdependent , interactive and interenhencing selection at all the above levels.

end chapter II

Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/423.page http://www.the-scientist.com/community/posts/preList/122/423.page GMT [u][b]Evolution In Expanding And In Impanding System,
Relevance To Life[/b][/u]

[b]A.[/b] At high pressures, inner electrons begin to affect the structure of lithium

http://www.sciencenews.org/view/generic/id/34815/title/Chem_101_


[b]B.[/b] Systems with increased or decreased degrees of freedom

- Expandable system presents increasing degrees of freedom. In an impanding system the degrees of freedom are decreasing.

- Expandable system presents increasing possibilities of modifications. In an impanding system the possibilities of modification are suppressed under force, the higher the force the higher the suppression and the higher the potential energy straining for release - by evolution or by revolution.

- The obvious example of Strain Release is the Big Bang. It would be wise and prudent to bear in mind that the universe is fractal, and that as it evolves various types* of strained sub-systems or situations arise within it, the strain of which is released in various extents of evolution or revolution.


Dov Henis

* including physical, biological, social, etc.,
]]> http://www.the-scientist.com/community/posts/preList/122/442.page http://www.the-scientist.com/community/posts/preList/122/442.page GMT

[b]A.[/b] [/b]Dopamine imbalance triggers Parkinson's disease and drug addiction, two opposite diseases

http://www.eurekalert.org/pub_releases/2008-08/nu-wdf080808.php

"...explained the phenomenon using the analogy of a car..."


[b]B.[/b] [i]The genome is an organism, not a contrivance[/i]

I suggest, again and again, that effects of cell's environments on its functionality be considered and assessed with comprehension that the OCM, the multifunctional Outer Cell Membrane, is but an evolved organ of the organism that lives and functions within it, the living team, the genome.

The genome is a multigenes organism consisting of a cooperative commune of its interdependent member genes. Each of its members has its own constitutional-functional background history, and its own tolerance-reaction to environments-signals reaching it via the functional membranes around the genome. Decisions are made within the OCM most probably as conjectured in

http://www.the-scientist.com/community/posts/list/122.page#373

Planning and assessment of research work in life sciences, especially in cell level matters, should take this recent comprehension into account...

One day, maybe soon, science will comprehend life and the nature of genes-genome...


Dov Henis

[b]PS:[/b]

[b]2008 Updated Life Comprehension:[/b]

1. Definitions Of Earth Life, Organism, Gene, Genome And Cellular Organisms.

Earth Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

Earth organism: a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.

Gene: Primal Earth's organism.

Genome: a multigenes organism consisting of a cooperative commune of its member genes.

Cellular organisms: mono- or multi-celled earth organisms.

2. Update of life sciences conceptions is now feasible and urgently desirable

- Earth's biosphere phenomenon is a distant relative of black holes, a form of constrained
energy pocket.

- First were independent individual genes, Earth's primal organisms.

- Genes aggregated cooperatively into genomes, multigenes organisms, with genomes' organs.

- Simultaneously or consequently genomes evolved protective and functional membranes, organs.

- Then followed cellular organisms, with a variety of outer-cell membranes shapes and
functionalities.

3. Nature, Origin, Function And Purpose Of Life

Nature of Earth life: a replicating construction temporarily constraining and maintaining energy.

Origin of Earth life: serendipitous energy-induced formation of Earth's primal organisms, individual independent genes.

Nature of Earth's organisms: temporary self-replicable constrained-energy genetic systems that support and maintain Earth's biosphere by maintenance of genes.

Function of Earth life: uphold and maintain as much constrained energy as possible by upholding and maintaining Earth's biosphere.

The purpose of OUR life and its promotion is ours to choose and set. It derives solely from our cognition.


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/456.page http://www.the-scientist.com/community/posts/preList/122/456.page GMT [u][b]Neurons Advised, Decide, And Carry Out Decision[/b][/u]

[b]It's Culture That Drives It All[/b]


[b]A.[/b] Eat less, weigh more, nematode

http://www.sciencenews.org/view/generic/id/34923/title/Eat_less%2C_weigh_more

It's in your brain. "Separate neurons in the nematode brain control eating and fat-building. The discovery may help explain some mysteries of obesity."


[b]B.[/b] Hormones are environment-induced organism's cognitions, its cultural expression

- "Certain peptide hormones tell neurons that control swallowing to speed up or slow down feeding. Fat storage is controlled by neurons that get signals through the neurochemical glutamate."

- “Of course feeding is important to how much energy comes in, but it is up to the nervous system to decide what to do with the nutrients — send it for storage or expend it,” Ashrafi says.


[b]C.[/b] What drives production and broadcast of of hormones

What is this vague mysterious "...nervous system...decide what to do.."?

The "vague mysterious nervous system" is CULTURE.

It's culture that drives the production and broadcast of hormones. The organism's culture is the totality of its recognition of and reaction to and exploitation of the environment. It is the life experiences assessed by the organism. Environmental factors are sensed and forwarded into the cell by functional instruments on the Outer Cell Membrane, then messaged to the genome, then the genome's membership decides on a reaction and delegates instructions to the appropriate member genes, who follow up with their tasks and broadcasts...

One day, maybe soon, science will comprehend life and the nature of genes-genome...


Dov Henis
===============
[b]PS:[/b]

2008 Updated Life Comprehension:

1. Definitions Of Earth Life, Organism, Gene, Genome And Cellular Organisms.
- Earth Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.
- Earth organism: a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.
- Gene: Primal Earth's organism.
- Genome: a multigenes organism consisting of a cooperative commune of its member genes.
- Cellular organisms: mono- or multi-celled earth organisms.

2. Update of life sciences conceptions is now feasible and urgently desirable
- Earth's biosphere phenomenon is a distant relative of black holes, a form of constrained
energy pocket.
- First were independent individual genes, Earth's primal organisms.
- Genes aggregated cooperatively into genomes, multigenes organisms, with genomes' organs.
- Simultaneously or consequently genomes evolved protective and functional membranes, organs.
- Then followed cellular organisms, with a variety of outer-cell membranes shapes and
functionalities.

3. Nature, Origin, Function And Purpose Of Life
- Nature of Earth life: a replicating construction temporarily constraining and maintaining energy.
- Origin of Earth life: serendipitous energy-induced formation of Earth's primal organisms, individual independent genes.
- Nature of Earth's organisms: temporary self-replicable constrained-energy genetic systems that support and maintain Earth's biosphere by maintenance of genes.
- Function of Earth life: uphold and maintain as much constrained energy as possible by upholding and maintaining Earth's biosphere.

The purpose of OUR life and its promotion is ours to choose and set. It derives solely from our cognition.


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/462.page http://www.the-scientist.com/community/posts/preList/122/462.page GMT [u][b]Evidence Of Updated Darwinian Evolution[/b][/u]
(a recompilation)

[b]A.[/b] Updated life's concepts:

http://www.the-scientist.com/community/posts/list/20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd
stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis.

- Life's evolution is not random. It is biased, driven by culture.


[b]B.[/b] Earliest evidences of updated Darwinian evolution:

- Life's chirality

http://www.the-scientist.com/community/posts/list/122.page#387
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

- Circadian rhythm

http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299


Suggesting,

Dov Henis

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It's Culture, Life Experience, That Drives Life's Evolution

Not Outsized Brains, Physiological Product Of Evolution


[b]A.[/b] New, repeated, PR communication

Public release date: 14-Aug-2008, "Big-brained animals evolve faster"

http://www.eurekalert.org/pub_releases/2008-08/uocp-bae081408.php


[b]B.[/b] "Culture, A Ubiquitous Biological Entity"

http://www.the-scientist.com/community/posts/list/98.page

and

"NO, NO, NO."

http://www.physforum.com/index.php?showtopic=14988&st=255&#entry358989



Respectfully,

Dov Henis
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[b]A. [/b]Public release date: 15-Aug-2008, "Cancer signatures uncovered"

http://www.eurekalert.org/pub_releases/2008-08/bc-csu081508.php


[b]B.[/b] Cancer cells are reprogrammed cells

- "Creating" Stem- Or Re-Programmed-Cells"

http://www.the-scientist.com/community/posts/list/151.page#455

and

- "Life Sciences Should Enlighten Old Concepts Of Stem Cells"

http://www.the-scientist.com/community/posts/list/20/122.page#423

Again, Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd stratum organisms, and cellular organisms are evolved 3rd stratum. About time that scientists' guilds, their Establishment, shake off their pre Copernicus inertia and reformulate their thinking and work accordingly...

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/490.page http://www.the-scientist.com/community/posts/preList/122/490.page GMT

[b]A. Culture Is Ubiquitous In Life, It Is A Biological Entity[/b]

From
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

... also suggest that general comprehension of evolutionary biology is an essential pre-requisite for the study of cultural anthropology.

- Culture is a basic biological entity. It is a ubiquitous elaboration-extension of genome's activity beyond its outermost cell membrane, and of multicelled organisms' behaviour. It has been selected for survival of genes-genome as means of extending their exploitation capabilities of the out-of-cell environments-circumstances, consequent to the earlier evolution and selection of the genome's organ, its outermost cell membrane, for controlling the inside-of-cell genes-commune environmental circumstances.

- Every cultural element is an artifact which involves biological intra- and inter-cell expression and/or process; biological and cultural domains are not ontologically distinct, but instead culture inheres in biology.

- In the case of human cultures, ethnocentrisms are phenotypic cases of anthropocentrism; biologically both are normal Darwinian biological survival phenomena. Thus ethnocultures are human phenotypic survival tools.


[b]B. Inception And Prevalence Of Western Monotheism[/b]
[i]Western Monotheism Is A Progeny Of Science[/i]

From
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=138

[b]I.[/b] From old- to new-testament

I do not view cultural-religious affairs through the eyes-conception of historians or theologians, nor do I regard them as "spiritual" matters. For me culture is a ubiquitous biological matter, selected for survival by modes of response to, and manipulation of, the environment. Thus I view and regard cultural-religious affairs through the eyes of an, amateur,evolutionary biologist.

In my compiled OT book Avraham, the immigrant from Ur Kasdim to Canaan, in need of a territorial god protection in Canaan, his new location, "contracted" with Yehovah a "mutual-obligation" covenent. Circa 400 years later Moses extends Avraham's covenant by "obtaining from Yehovah" a refreshed "alliance" even while still not yet resettled in the original covenant-territory, and basing this alliance on an "history-long mutual god-people committments". After additional circa 800 yrs the Judeans in exile in Baylon modify "Yehovah's territoriality", rendering Yehovah omnipresent.

However, through all the above years and through the following development of Christianity, first as a Jewish sect and later, via synthesis with hellenistic culture, as a separate religion, I do not find any record of concepts of monotheism. The Roman empire accepted Judaism as one of the several tolerated "legal" ancient religions within the empire, as the Roman religious culture recognized and accepted age-respectful polytheism.

From a point-of-view of an amateur biology-evolutionist it is rational and sensible and expected that a cultural-religious phenotype will claim for ITS god all the conceiveable and unconceiveable superlatives, for best survival prospects. I started this thread in a sincere attempt-hope to find if and when absolute explicit monotheism was initiated and how prevalent it is. I developed a vague feeling that monotheism, absurdly, is a product of the scientific period and of scientific mentality.

[b]II. [/b]Monolatry To Monotheism, A Scientific Transformation?

A.

R.Dawkins: "Carl Sagan put it well: ... if by "God" one means the set of physical laws that govern the universe, then clearly there is such a God. This God is emotionally unsatisfying ... it does not make much sense to pray to the law of gravity."

IMO both of them have stopped short of the cosmic lookout post. NO. Nature's patterns, physical laws and rules at all cosmic levels, have NOT always been there. They have been evolving since singularity, from nil through ever more complexity, at an ever consequent accelerating rate which is typical of an evolving system, through a metastable cosmos probably towards one of its two stable states, to then reverse its evolution back towards singularity....

Thus this their god is an "evolving god"...

B.

In the 17th-18th centuries Western philosophy underwent a most innovative process, in response to intensive intellectual developments in natural science, religion, and politics, changing concepts and doctrines inherited from ancient and medieval philosophy.

The 17th century scientific revolution involved changes in scientific practices and founding of new scientific societies such as the Royal Society and the Academie Royale des Sciences, and was accompanied with change in how natural philosophers described the knowledge that resulted from the new scientific practices.

I conjecture that it was in this era that "scientific monotheism" was seeded and began to take root, as an expression of the then revealed infinite cosmic incomprehensibility.

C.

Of course, with a transformation from Monolatry To Scientific Monotheism the antonym of atheist is not only simply religious, and a believer is not only one who has a firm religious faith in a certain deity...

Dov Henis

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[b]Eosinophils Mitochondrial DNA defense[/b]

[b]By mtGenes, Primal Organisms Of Early Bacteria[/b]

[b]A.[/b] Immune cell DNA defense

http://www.sciencenews.org/view/generic/id/35045/title/DNA_defense

Scientists find a type of white blood cell releases its mitochondrial DNA, along with toxic proteins, as a defense against invading bacteria.

But ..."the scientists aren’t sure how the cells catapult their DNA with such force... the mechanism may be similar to how some plants expel pollen. The team also speculates that the DNA-protein nets may actively lasso bacteria, or at least provide a physical barrier to the invasion."


[b]B. [/b]Something about mitochondrial mtDNA (wikipedia)

In humans (and probably in metazoans in general), 100-10,000 separate copies of mtDNA are usually present per cell (egg and sperm cells are exceptions). In mammals, each circular mtDNA molecule consists of 15,000-17,000 base pairs, which encode the same 37 genes: 13 for proteins (polypeptides), 22 for transfer RNA (tRNA) and one each for the small and large subunits of ribosomal RNA (rRNA).


[b]C. [/b]Most unclear aspects of mtGenes may crystallize if genes concepts are crystallized

mtGenes, all genes, are archaic individual independent genes, organisms, evolved into interpendent members of genomes communes.

mtGenes, specifically, are Primal Organisms Of Early Bacteria...now they are the crack team alarmed to encounter relatively big invaders, bacteria...

I conjecture that also the tRNA and rRNA, all RNAs, were once individual independent organisms prior to their evolution and replacement by the stabler, better survivors next generation DNA versions...


Suggesting,

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/508.page http://www.the-scientist.com/community/posts/preList/122/508.page GMT
[b]A.[/b] Read the story at:
http://email.newscientist.com/cgi-bin1/DM/y/eBaUz0MjQeZ0mli0FEDK0EK


[b]B.[/b] Reminded of the story about this Sheikh who had a harem with 50 wives. At nightfall he'd ring up the eunuch to bring him wife #1, then sometime later he'd tell him to take #1 and bring #2, then sometime later...etc.,. When the Sheikh died he was 97 yrs old, whereas his first Eunuch died when 57 yr old.

The moral of the story ?!

It's not sexing with women that kills men, but the chasing of them...


Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/509.page http://www.the-scientist.com/community/posts/preList/122/509.page GMT
Wondering what, if any, should be the patenting implications of updated life definitions, with the comprehension that Earth life consists of three organisms strata: genes are primal organisms, genomes are evolved 2nd stratum organisms, and cellular organisms are evolved 3rd stratum.

http://www.actionbioscience.org/genomic/crg.html

http://www.answers.com/topic/gene-patent

Gene patent: The controversial legal practice of patenting a newly discovered gene. It allows unique segments of DNA, which perhaps code for a certain disease or a certain protein, to be owned by an individual or corporation.

Gene: A [i]hereditary unit [/i]consisting of a sequence of DNA that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their DNA sequence changes.

Wondering,

Dov Henis
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[b]A.[/b] "Humans share elements with the lowly beast..."

http://www.eurekalert.org/pub_releases/2008-08/ru-gos082008.php

- "... many large collections of genes...group together on both the Trichoplax and human chromosomes..."

- "What purpose do these large, conserved groupings of genes serve? "Well, that's one of the main questions I'm going after now that I'm setting up my own lab," he said. "Is there a reason they're together? And if they get separated by a mutation, does that disrupt some mechanism of gene regulation, or cause some other problem for an organism?"


[b]B.[/b] To understand "Genes Grouping In Genomes" understand what life is...and understand:

- That Darwinian evolution, as now redefined, started at life's day one on Earth...

- And that Earth life consists of three strata: genes are primal organisms, genomes are evolved second stratum organisms, and cellular organisms are evolved third stratum...


About time that scientists guilds, their Establishment, shake off their pre Copernicus inertia and reformulate their thinking and work accordingly...


Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/528.page http://www.the-scientist.com/community/posts/preList/122/528.page GMT

[b]A.[/b] Nerves Precursors In Marine Sponge.
http://www.eurekalert.org/pub_releases/2008-08/ra-urt082008.php

"What we found in sponges though were the building blocks for nerves, something we never expected to find."


[b]B.[/b] Genes are life's primal organisms even if, in pre-Copernicus concepts, termed 'building blocks'.

Organism's evolution is driven by its culture = its response to its circumstances-environment. Its response is its 'expression'.


About time that scientists guilds, their Establishment, shake off their pre Copernicus inertia and reformulate their thinking and work accordingly...

Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

PS[b]:[/b]

[i]Earth Life:[/i] 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

[i]Earth organism:[/i] a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.

[i]Gene: [/i]a primal Earth's organism. (1st stratum organism)

[i]Genome:[/i] a multigenes organism consisting of a cooperative commune of its member genes.(2nd stratum organism)

[i]Cellular organisms:[/i] mono- or multi-celled earth organisms.(3rd stratum organism)

DH]]> http://www.the-scientist.com/community/posts/preList/122/540.page http://www.the-scientist.com/community/posts/preList/122/540.page GMT

[b]A.[/b] Involvement of misfolded proteins

http://researchnews.osu.edu/archive/targettau.htm

- Alzheimer’s disease is the most common form of dementia among older people. It initially involves the parts of the brain that control thought, memory and language

- In other neurodegenerative diseases, the deposition of aggregates enriched in certain tau isoforms has been reported. When misfolded this otherwise very soluble protein can form extremely insoluble aggregates that contribute to a number of neurodegenerative diseases.


[b]B.[/b] Prions, Normal and Pathogenic.

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=125
and
http://www.the-scientist.com/community/posts/list/122.page#348

- Infectious prions And misfolded proteins. The infectious isoform of normal PrPC, known as PrPSc, is able to convert normal PrPC proteins into the infectious isoform by changing their conformation.

- "Scientists are learning more about the protein behind mad cow and Creutzfeldt-Jakob disease, including how to interfere with the proteins' production in the brains of mice. "

- "It’s also a mystery how prions replicate — they seem to do it without DNA — and they are difficult to kill."

- But, then, it’s also a mystery how at Genesis RNA-related oligomers replicated without DNA!...


[b]C. [/b] Again, a phenomenological relationship...

IMO there is a definite, even if yet vaguely understood, relationship between CJ and Life Genesis phenomena parallel to the phenomenological relationship between black-holes and biosphere phenomena.

Black-holes and Biosphere(s?) are both phenomena of constrained energy pockets within a universe of an expanding energy matrix.

CJ and Life Genesis are both phenomena of serendipitous occurrence of 'favourably-directed' energy potential:

- in the case of life genesis, between incoming sun's radiation and RNA-related oligomeric configuration, and

- in degenerating proteins replication, between specific protein-forming-folding-enzymes and enzymes-protein complexes.


musing,

Dov Henis


]]> http://www.the-scientist.com/community/posts/preList/122/542.page http://www.the-scientist.com/community/posts/preList/122/542.page GMT "It’s also a mystery how prions replicate — they seem to do it without DNA — and they are difficult to kill."
[/quote]

PS: Ease-of-kill is test of lifeness

"It’s also a mystery how prions replicate — they seem to do it without DNA — and they are difficult to kill."

Re the 'uncertainty' about the lifeness of prions or viruses, this is philosophic and factual 'proof' that viruses are alive and prions are not...

DH]]> http://www.the-scientist.com/community/posts/preList/122/549.page http://www.the-scientist.com/community/posts/preList/122/549.page GMT
[i]More samples of old, pre-Copernicus concepts of "Cells"[/i]


[b]I.[/b]

I find today, [b]Sept 2 2008[/b], looking at sciencenews, three fresh samples demonstrating clearly and glaringly that it's about time that Life Sciences Should Enlighten Old Concepts Of "Cells" And Of "Stem Cells":

(1) Stem cells, show your face
http://www.sciencenews.org/view/generic/id/35776/title/Stem_cells%2C_show_your_face
As researchers develop ways of reprogramming adult cells, such as skin cells, to have the same flexibility as embryonic stem cells, this new test shows that the reprogrammed stem cells are truly capable of becoming any cell in the body.

(2) Potent Promise: Essential Stemness
http://www.sciencenews.org/view/feature/id/35962/title/Potent_Promise_Essential_Stemness
Scientists move closer to understanding the dual fates of embryonic stem cells?€‰?€”?€‰to divide or develop

(3) Potent Promise: Back to the Womb
http://www.sciencenews.org/view/feature/id/35978/title/Potent_Promise_Back_to_the_Womb
Reverting adult cells to an embryonic state without creating embryos is a tricky business


[b]II.[/b]

These most recent samples belong with the following earler samples and with the call to Life Sciences To Enlighten Old Concepts Of "Cells"

[b]A.[/b] Recent paradigms of old concepts

I find today, [b]Aug 2 2008[/b], looking at eurekalert, at least three glaring examples that demonstrate clearly and glaringly that it's about time that Life Sciences Should Enlighten Old Concepts Of "Stem Cells":

(1) "Survival of the fittest: even cancer cells follow the laws of evolution"

http://www.eurekalert.org/pub_releases/2008-08/foas-sot080108.php

Of course, it's the cells' drivers, the genes-genome...they're doing best to survive...

(2) "Harvard-Columbia team creates neurons from ALS patient's skin cells"

http://www.eurekalert.org/pub_releases/2008-07/cumc-htc072808.php

Of course, the shape and functionalities of the OCM (outer cell membrane) and genes are dictated by their "cultural", survival requirements-experience, circumstances as determined by their genes-genome drivers...

(3) "Stanford fruit-fly study adds weight to theories about another type of adult stem cell"

http://www.eurekalert.org/pub_releases/2008-07/sumc-sfs072808.php

Of course, it's not about "another type of stem cell" but about the elementary conceptions of what life is and what "cells" are...


[b]B.[/b] The OCM, outer cell membrane, is but an organ of the genome, which IS the organism

1- Genes are primal and genomes are evolved multigenes organisms

Earth Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

Earth organism: a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.

Gene: a primal Earth's organism. (1st life stratum)

Genome: a multigenes organism consisting of a cooperative commune of its member genes. (2nd life stratum)

Cellular organisms: mono- or multi-celled earth organisms. (3rd life stratum)


2- Update of Earth life evolution is now feasible and urgently desirable

- Earth's biosphere phenomenon is a distant relative of black holes, a cosmic form of constrained energy pocket.

- First were independent individual genes, Earth's primal organisms.

- Genes aggregated cooperatively into genomes, multigenes organisms, with genomes' organs.

- Simultaneously or consequently genomes evolved protective and functional membranes, organs.

- Then followed cellular organisms, with evolved variety of outer-cell membranes shapes and
functionalities.


[b]C.[/b] It is culture, life experience, that modifies genetics, not genetics that modifies culture


Genes, Earth's primal organisms even when they are interdependent members of their genome communal cooperative, evolve in response to their survival functionalities, which are THEIR CULTURE.

Darwinism started with pre-Archaea individual independent genes, their evolution driven by their culture.

From http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=409

- Genes are organisms, interdependent members of genes communes, genomes, all continuously undergoing evolution directed towards survival as long as possible, for maintaining Earth's biosphere as long as possible, which is the reason, drive, and target-purpose of their, and our, existence.

- Culture is a ubiquitous biological entity and is the major effector of genetic evolution, of capabilities, functionalities and attributes selected for survival.

- The major course of natural selection is NOT via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased replication routes by genes at their alternative-splicing-steps junctions, effected by the cultural feedback of the 3rd stratum celled organisms to their 1st stratum genes organisms via their 2nd stratum genome organisms.

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Puzzled why even Darwinians do not comprehend that Darwinism starts all the way back with Life's day one, with the pre-archaea not-yet-genomed-celled genes...


[b]D.[/b] On natural selection

a- "Comparing Patterns of Natural Selection across Species Using Selective Signatures"

http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0040023

Author Summary

"Natural selection promotes the survival of the fittest individuals within a species. Over many generations, this may result in the maintenance of ancestral traits (conservation through purifying selection), or the emergence of newly beneficial traits (adaptation through positive selection). At the genetic level, long-term purifying or positive selection can cause genes to evolve more slowly, or more rapidly, providing a way to identify these evolutionary forces. While some genes are subject to consistent purifying or positive selection in most species, other genes show unexpected levels of selection in a particular species or group of species—a pattern we refer to as the “selective signature” of the gene. In this work, we demonstrate that these patterns of natural selection can be mined for information about gene function and species ecology. In the future, this method could be applied to any set of related species with fully sequenced genomes to better understand the genetic basis of ecological divergence."

b- From "Life, Tomorrow's Comprehension"

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Chapter II

Natural Selection Is A Two Level Interdependent Affair

1) Evolution ensues from genome/genes modifications ("mutations"), inherently ever more of them as new functional options arise for the organism.

2) Modifications of genome's functional capabilities can be explained by the 3rd-stratum, cellular organisms' culture-life-experience feedbacks, via its genome, its 2nd-stratum organism, to the relevant gene(s), it's prime-stratum organism. The route-modification selection of a replicating gene, when it is at its alternative-splicing-steps junctions, is biased by the feedback gained by the genome. THIS IS HOW EVOLUTION COMES ABOUT.

3) The challenge now is to figure out the detailed seperate steps involved in introducing and impressing the 3rd-stratum organism's experiences (culture) feedbacks on its founding parents' genome's genes, followed by the detailed seperate steps involved in biasing-directing the genes to prefer-select the biased-favored splicing.

4) I find it astonishing that only very few persons, non-professional as well as professional biologists-evolutionists, have the clear conception that selection for survival occurs on two interdependent levels - (a) during the life of the 3rd-stratum progeny organism in its environment, and (b) during the life of its genome, which is also an organism, 2nd-stratum. Most, if not all, persons think - incorrectly - that evolution is about randomly occurring primal-stratum genes modifications ("mutations") followed with selection by survival of the progeny 3rd-stratum organism in its environment. Whereas actually evolution is the interdependent , interactive and interenhencing selection at all the above levels.

end chapter II

Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/582.page http://www.the-scientist.com/community/posts/preList/122/582.page GMT [u][b]Researchers Uncover DNA Mystery ![/b][/u]


[b]A. Mystery uncovered![/b]

Yale researchers:" 'junk DNA' may have triggered...evolution of..."

http://www.eurekalert.org/pub_releases/2008-09/yu-yrf090208.php

"... evolution may have been driven not only by sequence changes in genes, but by changes in areas of the genome once thought of as "junk DNA"..."


[b]B. Mystery uncovered?[/b]

NO NO NO

DNA does not "trigger" nor drive anything.

DNA is a component of life's prime organism, the gene. The gene, the organism, is "driven" to acquire new capability. The driver is the ubiquitous biological entity, culture.


[b]C. Mystery uncovered. Evolution recomprehended.[/b]

Genes, Earth's primal organisms even when they are interdependent members of their genome communal cooperative, evolve in response to their survival requirements, which are THEIR CULTURE.

Darwinism starts with pre-Archaea individual independent genes, their evolution driven by their culture.

From http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=409

- Genes are organisms, interdependent members of genes communes, genomes, all continuously undergoing evolution directed towards survival as long as possible, for maintaining Earth's biosphere as long as possible, which is the reason and purpose of their, and our, existence.

- Culture is a ubiquitous biological entity and is the major effector of genetic evolution, of capabilities and attributes selected for survival.

- The major course of natural selection is NOT via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased replication routes by genes at their alternative-splicing-steps junctions, effected by the cultural feedback of the 3rd stratum celled organisms to their 1st stratum genes organisms via their 2nd stratum genome organisms.


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=372

Puzzled why even Darwinians do not comprehend that Darwinism starts all the way back with Life's day one, with the pre-archaea not-yet-genomed-celled genes...



]]> http://www.the-scientist.com/community/posts/preList/122/634.page http://www.the-scientist.com/community/posts/preList/122/634.page GMT
[b]A. From "Finding health in fragility"[/b]

http://www.sciencenews.org/view/generic/id/35783/title/Finding_health_in_fragility

"A unifying principle for protein networks' weaknesses could aid development of new drugs"

Westerhoff adds that looking at fragility within a network, rather than just considering individual proteins, could be fruitful for finding new drug targets for a number of hard-to-treat conditions such as obesity, arthritis and even aging. “Humanity’s been able to find treatments for a lot of other, simpler diseases,” he says. “These harder diseases remain unsolved because they aren’t caused by individual proteins. They’re diseases of the network".


[b]B. What are "diseases of the network"[/b]

How Decisions Are Made Within The OCM (outer cell membrane)

http://www.physforum.com/index.php?showtopic=14988&st=180&#entry325606
or
http://www.the-scientist.com/community/posts/list/122.page#373

The proteins, the many "individual proteins", are tools, tools produced by the primal 1st stratum organism, the gene, per directive of the 2nd stratum organism, the genome, consequent to a thorough crisscross checklisting of decision by the members of the genome. The need for a decision is prompted by a signal reaching the genome from within its 3rd stratum organisms, the cells, the network.

In "simpler diseases" there are either fewer proteins involved and their effect on the "network", on the 3rd stratum organisms, the cells, is "direct" and/or there is no involvement of cells-multiplication.

In "harder diseases" there are involved many more proteins and/or also cells multiplications.


[b]C. About time [/b]

About time that scientists guilds, their Establishment, shake off their pre Copernicus inertia and reformulate thinking and work accordingly...

Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/635.page http://www.the-scientist.com/community/posts/preList/122/635.page GMT [b]Steer Spaceships Beyond Our Galaxy?[/b]


Embarassing self-undermining own scientific respect:

[b]A. [/b] From http://www.aftau.org/site/News2?page=NewsArticle&id=7653

"...to steer spaceships to stars beyond our own galaxy..."


From http://blogs.earthsky.org/dsfportree/

- T. J. Cox and Avi Loeb of the Harvard-Smithsonian Center for Astrophysics have calculated what will happen to our Sun when Andromeda and the Milky Way collide. They found that the Sun will move outward until it orbits about 100,000 light-years from the heart of the new elliptical galaxy. We orbit about 30,000 light-years from the center of the Milky Way today.


[b]B.[/b] Self-undermining own scientific respect

- Don't we “see” today without the use of eyes...? Of course we do... who can count the ways...?

- Humans will despatch spaceships beyond our galaxy...?


With respectful embarassment,

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/686.page http://www.the-scientist.com/community/posts/preList/122/686.page GMT
[b]A. On bioethical questions, from "Ethics, shmethics"[/b]

http://www.the-scientist.com/community/posts/list/197.page;jsessionid=603383B62106A5823C0D931AFC2BE364

"Given the convergence of scientific investigations, it is not logical to... (treat) separate(ly) ...(subjects')...associated ethical inquiries."


[b]B. On Culture, from "Culture, A Ubiquitous Biological Entity"[/b]

http://www.the-scientist.com/community/posts/list/98.page

"In human cultures ethnocentrisms are phenotypic cases of anthropocentrism; biologically both are normal Darwinian biological survival phenomena. Ethnocultures are human phenotypic survival tools"


[b]C. Shmetics for some Ethnics is Ethics for others[/b]

This statement does not need any elaboration...


[b]D. When might ethnics co-live peacefully with universal ethics?[/b]

Co-living is hell for just two different non-compatible ethnocultures as long as both regard their cultural tradition "holy".

Co-living of many different ethnocultures is possible and compatible when all accept, with scientific rational understanding, concurrent adherence of members to some of their ex-religious customs-traditions [i]stripped of their sacred-belief elements[/i].


[b]H. When things are boiled down they end up in the bottom line that IT IS ALL A MATTER OF EVOLUTIONARY BIOLOGY...[/b]


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
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[b]The Tail Wagging The Dog[/b]


For most humans the study of heredity, of variation of organisms, of structure and activity of genes and genomes, is the study of elements and components of the cellular organisms including humans.

This is plainly ludicrous.

The plain fact is that the study of cellular organisms, including humans, is the study of genomes and genes, genes being the primal Earth organisms, now living interdependently in genomes.

All Earth organisms, including humans, are components in and instruments of the evolutionary biology of Earth's genes.


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/713.page http://www.the-scientist.com/community/posts/preList/122/713.page GMT
DH]]> http://www.the-scientist.com/community/posts/preList/122/720.page http://www.the-scientist.com/community/posts/preList/122/720.page GMT [b]A Stick In The Wheels Spokes Of The Human Evolution Carriage[/b]


Indiscriminate affability in societal intercultural relationship is a fashionable striving to avert intercultural conflict by expressing either "understanding empathy" in regards to pheno- or ethno-cultures incompatible with the common societal welfare, or by playing down and blurring the differences between the incompatible cultures.

This indiscriminate affability buys a temporary respite in a stirring societal pond. However, it pays a high price for the temporary apparent gain. The price is a stick in the wheels spokes of the human evolution carriage.

The human evolution carriage rolls from junction to junction towards its destination of survival and maximum feasible benefit for Earth's humanity. It will not advance towards its destination by taking simultaneously routes, each of which leading to another destination. It's either the common survival or the specific pheno- or ethno-survival.

Humanity's optimal life quality may be realized only via an all-Earth science-based rational approach to individual and group life. The purpose of our life and its promotion is ours to formulate and set. It derives solely from our cognition.


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1


]]> http://www.the-scientist.com/community/posts/preList/122/725.page http://www.the-scientist.com/community/posts/preList/122/725.page GMT [b]Fragmented axons in neurons mains release different alarm cue then in periphery cables?[/b]


[b]A. "Immune cell plays good cop, bad cop"[/b]

http://www.sciencenews.org/view/generic/id/36506/title/Immune_cell_plays_good_cop%2C_bad_cop

"Immune cells called macrophages aid neuron regeneration in some parts of the nervous system, but hinder regeneration in the brain and spinal cord."

"If the neuron is wounded in the portion located in the brain or spinal cord (known as the central nervous system) macrophages can prevent regeneration, a new study in the Sept. 17 Journal of Neuroscience shows. But if the injury occurs in other parts of the body (the peripheral nervous system) macrophages help heal the hurt, a second study in the same issue of the journal demonstrates."


[b]B. "Eosinophils Mitochondrial DNA defense By mtGenes, Primal Organisms Of Early Bacteria"[/b]

http://www.physforum.com/index.php?showtopic=14988&st=270&#entry367252

http://www.sciencenews.org/index/generic/activity/view/id/35045/title/DNA_defense

"Scientists had previously reported that the white blood cells known as neutrophils expel their DNA in an effort to trap bacteria. But this was thought to be nuclear DNA, and for the neutrophils it was a suicide mission. These one-use-only cells died for the larger antibacterial movement. The eosinophils are expelling DNA from their mitochondria, the tiny energy factories that populate most cells in the body, but this loss of DNA doesn’t kill the cell. The discovery suggests that scientists need to take a second look at the neutrophil traps, Simon says."


[b]C. Most unclear aspects of mtGenes may crystallize if genes concepts are crystallized.[/b]

mtGenes, all genes, were once archaic individual independent genes, organisms, evolved into interdependent members of genomes communes.

mtGenes, specifically, are Primal Organisms Of Early Bacteria...now they are the crack team alarmed to encounter relatively big invaders, including bacteria ...


Maybe even the tRNA and rRNA, all RNAs, were once individual independent genes, organisms, prior to being replaced by stabler, better survivor next generation DNA versions...and thus relegated to become genes' main functional toolings...


Musing,

Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/746.page http://www.the-scientist.com/community/posts/preList/122/746.page GMT
[b]A. Lobbying the 2008 presidential candidates[/b]

In the news: A new petition developed to lobby the presidential candidates argues that increased federal investments in BASIC energy research are essential.

Obviously increased federal investments in BASIC energy research are essential in order to support, maintain and further promote our science-and-technology culture.


[b]B. From "Science And Technology Evolution Since The 1920s, And Its Societal-Social Implications"[/b]

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

- The nature of the evolution of science and technology since the 1920s has been the most significant molding factor of the present characteristics of our society, and it is vitally important for charting the future course of our society to learn and understand this evolution.

- Why is it that since the 1920s technology has been evolving dynamically whereas basic, non-applied, science has been progressing - in my opinion - at ever decreasing rate?

- Basic, non-applied science, since the 18th century Enlightenment the banner of social and societal evolution out of entrenched traditional doctrines and values, has been abandoned and presently barely survives in few institutions. Enlightenment's inherent philosophy and attitudes in regards to individualism, universal human progress and the applications of reason have been pushed off the western culture highway by the ever rising flood of values, attitudes and texture of life of the technology era.

- Are we sure that the present Technology Culture is the culture we want to reign supreme from now on forever?

- We are what we decide to be, and for electing what to be some of us want to know the nature of our essentiality and our place and function in the universe; science will never be sufficient for this but our continuous endless quest, science, is an inherent human characteristic...


[b]C. Biological cognition of Energy, Religion and God[/b]

Humans comprehend now that life is one of the products of evolution of energy-transformation-storage systems, since at Genesis was the energy singularity, eventually there will be near zero mass and an infinite dispersion of the beginning energy, and in-between, the universe undergoes continuous evolution consisting of myriad energy-to-energy and energy-to-mass-to-energy transformations, life being one of them.

Energy is the essence-matrix of the cosmos and of life. Energy is Everything, including biology, "religion" and "god". Yet, we do not comprehend what energy is generically, even if we learned many of its aspects and learned to exploit them.

BASIC energy research is indeed essential...


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1




]]> http://www.the-scientist.com/community/posts/preList/122/772.page http://www.the-scientist.com/community/posts/preList/122/772.page GMT
http://www.sciencenews.org/view/generic/id/36539/title/Pain_relief_to_believe_in

"Religious believers shown pictures that evoke spiritual responses display brain activity that may contribute to feeling relief from physical pain, a new study finds."


[i]"Pictures Evoke Spiritual Responses", in sciencenews?[/i]

What branch of science deals with "Spiritual matters"?

"Spiritual" is biological. Each and every thought or emotion is biological.

"Spiritual" exists as a "realm" seperate from "Reality" in the conceptions and expressions of two groups: (a) religious persons, and (b) those whose welfare depends on wide public support hence on public-appeal public-relation mumbo-jumbo...


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/782.page http://www.the-scientist.com/community/posts/preList/122/782.page GMT

[b]A. The brain on age[/b]
http://www.sciencenews.org/view/generic/id/36708/title/This_is_the_brain_on_age

- "The activity of genes in men's brains begins to change sooner than it does in women's brains, a new study shows."

- "The types of genes that change with age also differ between the sexes."


[b]B. Human male and female are phenotypes [/b]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=143

May 5, 2005 Dov Henis, biologicalEvolution forum

(a) From Scientific American, May 2005, p.22, "His Brain, Her Brain", By L. Cahill :

* "It turns out that male and female brains differ quite a bit in architecture and activity."

* "Neuroscientists are uncovering anatomical, chemical and functional differences between the brains of men and women".

* "Several intriguing behavioral studies add to the evidence that some sex differences in the brain arise before a baby draws its first breath".

(b) Two of the many definitions of "phenotype":

* "The detectable expression of the interaction of genotype and environment constituting the visible characters of an organism".

* "The observable characteristics, appearance or constitutional, of an organism due to the interaction between the genotype and the environment."

(c) I am not well informed in the matters of the subject article but plain common sense, without need to resort to verbiage, suggests that a comparison of organism's male's and female's genomes reveals, or would most likely reveal, a set of expressions of genes of different patterns, evolved in the course of different physiological adaptive demands/preferences of male and female.


[b]C. From "Culture, A Ubiquitous Biological Entity"[/b]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=262

Culture is the universal driver of genetic evolution.

The major course of natural selection is not via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased genes replication routes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third stratum multicells organism or monocells community to their second stratum genomes and finally to their prime stratum genes, organisms.

There is a basic, sex-related difference, between women's and men's cultures, between woman's and man's genes,in addition to the therefore inherent physiological differences between their brains.


Dov Henis

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[b]A. Safer creation of stem cells, maybe, hopefully [/b]

http://www.sciencenews.org/view/generic/id/36881/title/Safer_creation_of_stem_cells_

A new technique for converting adult cells to stem cells avoids dangerous mutations in cell DNA.

The goal is that the cells, termed "induced pluripotent stem cells" (iPS), can eventually be made safe for transplantation in humans.

Currently retroviruses are used, carrying four separate genes that effectively wipe the developmental slate of an adult cell. The Retroviridae used now are single-stranded RNA viruses that produce reverse transcriptase, using their RNA as a template they produce corresponding DNA and incorporate it into the genome of infected cells. These foreign DNA are often tumorigenic, including the lentiviruses (as the HIVs) and the causative agent of Rous sarcoma.

In the new development adenoviruses are used. These are DNA viruses, Adenoviridae, that don't normally integrate into the genome of cells that they infect and therefore present smaller risk of cancer.

The safer virus carries the same four genes ( Oct4, Sox2, Klf4 and c-Myc ) into adult cells but instead of inserting them into the cells’ genetic code, the virus lets the genes free-float within the cells. Proteins encoded by these genes "do the actual reprogramming", and the cells’ protein-making machinery can read the four genes even if they’re adrift in the cells. Eventually, the cells degrade the genes, and the viruses get lost as the cells repeatedly divide.

Stadtfeld says the team doesn’t know yet why the skin cells needed extra help, or why the conversion rates were so low. These two problems must be solved before reprogrammed cells could be used for medical treatments.


[b]B. For Me This Is A Proof Of My Concept That Genes Are Organisms[/b]

Read the abstract again, with a concept that DNA genes are organisms and RNA genes are pre-DNA archaic yet active organisms and many proteins are cues for pre-programmed genes' activities.

It is necessary to overcome a reflective resistance to conceive certain polymers as living, organisms. However, the plain simple fact of life is that genes are organisms, the primal organisms of Earth, the LIFE of Earth. All other organisms evolve and live temporarily to promote and maintain the genes, to promote and maintain the temporary store of energy which is Earth's biosphere.


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1 ]]> http://www.the-scientist.com/community/posts/preList/122/799.page http://www.the-scientist.com/community/posts/preList/122/799.page GMT
You may find this post of interest:

[b]The Essence of Science-Informed Humanistic Western Culture [/b]

http://www.the-scientist.com/community/posts/list/148.page#828

DH
]]> http://www.the-scientist.com/community/posts/preList/122/829.page http://www.the-scientist.com/community/posts/preList/122/829.page GMT

[b]1) What, grosso modo, is "Western Culture"[/b]

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=262

"Western culture" is the ongoing dynamically evolving science-informed culture, initiated in Western Europe, tinted with a variety of regional/national/ethnic/religious aspects. Its essential characteristic is a continuous flexible adaptation to ever evolving science-informed findings-comprehensions, with various degrees and modes of concurrent dismissal or modification of traditional supernatural cultural phenotypic aspects". ([i]my definition.DH[/i])


[b]2) But since the 1920s "western culture" has an additional major feature[/b];
"Societal Implications Of Science And Technology Evolution Since The 1920s"

http://www.the-scientist.com/community/posts/list/61.page#215

Since the 1920s technology development has been THE TOOL of capital formation and accumulation together with their inherent social and societal values, attitudes and life style and even together with their inherent individual and societal-social ethics.

Basic, non-applied science, since the 18th century Enlightenment the banner of social and societal evolution out of entrenched traditional doctrines and values, has been abandoned and presently barely survives in few institutions. Enlightenment's inherent philosophy and attitudes in regards to individualism, universal human progress and the applications of reason have been pushed off the western culture highway by the ever rising flood of values, attitudes and texture of life of the technology era.

The values, attitudes and texture of life of the technology era include a "freely competitive capitalistic market", free of government regulation. This has been both good and bad. The good has been the wide public-based "capital formation and accumulation" that enabled extensive economic growth. The bad has been the regulation-free manipulation of this capital to accumulate gain far in excess of the market value of the production by this accumulated capital. This excess non-productive speculative investment kept inflating until exploded, until realization that it has been plundered, not utilized in production of sellable products. It has been realized now that this bad aspect of the hitherto technology culture must be modified, must become regulated with rational political control, to overcome the societal damages that might be inflicted by the natural human element, greed.


[b]3) "Biological Evolution Of The Concepts Energy, Religion and God"[/b]

http://www.the-scientist.com/community/posts/list/40/122.page#772
http://www.physforum.com/index.php?showtopic=14988&st=300&#entry376941

Humans comprehend now that life is one of the products of evolution of energy-transformation-storage systems...

...that the universe undergoes continuous evolution consisting of myriad energy-to-energy and energy-to-mass-to-energy transformations, life being one of them...

...that energy is the essence-matrix of the cosmos and of life... that energy is everything, including all biologies and hence all of cultures...



[b]4) "Basic Study Of Life Ceased In The 21st Century"[/b]

http://www.the-scientist.com/community/posts/list/54.page#412

In "biological evolution" the subject is "evolution", the evolution of biological processes.
In "evolutionary biology" the subject is "biology", the biology of evolution processes.

- Basic, non-applied science, since the 18th century Enlightenment the banner of social and societal evolution out of entrenched traditional doctrines and values, has been abandoned and presently barely survives in few institutions. Enlightenment's inherent philosophy and attitudes in regards to individualism, universal human progress and the applications of reason have been pushed off the western culture highway by the ever rising flood of values, attitudes and texture of life of the technology era.

- Are we sure that the present Technology Culture is the culture we want to reign supreme from now on forever?

- We are what we decide to be, and for electing what to be some of us want to know the nature of our essentiality and our place and function in the universe; science may never be sufficient for this, but our continuous endless quest, science, is an inherent human characteristic...


[b]5) Western Culture Is Wavering At 2008 Junction [/b]

We are facing now a period of several years of painful exposures and treatments of more and more malignant pnenomena of economic-cultural aspects of our societal organisation.

We need a fresh authoritative scientific organization, freed from the hitherto politically correct webs of "spititual realms" and "technologically-applicable-only" cultures.

An Enlightenment course of societal evolution matrixed on rational scientific grounds may become probable and possible if a fresh authoritative scientific organization is established "by and for the people including scientists", in which scientists operate and make editorial decisions on scientific rather than on political grounds.

It is obvious that our culture must undergo a radical change, in nationally considered and planned direction and manner, with national and global security and welfare considerations. Are we up to it?


Dov Henis ]]> http://www.the-scientist.com/community/posts/preList/122/844.page http://www.the-scientist.com/community/posts/preList/122/844.page GMT

Stem Cells Emerge At Night
http://www.the-scientist.com/blog/display/55081/

"it is unclear why the stem cells leave their niche during a patient's time of rest"

SC are more easily displaced during the organism's rest time simply because their genome is off-duty then, part of its duty is to be on-call at the specific site where it is:


[b]Life's Chirality And Circadian Rhythm,
Evidence Of Updated Darwinian Evolution[/b]


[b]A. Updated life's concepts:[/b]

http://www.the-scientist.com/community/posts/list/20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd
stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis.

- Life's evolution is not random. It is biased, driven by culture.


[b]B. Earliest evidences of updated Darwinian evolution:[/b]

- Life's chirality
http://www.the-scientist.com/community/posts/list/122.page#387
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

- Circadian rhythm

http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299


Suggesting,

Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/847.page http://www.the-scientist.com/community/posts/preList/122/847.page GMT
[b]Impact Of 2008 Global Economy Collapse On Future X And Y[/b]

Unbelievable how many essays and postings in all media wonder what might be the impact of the present economy collapse on the future of X and on the future of Y etc.,

Imagine the Titanic seen threatened by closing-in glaciers, multiply thousands-fold its size and passengers number, and imagine many of them wondering about the impact of the upcoming calamity on the meals menues in the dining rooms or on the availability of various facilities in the physical fitness room or on the despatch of mail on board etc.,

Unbelievable.

Human Inertial Behavior...

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/857.page http://www.the-scientist.com/community/posts/preList/122/857.page GMT

[b]A. Can genetic information be controlled by light?[/b]

http://www.uni-kiel.de/aktuell/pm/2008/2008-092-photoresistenz-e.shtml

"DNA, the molecule that acts as the carrier of genetic information in all forms of life, is highly resistant against alteration by ultraviolet light, but understanding the mechanism for its photostability presents some puzzling problems."

"Researchers at Kiel University have succeeded in showing that DNA strands differ in their light sensitivity depending on their base sequences."


[b]B. The DNA polymer molecule itself IS THE PRIMAL LIFE FORM [/b]

The DNA polymer molecule DOES NOT "ACT" "as carrier of genetic information". IT IS LIFE. It is the first stratum of all Earth life. It has evolved from genes into genomes, which then evolved into cellular forms. A gene is an organism, a genome is an organism, and each and all life forms - all organisms - exist and function to maintain and enhance the genes, in order to maintain and enhance Earh's biosphere, which is the drive and purpose of Earth life.

Earth Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.


[b]C. "DNA strands differ in their light sensitivity depending on their base sequences"[/b]

Of course. "DNA strands" are sections, members, of organisms, of genes, that became living organisms as a result of light energy absorption by RNA-related oligomers.

Life Genesis, formation of first genes, was a phenomenon of serendipitous occurrence, in a supportive environment, of 'favourably-directed' energy potential between in-coming sun's radiation and polymerizing RNA-related oligomeric configuration.

Of course the "light sensitivity" of "DNA strands" depend on the constitution of the "strands".


[b]D. So What Else Is New?[/b]

What else can be new when technicians-scientists, depending in all respects on their establishment-guilds, repeat ad absurdum their guilds' mantras, and plan and do "research" in accordance with pre-Copernicus concepts...


Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

]]> http://www.the-scientist.com/community/posts/preList/122/861.page http://www.the-scientist.com/community/posts/preList/122/861.page GMT Life's Evolution Started, Not Absurdly, Even Prior To Genesis
Talk About A Forces-Matter Unified Theory...[/b]

[b]A. "New arthropod species really stuck together"[/b]

http://www.sciencenews.org/view/generic/id/37463/title/New_arthropod_species_really_stuck_together

"Recent fossil discovery shows that new species of arthropod formed chains, raising the possibility of communal behavior."

"This find provides extraordinary insights into the early evolution of group behaviors, possibly representing a combination of reproductive and anti-predatory strategies,” says Martin. “In short, this find should cause all who are interested in fossil behavior to reconsider what we know about group behavior."


[b]B. Earliest Evolution Of Group Behaviors[/b]

Early evolution of group behaviors?
With due respect, more modesty is in order here:

- Earth organism: a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.
- Gene: a primal Earth's organism. (1st stratum organism)
- Genome: a multigenes organism consisting of a cooperative commune of its member genes. (2nd stratum organism)
- Cellular organisms: mono- or multi-celled earth organisms. (3rd stratum organism)


[b]C. Life's evolution started, absurdly ?, even prior to genesis:[/b]

Life Genesis, formation of first genes, was a phenomenon of serendipitous occurrence, in a supportive environment, of 'favourably-directed' energy potential between in-coming sun's radiation and polymerizing RNA-related oligomeric configurations.

Polymerizing RNA-related oligomeric configurations...phasing from chemistry to life...

Life's evolution started, not absurdly, even prior to genesis...


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/875.page http://www.the-scientist.com/community/posts/preList/122/875.page GMT [u][b]"Broken Symmetry" Is Physics' Term Of Biology's "Evolution"[/b][/u]


[b]A. Nobel Prize in physics shared for work that unifies forces of nature[/b]

http://www.sciencenews.org/view/generic/id/37300/title/Nobel_Prize_in_physics_shared_for_work_that_unifies_forces_of_nature

- "Understanding of broken symmetry has been crucial to the standard model of particle physics."

- "The basic laws of physics seem to be incredibly symmetric".

- "The cosmos began as a hot uniform sea of particles in which all the laws of physics had melded into one, but transformed and cooled into a rich tapestry."

- "Nambu discovered a mechanism embedded in the laws of physics that allowed the character of symmetries to 'change as the universe evolved'."


[b]B. My primitive commonsensical understanding of the concept of "broken symmetry" is simply and plainly "evolution".[/b]

My understanding is that:

- "Symmetry" is a "uniformly steady state matrix".

- "Laws of physics" cannot and do not "seem to be" anything. The laws of nature, like rules of grammar for language, are products of cosmic evolution, the evolution of energy. They represent the most often observed repeats of processes. They are not vague mystic directors of the courses of processes, but a summary of their observed repeats.

- "The laws of physics had melded into one" as "the cosmos began as a hot uniform sea of particles"? NO. At singularity there were no "laws of physics".

- "Discovered a mechanism embedded in the laws of physics that allowed the character of symmetries to 'change as the universe evolved'? NO. This is harnessing the horses at the rear of the carriage. As the universe evolved the character of symmetries continuously changed and "laws of physics" have thus evolved.


[b]C. "Broken Symmetry" Is Physics' Term Of Biology's "Evolution"[/b]

[i]This is another Glimpse Of Forces-Matter-Life Unified Theory...[/i]

Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/885.page http://www.the-scientist.com/community/posts/preList/122/885.page GMT [b]Of Physics' "Broken Symmetry" And Biology's "Evolution"[/b]


[b]A. Expounding verbally, not mathematically, on the essence of an eventual unified theory,[/b]

I imagine that it would continuously be approaching further comprehension of universal evolution.


[b]B. Design And Randomness In Cosmic And Life Evolution,
Comprehension Of Evolution[/b]

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=404

http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327257

This is not another attempt to DEFINE evolution.

This is an attempt to COMPREHEND evolution. An attempt to comprehend evolution with, again, my favorite scientific approach, with common sense.

Common sense leads me to start my this attempt with the presently conjectured start-state of the evolution of all evolutions, with singularity, and to then ask what is next. Should we now seek Evolution's Potential? Do we next need a conjectured end-state?

Is evolution a process that arrives at an end-state? How will cosmic expansion end?

We cannot even conjecture...

Will it end with a stable steady state, a balance between the ever self-diluting force that accelerates the motion of galaxies clusters and the since-singularity tensioned space-distance cosmos matrix? Or will it end with a collapse, with a return impansion towards singularity, that will then again ...? And how may it evolve towards its end state?...

Is this unknowability what constitutes the stochastic nature of evolution?

Yet it is observable that every temporary phase of evolution is a start-state of further evolution.

And it is observable that all objects and processes and natural laws in the universe, are - since singularity - products of evolution and are themselves continuously further evolving. Everything in the cosmos is fractal, rehappens on many scales, and is continuously evolving. Each and every system in the universe continuously evolves within the total universal evolution and all the systems' evolutions are intertwined.

And it is also observable that all evolutions are fueled by culture, culture being the totality of ways of the system's dealing (reaction to, manipulation of, exploitation of) with its environment.

Suggesting,
DH

PS: Present state (March 2008) of the stock market appears to point at the relationship between stocks and stochastic... DH


[b]C. Updated PS[/b]

PS: Present state (October 2008) of the stock market appears to point at the relationship between stocks and stochastic... DH


Dov Henis

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/888.page http://www.the-scientist.com/community/posts/preList/122/888.page GMT [b]Because Genes Are Organisms And Age, Too...[/b]


[b]I. "Old age causes problems for gut cells"[/b]

http://www.sciencenews.org/view/generic/id/37382/title/Old_age_causes_problems_for_gut_cells
"Intestinal stem cells go awry in elderly flies."

- "Normally, “adult” stem cells in the intestinal wall churn out a steady stream of new cells to replenish the lining. A push-pull balance between two signaling pathways controls the growth and maturation of these stem cells..."

- "...the malfunctioning of adult stem cells in old age is very similar to what happens in certain human stem cell populations..."

- "...speculated that the decline of the body’s organs in old age is partially due to changes in those organ’s stem cells, but the idea is still relatively new."


[b]II. "Yeast, worms and people may age by similar mechanisms"
"Because genes are organisms and age, too..."[/b]

[b]A. Yeast, worms and people may age by similar mechanisms...[/b]

http://www.eurekalert.org/pub_releases/2008-03/cshl-got030608.php

"Nearly all organisms experience aging".

[b]B. And the organisms genes do not "experience aging"?[/b]

Right you are. "Nearly all organisms experience aging". But why "nearly"?

Not only yeast, worms and people. Also genes and the interdependent-genes-communes, genomes. These are organisms, too. It is their "lifehood" that makes us and all life forms "alive".

By plain common sense, my favorite scientific approach, they should also be "experiencing aging"...

[b]C. The aging of genes should be contributing to aging of organisms...[/b]

Since genomes are cooperative communes of interdependent genes there are many genes that "modulate aging" to smaller or larger extent at various time-rates depending on circumstances and environment and.... various things happen to them or affect them and impair their functionalities and ....

Suggesting,

Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/900.page http://www.the-scientist.com/community/posts/preList/122/900.page GMT
[b]Genes-Genome Are Steadfast Organisms [/b]


[b]A. "New hand, same brain map"[/b]

http://www.sciencenews.org/view/generic/id/37445/title/New_hand%2C_same_brain_map
An investigation of a man who received a successful hand transplant suggests that reorganization of sensory maps in the brain following amputation can be reversed in short order.

"It’s remarkable that an original neural pathway for the hand can be reinstated after years and years,” Kaas says.

"No consensus exists on how the brain rapidly reorganizes sensory maps following hand amputation and then reverses course after surgical attachment of a new hand, comments neurologist Carine Neugroschl of H?pital Erasme in Brussels, Belgium. In a 2005 brain-imaging study of a hand-transplant patient before and after surgery, Neugroschl’s team reported reactivation of the corresponding neural hand map as early as ten days after the operation."

[b]B. "Sensory Maps" consist of connected genes-genomes posts[/b]

The genes-genomes organisms manning these cells posts are innately charged with location-related functional mission programs.

[b]C. Amputation eliminates some programs' primary objects[/b]

Amputation also eliminates secondary objects of genes-genomes organisms manning other cells along the sensory map.

[b]D. Genes-genomes age, like each and all organisms[/b]

Their efficiency at resuming their suspended innate programs with a transplant depends on the scope and extent of their aging history since amputation.


Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/903.page http://www.the-scientist.com/community/posts/preList/122/903.page GMT
[b]First Organism Found In Nature "To Live Independently From Other Species"?[/b]


[b]A. "Community of one"[/b]

http://www.sciencenews.org/view/generic/id/37478/title/Community_of_one

Scientists have discovered how a single bacterial species living in a gold mine in South Africa survives on its own. Its genome contains everything it needs to live independently.

- “This is the first pretty solid evidence that there is another source of energy life can use, and that is radioactive energy,” says Pilcher, who was not part of the team that discovered and analyzed the bacterium. The finding indicates that other rocky planets could support subsurface life that grows on a similar energy source, he says.

- These bacteria likely reproduce very slowly, taking between hundreds to 10,000 years to replicate, the researchers report.


[b]B. It NOW, matured, lives independently from other species,[/b]

- but, evidenced by its genome, it was born and evolved to maturity with other Earth's biosphere's species.

- Very long life cycle due to steady state of environment.

- The cost of a long life in circumstances enabling survival of a community of one is evolution's dead-end, a steady state...

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

[b]PS:[/b] Replace "species" with "human cultural phenotypes" i.e. Western ,Russian ,Chinese, Indian, Muslim, etc., and note interesting parallel features...DH]]> http://www.the-scientist.com/community/posts/preList/122/905.page http://www.the-scientist.com/community/posts/preList/122/905.page GMT

[b]A. "Counting how votes count"[/b]

http://www.sciencenews.org/view/generic/id/37783/title/Counting_how_votes_count

"A rational person will vote, economists show, as an act of altruism."


[b]B. A person will soldier to protect his/her democracy, as act of altruism.[/b]

This I state from memories as WWII veteran, and from later memories in Israel.


[b]C. W H Davies wrote, in Leisure [/b]

http://www.poemhunter.com/william-henry-davies/

"What is this life if, full of care,
We have no time to stand and stare."


[b]D. What is democracy if, full of care, we have no time to be altruistic,[/b]

to be altruistic at least at national elections time...


Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/915.page http://www.the-scientist.com/community/posts/preList/122/915.page GMT
http://www.the-scientist.com/community/posts/list/20/24.page#918


DH]]> http://www.the-scientist.com/community/posts/preList/122/920.page http://www.the-scientist.com/community/posts/preList/122/920.page GMT

[b]A. Our Fishy Origins: "How Tiktaalik got its neck"[/b]

http://www.sciencenews.org/view/generic/id/37677/title/How_Tiktaalik_got_its_neck_
The oldest fossil with a neck, Tiktaalik roseae, shows how animals developed a head for living on land.


[b]B. Our way-back genesis,[/b]

of course, are life's primal genes, phased serendipitously into organisms from RNA-related oligomeric conformations.

It is the genes, life's prime strata organisms, that have been evolving and evolve. The evolution of genomes, the 2nd stratum of life, and of the 3rd life stratum cellular organisms including ourselves, is an interenhancing development of their genes' evolution. Genomes and organisms evolve and exist for maintaining and enhancing the survivability of the genes...

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/929.page http://www.the-scientist.com/community/posts/preList/122/929.page GMT [b]Science Isn't What It Used To Be[/b]


[b]A. From "The News Climate"[/b]

http://www.sciencenews.org/view/generic/id/37637/title/The_News_Climate

- "Whether people choose to peruse news ?€” and where ?€” may explain what role science plays in shaping public opinion on global warming."

- "Science is not the end-all. But it makes a sound beginning for informed public policy. If it can be believed. What will scientists and their public voice — journalists — have to do to restore faith in science?"


[b]B. Science isn't what it used to be[/b]

Until the end of 2nd WW Science used to be regarded by "people" with respect, awe and trust. It was a banner of a route to better and brighter humanity.

But since the mid 20th century science has been ruthlessly overcome by the Technology Culture, with the cowardly cooperation of the organised "scientists" establishment. Instead of being a banner of hope for the "people" it has become a mirror of the "technology-culture brainwashed people".


[b]C. From "Western Culture Wavers At 2008 Junction"[/b]

http://www.physforum.com/index.php?showtopic=14988&st=315&#entry380527

We are facing now a period of several years of painful exposures and treatments of more and more malignant pnenomena of economic-cultural aspects of our societal organisation.

We need a fresh authoritative scientific organization, freed from the hitherto politically correct webs of "spititual realms" and "technologically-applicable-only" cultures.

An Enlightenment course of societal evolution matrixed on rational scientific grounds may become probable and possible if a fresh authoritative scientific organization is established "by and for the people including scientists", in which scientists operate and make editorial decisions on scientific rather than on political grounds.

It is obvious that our culture must undergo a radical change, in nationally considered and planned direction and manner, with national and global security and welfare considerations. Are we up to it?


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/937.page http://www.the-scientist.com/community/posts/preList/122/937.page GMT
[b]Verbiage Of Endless Ambiguity[/b]


[b]A. "Development puts an end to the evolution of endless forms"[/b]

http://www.eurekalert.org/pub_releases/2008-10/plos-dpa102108.php

- "the sparseness of variety in nature can be attributed to the interactions between multiple genes and genetic controls involved in the development of organisms – a much simpler explanation than previously suggested"

- "They concluded that "The theory presented in our paper complements the view of 'development' as a key component in the production of endless forms and highlights the crucial role of 'development' in constraining (as well as generating) biotic diversity."


[b] B. Science Must Be Rescued From Its Guilds[/b]

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=401

Science must be rescued from its guilds, its establishment guilds that accept and promote contributions to ambiguity of science and to intoxication by verbiage.


[b]C. Culture is the driver of genetic evolution [/b]

http://www.the-scientist.com/community/posts/list/98.page

Culture is a basic biological entity. It is the ubiquitous elaboration- extension of the sensing of and reactions to, by the genome, to the goings-on beyond the outermost membrane of its housing organ, the cell, and of multicelled organisms, to the totality of their outer and inner environments.

The major course of natural selection is not via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased genes replication routes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third stratum multicells organism or monocells community to their second and prime strata genome-genes organisms.


[b]D. Culture is the ubiquitous driver of each and all and total universal evolutions[/b]

http://www.the-scientist.com/community/posts/list/40/122.page#888

And it is also observable that all evolutions are fueled by culture, culture being the totality of ways of the system's dealing (reaction to, manipulation of, exploitation of) with its environment.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1


]]> http://www.the-scientist.com/community/posts/preList/122/942.page http://www.the-scientist.com/community/posts/preList/122/942.page GMT
[b]A. "A frustrating view of complexity"[/b]

http://www.sciencenews.org/view/generic/id/38061/title/A_frustrating_view_of_complexity
"The unifying theme of complex systems, a researcher argues, is frustration."

[b]B. All evolutions in the universe are intertwined[/b]

http://www.physforum.com/index.php?showtopic=22994&st=0&#entry381577
"Broken Symmetry" Is Physics' Term Of Biology's "Evolution"

http://www.physforum.com/index.php?showtopic=22994&st=0&#entry381757
"A Glimpse Of Forces-Matter-Life Unified Theory"

"All objects and processes and natural laws in the universe, are - since singularity - products of evolution and are themselves continuously further evolving. Everything in the cosmos is fractal, rehappens on many scales, and is continuously evolving. Each and every system in the universe continuously evolves within the total universal evolution and all the systems' evolutions are intertwined."

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/943.page http://www.the-scientist.com/community/posts/preList/122/943.page GMT
http://www.the-scientist.com/community/posts/list/20/24.page#948


DH]]> http://www.the-scientist.com/community/posts/preList/122/949.page http://www.the-scientist.com/community/posts/preList/122/949.page GMT You're invited to take a look at "On Watson And Racism", at

http://www.the-scientist.com/community/posts/list/20/24.page#952


Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/953.page http://www.the-scientist.com/community/posts/preList/122/953.page GMT
[b]comparative assessment of intelligence of different phenotypes?[/b]


Within a genotype, intelligence is a genetic trait of the individual. It is the capability to assess-adapt. It is the ability to modify cognition-culture in response to variable circumstances-environments.

Culture is a ubiquitous trait, of the inanimate and animate realms, thus intelligence - an element of culture - is a ubiquitous trait.

Approach and method to (comparatively?) (what is it?) assess intelligence of the individuals of cultural phenotypes within a genotype, or to understand and comprehend genotypes' cultures and the intelligence of their individuals, belong in the sphere of the quest for the Forces-Matter-Life Unified Theory.

Cultures are historical cosmic evolutionary entities and the unravelling of the nature of their elements and of their evolution processes is the horizon-goal of the Unified Theory.


Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1 ]]> http://www.the-scientist.com/community/posts/preList/122/957.page http://www.the-scientist.com/community/posts/preList/122/957.page GMT
[b]Why 'Life' In Forces-Matter-Life Unified Theory [/b]


[b]A. From "Science Creed Manifest(SCM)"[/b]

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=142

Humans display a different approach to the scientific study of the nature of life than to the study of anything else. This may be due to an aversion to accept the dismaying realization that we are, after all, just one of the many life forms on Earth (or in our galaxy or the universe?).

A most essential, and uniquely human, ingrained-inherent need is some degree of self-esteem. The mere survival and existence of human individuals and communities of any size is anchored and established on a foundation of self-esteem culture which is neatly a complete creation of humans. Humanity is urgently becoming faced with the vital need to re-formulate its basis of culture, to anchor and build our life edifice on a rational, deeply convincing, moral-ethical-social values.

[b]B. Culture Is A Ubiquitous Trait ("-" from my earlier posts)[/b]

- "Culture is a ubiquitous trait, of both the inanimate and animate realms, thus intelligence - an element of culture - is a ubiquitous trait."

- Within the realm of life not only creatures, but also plants, display culture AND intelligence.

- "Broken Symmetry" Is Physics' Term For Biology's "Evolution"

- "And it is also observable that ALL evolutions are fueled by culture, culture being the totality of ways of the system's dealing (reaction to, manipulation of, exploitation of) with its environment."

[b]C. So Why 'Life' In Forces-Matter-Life Unified Theory?[/b]

Because life is neither an exception in, nor essentially different from, all other matter. All matter consist of energy and serves as a temporary storage of energy, and so is life.

[b]D. Yet within the 'essential' matterness of life[/b]

it is ,of course, observable that life is peculiar in the method and process of reproduction, even though ALL matter undergoes their forms and processes of reproduction, too.


Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1 ]]> http://www.the-scientist.com/community/posts/preList/122/963.page http://www.the-scientist.com/community/posts/preList/122/963.page GMT

Heat sensors guide insects to a hot meal

http://www.sciencenews.org/view/generic/id/37863/title/Heat_sensors_guide_insects_to_a_hot_meal

Bugs home in on seeds by detecting infrared radiation.

It is likely that the Western white Pine cone’s heat is due in part to biophysics — bigger objects collect heat better than smaller objects — and a cone’s surface tends to reflect radiation. But the warmth may also be metabolic, generated during the activity of seed development, says Takacs.

The findings suggest that infrared detection by insects may be much more widespread than previously thought, and might be found in many of the blood-feeding insects, which seek prey that emanate heat, says Takacs.

Generating heat may convey some benefit to the plant, such as aiding in seed development. The insects are taking advantage of that, says Terry. “There are probably trade-offs going on here, as with most biological systems.”


Fwd by Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/973.page http://www.the-scientist.com/community/posts/preList/122/973.page GMT

Please glance at the following four brief essays and then re-read this note.

I humbly suggest that the underlying, essential thought, of these essays deserves your attention:

- Earth's life is an up-phased matter of the inanimate matter, all matter being essentially a format of constrained energy.

- The cosmos is an evolving energy affair consisting of endless intertwined evolutions.

- Culture is a ubiquitous trait of all matter, the driver of Evolution, of all evolutions. This is an extension of Darwin's and Broken Symmetry concepts.

- The further comprehension of Culture and Evolution is the essence of the quest for a Unified Field Theory.

Respectfully yours,

Dov Henis
(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

==========================

(1) On Complexity
http://www.the-scientist.com/community/posts/list/60/122.page#943

(2) "Broken Symmetry" Is Physics' Term Of Biology's "Evolution"
http://www.the-scientist.com/community/posts/list/40/122.page#885

(3) More On Forces-Matter-Life Unified Theory
http://www.the-scientist.com/community/posts/list/60/122.page#957

(4) Why 'Life' In Forces-Matter-Life Unified Theory
http://www.the-scientist.com/community/posts/list/60/122.page#963]]> http://www.the-scientist.com/community/posts/preList/122/982.page http://www.the-scientist.com/community/posts/preList/122/982.page GMT Evolution Of All Matter Is Fueled By Energy.
What About Keynesian Notes In Economy? [/b]

[b]A. At the serendipitous genesis of Earth life[/b]

The serendipitous genesis of Earth life, the up-phase of RNA-conformation oligomers into self-replicating genes - constrained energy polymers - was driven and effected by the sun's radiation. This is evidenced by the Circadian rhythm, an innate genes characteristic, inborn due to the energetic conditions during their genesis, when direct sunlight was their only source of energy, available at different times of day in accordance with their location on Earth...

[b]B. Life monetized energy[/b]

Genesis was a set-up of a matrix-field of energy with a potential extended between its source, the sun radiation, and the precipitated organisms. Thus started the ongoing formation and maintenance of Earth's biosphere.

And since the genes were thus born they could evolve only along more favorable energetic directions, towards ever higher constrained energy capacitance and stabler components. Survival was the direction, and survival is propagation. After all, Life's genesis was the start of Darwin's evolution. An ever more favorable energetic direction have included, most probably, energetic advantage of homochirality. And chiral homogeneity furnished, most probably, stable self-replication of biopolymers.

Thus Life monetized energy since Life's day one.

[b]C. Energy, capacity of acting or being active, fuels culture[/b]

Culture is a basic biological entity. It is the ubiquitous elaboration-extension of the sensing of and reactions, by genes-genome, to the goings-on in and beyond the outermost membrane of their housing, the cell, and of multicelled organisms, to the totality of their outer and inner environments.

These sensings and reactions are enabled by energy, the capacity of acting or being active.

[b]D. Culture drives evolution of all constrained energy items[/b]

By plain common sense it is culture, the ubiqitous biological entity, that imprints genetics and drives evolution of Earth life.

And it is culture, the ubiqitous cosmic entity, that imprints the constitution of all matter in the universe.

[b]E. Life, culture, matter and evolution are fueled by energy[/b]

And energy, the capacity of acting or being active, is REAL. It is not a virtual reality, an artificial image-environment experienced through human sensory stimuli.

[b]F. What about Keynesian notes in economy?[/b]

In the present return to Keynesian steering out of the catastrophic world economy crisis the government is called to stimulate demand through fiscal measures, to effect a balancing act, 'creating' just enough money to cover a 'natural' amount of economic activity, without gliding either towards inflation or unemployment.

This is, in effect, assigning to money and credit in the economy the functional attributes of energy in life's evolution.

However whereas energy, the capacity of acting or being active, is real, money and credit are virtual reality. Their functionality depends on the image-environment experienced through human sensory-imagination stimuli. This smacks of psychology or faith-religion.

So what are the odds that a Keynesian course will steady the rocking boat? The odds are like odds of other things that depend on human reactions-attitudes. This steadying course will be as effective as the conformation of the 'people' with the 'hopeful' reactions-attitudes on which the Keynesian assumption is based...


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1012.page http://www.the-scientist.com/community/posts/preList/122/1012.page GMT

[b]A. From an earlier post:[/b]

In the present return to Keynesian steering out of the catastrophic world economy crisis the government is called to stimulate demand through fiscal measures, to effect a balancing act, 'creating' just enough money to cover a 'natural' amount of economic activity, without gliding either towards inflation or unemployment.

This is, in effect, assigning to money and credit in the economy the functional attributes of energy in life's evolution.

However whereas energy, life's and evolution's monetized currency, the capacity of acting or being active, is real, money and credit are virtual reality. Their functionality depends on the image-environment experienced through human sensory-imagination stimuli. This smacks of psychology or faith-religion.

So what are the odds that a Keynesian course will steady the rocking boat? The odds are like odds of other things that depend on human reactions-attitudes. This steadying course will be as effective as the conformation of the 'people' with the 'hopeful' reactions-attitudes on which the Keynesian assumption is based.

[b]B. Odds of economy's salvation via Keynesian prospects[/b]

- Economy's salvation via Keynesian prospects depends on the "people's" reactions-attitudes to sensory-imagination stimuli effected in them by their societal environment.

- The stimuli thus effected depend, in turn, on the cultural constitution of the "people".

- It is difficult, very difficult, to modify human culture by decree or even by revolution. Human culture changes normally by evolution, a slower, more basic, process than by decree or revolution or even - as exposed in the present world economy - than by reaction to a catastrophe. The evidence of this is all around us nowadays in the world stock markets, and in the lobbyings of inflated-bubbled-businesses for public help lest the "people" are hurt by recession due to the collapse of the bubbles.

The present tone of the world's culture, and even ethics, including the banners of a variety of types and shades of greed, has been set by the 20th century Technology Culture. Its essence is the legitimacy and admiration of gaining capital via virtual activities, activities without or beyond production of real assets, real life resources.

So the odds of the economy's salvation via Keynesian prospects are, in the long run, proportional to the odds that the culture of Earth's humanity will evolve towards ever more rational self-organization...which is, how unsurprisingly rational, the odds of every organism to survive...


Dov Henis
(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1 ]]> http://www.the-scientist.com/community/posts/preList/122/1035.page http://www.the-scientist.com/community/posts/preList/122/1035.page GMT [b]And Reported By Royal Society's Science Coverage[/b]


[b]A. In "Science Coverage"[/b] at

http://royalsociety.org/news.asp?id=8122

"Intelligent humans developed because our female Homo erectus ancestors had wide hips which allowed them to give birth to babies with big brains, according to Indiana University research in Science.
The Daily Telegraph, p18, 1 col
The Independent, p23, 1/2p"

[b]B. Dictionary[/b]

Intelligent = revealing or reflecting good judgment or sound thought.

[b]C. Wonderment[/b]

To what extent this telltale sign held in regards to the mothers of the above Indiana University researchers and Royal Society's science coverers...

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1043.page http://www.the-scientist.com/community/posts/preList/122/1043.page GMT [b]Roots Of Sex And Replication[/b]


[b]A. Women's chromosome division different from men's[/b]

http://www.sciencenews.org/view/generic/id/38528/title/Womens_chromosome_division_different_from_mens
Using fluorescent markers, scientists are discovering that men and women divide chromosomes differently.


[b]B. Replication of organisms, in[/b]

http://www.biology.arizona.edu/Cell_BIO/tutorials/pev/main.html

[b]a.[/b] RNA Viruses: reproduce in host cells, no growth on artificial media, no division by binary fission, no protein synthesis machinery, not sensitive to antibiotics.

[b]b.[/b] Binary fission: the process in which a parent cell splits into two daughter cells of approximately equal size. Simple cell division in single-celled organisms.

[b]c.[/b] Prokaryotes: DNA chromosomal ring, plasmid extrachromosomal ring autonomous replication, the plasmids are self-replicating circular molecules of DNA in many bacterial, archaeal, fungal, algal, and plant species.


[b]C. Sex in prokaryotes, bacteria[/b]

http://www.biology.arizona.edu/Cell_BIO/tutorials/pev/page2.html

In prokaryotes, bacteria, you can have sex, with males possessing a sexual apparatus for transferring 'genetic information' to receptive females. However, since you are both always going 30 mph it is difficult to find each other. Furthermore, if you are male, nature gave you a severe problem. Every time you mate with a female, she turns into a male. In bacteria, "maleness" is an infective venereal disease. Also, at fairly high frequencies, spontaneous mutations cause you to turn into a female.

Some bacteria have sex pili which are responsible for bacteria recognizing one another and the consequent formation of a conjugation tube which allows the transfer of DNA from a "male" cell to a "female" cell. In this way, recombination occurs and the resulting cell will contain a combination of genes from each parent cell. 'Male' and 'female' are donnor and receiver.


[b]D. Sex: process of recombining genes to form new and unique combinations[/b]

- Every organism's replication is an accelerated re-run of its genesis-plus-evolution.

- Male-female divisions and relationships and all sex forms are evolutionary developments of prokaryotes' sex, driven by the need to recombine the genes held in the double-helixed DNA, in order to maintain life on Earth (... within the human body about 3 billion cells die every minute...).

Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1




]]> http://www.the-scientist.com/community/posts/preList/122/1067.page http://www.the-scientist.com/community/posts/preList/122/1067.page GMT

[b]A. "Research sheds light on benefits of multiple mates"[/b]

http://www.eurekalert.org/pub_releases/2008-11/uoe-rsl111908.php

"Females of most species, including many mammals, mate with multiple partners. The driving forces for this practice, known as 'polyandry', have been a mystery for evolutionary biologists for decades."

[b]B. The driving force of polyandry is NOT a mystery[/b]

http://www.the-scientist.com/community/posts/list/60/122.page#1067

- Sex: process of recombining genes to form new and unique combinations.

- Look at sex in prokaryotes, bacteria. It has already a stable DNA genome, stabler than its genes' earlier RNA. Now to form new and unique genes combinations the DNA's double-helix must be opened.

- 'Male' and 'female' are donnor and receiver. As male mates with a female, she turns into a male. In bacteria, "maleness" is an infective venereal disease. I conjecture that there, in the prokaryotes, the female's chromosome division already differs from male's, that therein lies the root of polyandry.

- And therein lies also the root of single-cells-community culture. At fairly high frequencies, mandated by the environmental circumstances of the community, 'spontaneous' mutations cause a cell to turn into a female.

- Farthest back in time genetic decisions were made by independent individual genes. As genes formed multi-genes cooperative genomes, individual genes' decisions are either vetoed or approved by the genome's membership. As cells formed communities and/or multi-celled organisms the solicitation for decisions was fowarded by a process of information feed-back from beyond and/or within the outer-cell-membranes' environments. But this leads us to another subject, i.e. to Culture...

Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1070.page http://www.the-scientist.com/community/posts/preList/122/1070.page GMT

[b]A. "Biomarkers To Predict Chronological And Physiological Age"[/b]
http://www.eurekalert.org/pub_releases/2008-11/bifa-but111208.php

Research purpose: "This technology may provide means of testing anti-aging drugs". "Examining biomarkers over time would provide a scientific baseline for clinical trials of anti-aging medicines, currently impossible to determine given the lengthy lifetime of human beings."


[b]B. I reckon that this refers to physiological, not chronological, anti-aging medicines[/b]

Age =

1. chronological duration of the existence of an organism or object, or

2. the measure of an attribute of an organism or object relative to the chronological age of their "average normal individual".

Commonsensically age is determined by rate of degradation, and aging in multicellular organisms is much more complex that in monocel organisms, as there are so many more components in the total system that undergo deterioration and degradation.

In most multicellular eukaryotes, telomerase, the enzyme that elongates chromosomes, is only active in germ cells.

telomere = either of the repetitive DNA sequences occurring at the termini of each chromosome in linear chromosomes of most eukaryotic organisms and of few prokaryotes. Yes, it has shown up historically way back in some linear-chromosomed prokaryotes.


[b]C. Yeast, worms and people may age by similar mechanisms since genes are organisms and age, too[/b]

"Intestinal Stem Cells Go Awry In Elderly"
http://www.the-scientist.com/community/posts/list/40/122.page#900



Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1077.page http://www.the-scientist.com/community/posts/preList/122/1077.page GMT

[b]A. Two related science research reports [/b]

1. Sequencing the dead to learn its evolution history
http://www.sciencenews.org/view/feature/id/38729/title/Sequencing_the_dead_to_save_the_living
Reviving ancient genomes of long-extinct creatures offers a window into past extinctions.

and

2. No gene is an island
http://www.sciencenews.org/view/feature/id/38750/title/No_gene_is_an_island
Even as biologists catalog the discrete parts of life forms, an emerging picture reveals that life's functions arise from interconnectedness.


[b]B. Genetics research may consider introduction of some order in life's complexity[/b]

1. Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
The nature and drive of life, and genes and genomes are organisms.

2. How Decisions Are Made Within The OCM (outer cell membrane)
http://www.the-scientist.com/community/posts/list/122.page#373

The genome behaves not as being presided by a decider PG, a President Gene, but by innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.

Suggesting respectfully,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/1078.page http://www.the-scientist.com/community/posts/preList/122/1078.page GMT

[b]A. From "The decider"[/b]
http://www.sciencenews.org/view/feature/id/38753/title/The_decider
Informing the debate over the reality of "free will" requires learning something about the lateral habenula...

- The lateral habenula is a neural enclave in the brain. “There’s lots of new research showing that an overactive habenula has behavioral effects,” says neuropharmacologist Martine Mirrione.

- "Perhaps,” write neuroscientists Alireza Soltani and Xiao-Jing Wang, “we are entering a new period of consilience between the science of the brain and the science of the mind.”

- "For free will, the issue is understanding the complex circulation of molecular information that is messaged and manipulated at various stations by neural systems tuned to multiple decision-making considerations. That process is free will, even if it isn’t really free. So deciding whether the will is free turns out to be circular, although perhaps not viciously, like some of those fights in The Matrix."


[b]B. "Free will" and "Culture"[/b]

- A consilience between the science of an organism's brain and the science of its mind sounds like a consilience between the science of the computer's hardware and the science of its software.

- Organisms are neither an exception in, nor essentially different from, all other matter. All matter consist of energy and serves as a temporary storage of energy, and so are organisms.

- http://www.physforum.com/index.php?showtopic=14988&st=195&#entry333405
Teleology governs all nature's systems, both living and nonliving. It is universal. All natural facts and processes exist and evolve towards the telos, the end, the next phase of the endless evolution.

- ALL cosmic evolutions are directed by culture, culture being the totality of ways of the system's dealing (reaction to, manipulation of, exploitation of) with its environment.

- The purpose and route of OUR life and their promotion are OURS to formulate and set. They derive solely from our cognition.

- And within the ordained teleological destination of our temporary existence our culture is the expression of our limited opportunity and capability to exercise some degree of free will.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

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[b]A. From "Mammoth genome approaching completion"[/b]

http://www.sciencenews.org/view/generic/id/38707/title/Mammoth_genome_approaching_completion
Genetic material extracted from the hair of woolly mammoths has revealed new information about the extinct creatures, including how closely related they are to modern elephants.

So far, the estimated overlap between the mammoth genome and that of the African elephant is about 99.4 percent...the two species last had a common ancestor about 7.6 million years ago... the rate of genetic change in elephants and their kin is about half that seen in humans and their kin during the same period...Humans and chimps last shared a common ancestor about 7 million years ago, and the genomes of these two species differ by about 1.24 percent...


[b]B. See the brief "Seed of Human-Chimp Genomes Diversity" at[/b]

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=179

A guaranteed eye-opener for this matter...


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1083.page http://www.the-scientist.com/community/posts/preList/122/1083.page GMT

[b]A. "Sleep makes room for memories"[/b]

http://www.sciencenews.org/view/generic/id/38692/title/Sleep_makes_room_for_memories
Sleep erases old memories to make way for new learning...sleep changes the biochemistry of the brain...


[b]B. Sleep neither erases nor inscribes memories[/b]

Sleep does not change the biochemistry of the brain. Memories are inscribed in the brain, and maintained or erased, in genetic biochemical processes.

Again and again. Genes are organisms, even as now interdependent members of their genome communal cooperative, they were born with the environmental habit and need to sleep.

The need to sleep is innate in genes, as evidenced by the Circadian Rhythm. It was daylight's energy that trans-phased the pre-alive RNA oligomers into individual living polymers, the primal genes, and it was daylight's energy that continued being the ONLY source of energy for the early genes, organisms, in the pre-biotic Earth surface. And this state of affairs persisted along the course of evolution of genes into communal cooperative genomes, with chromosomes enclosed in cells and later also in nuclei. It took many many following years for Earth to start evolving its biosphere and to furnish to its life alternative energy sources, as life evolved the capability to exploit the additional types of energy.

Organisms' "biological clock" is thus an inherited matter, an innate characteristic.


[b]C. Sleep does effect the functionality of genes and of chromosomes[/b]

On pre-biotic Earth the functionality of the primal genes, and chromosomes, was decreased or impaired at daylight's energy switch-offs. This is life's innate phenomenon that carried into multicelled organisms.


[b]D. Genes-genomes are NOT "DNA sequences, materials, genetic blueprints..."[/b]

It is necessary to overcome a reflective resistance to conceive certain polymers as living, as organisms. However, the plain simple fact of life is that genes are organisms, the primal organisms of Earth, the LIFE of Earth. All other organisms evolve and live temporarily to promote and maintain the genes, to promote and maintain the temporary store of energy by Earth's biosphere.

The common sad observation is that the science establishment and its publications refer to, and comprehend, genes-genomes organisms in pre-Copernicus pre-Galileo term "genetic codes"... with stubborn insistence on seeing the naked emperor's new clothes, on seeing genes-genomes not as the organisms they obviously are but as "DNA sequences, genetic materials, genetic blueprints..."


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1



]]> http://www.the-scientist.com/community/posts/preList/122/1106.page http://www.the-scientist.com/community/posts/preList/122/1106.page GMT

[b]A. New research sheds light on fly sleep circuit[/b]

http://www.eurekalert.org/pub_releases/2008-11/bu-nrs112508.php

Brandeis scientists research fly sleep to advance understanding of human sleep and its disorders


[b]B. Sleep And Memories, Blueprints And Organisms[/b]

http://www.the-scientist.com/community/posts/list/80/122.page#1106

The common sad observation is that the science establishment and its publications refer to, and comprehend, genes-genomes organisms in pre-Copernicus pre-Galileo term "genetic codes"... with stubborn insistence on seeing the naked emperor's new clothes, on seeing genes-genomes not as the organisms they obviously are but as "DNA sequences, genetic materials, genetic blueprints..."


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1113.page http://www.the-scientist.com/community/posts/preList/122/1113.page GMT

[b]A. Latest News: A Potentially Universal Mechanism Of Aging[/b]
http://www.eurekalert.org/pub_releases/2008-11/hms-ria111908.php

"Researchers have discovered that DNA damage decreases a cell's ability to regulate which genes are turned on and off in particular settings. This mechanism, which applies both to fungus and to us, might represent a universal culprit for aging. "


[b]B. Universal mechanism of aging has been explained earlier...[/b]

Predicting Chronological And Physiological Age Is Complicated
http://www.the-scientist.com/community/posts/list/60/122.page#1077

Genes Are Organisms And Age, Too...
http://www.the-scientist.com/community/posts/list/40/122.page#900


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/1114.page http://www.the-scientist.com/community/posts/preList/122/1114.page GMT

[b]A. "Mouse model of prion disease mimics diverse symptoms of human disorder"[/b]

http://www.eurekalert.org/pub_releases/2008-11/cp-mmo112008.php

"The research, Cell Press Nov 26 2008,journal Neuron, provides exciting insight into the mechanism of the disease."

"This new model allows in-depth analysis of the disease mechanisms".


[b]B. The mechanism is least-energy protein-folding...[/b]

"Prion Proteins, 2008 "
http://www.the-scientist.com/community/posts/list/122.page#348

"Neurodegenerative Diseases, Prions, And Life Genesis"
http://www.the-scientist.com/community/posts/list/20/122.page#542

"Ease-of-kill is test of lifeness"
http://www.the-scientist.com/community/posts/list/20/122.page#549


Degenerating proteins replications are phenomena of serendipitous occurrences of "favourable-energy-balance" proteins foldings, involving specific protein-forming-folding-enzymes and enzymes-protein complexes.


Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

]]> http://www.the-scientist.com/community/posts/preList/122/1115.page http://www.the-scientist.com/community/posts/preList/122/1115.page GMT

[b]A. Epigenetic heredity, beautiful work and findings[/b]

http://www.eurekalert.org/pub_releases/2008-11/cshl-csd112608.php

Scientists found a new way in which 'epigenetic information' is inherited. A class of small RNAs inherited from the mother determines offspring’s 'fertility trait'.

"It remains to be seen whether this mechanism of epigenetic inheritance is found in organisms other than fruit flies. Small mother's RNAs are probably deposited in oocytes of every animal, Hannon hypothesizes."

In hybrid dysgenesis, transmission of *transposon by a parent induces sterility in the offspring, unless the offspring also inherits a factor that suppresses the transposon and maintains fertility. Since the phenomenon had only been seen when the transposon-transmitting parent was male, the suppressing factor was thought to be maternally transmitted, but it was never identified until now.

Hannon's team has now found that the stockpile of maternally derived proteins, RNA, and nourishing raw material in developing fruit fly oocytes, or egg cells, also includes piRNAs. And these maternally deposited piRNAs prove to be essential for mounting a silencing response against the culprit transposons.

*(A transposon is a mobile segment of DNA that serves as an agent of genetic change. Some transposons move by 'cut and paste' into new locations. Others stay put but 'self- copy and paste' themselves elsewhere in the genome.)


[b]B. About epigenetics[/b]

Epigenetic = relating to gene functional changes that do not involve changes in the DNA sequence.
Example: methylation, methyl groups attached to DNA.

http://www.sciencedaily.com/releases/2008/06/080624174849.htm

The rates of change of the extent of epigenetic marking and activity are genetically phenotypic, varying with age similarly within family members, and "could be an important link between environment, aging and genetic risk for disease".

BTW this age-and-epigenetics work, IMO, enhances my conception of the nature of life
"Life's Manifest"
http://www.the-scientist.com/community/posts/list/112.page#578


[b]C. The piRNAs work is outstanding, yet could be more[/b] if gene-genome realized to be the organisms they are

One day, maybe yet in the 21st century, science will look back with amused disbelief at old terms and concepts like "letters of the DNA sequence" and "epigenetic information", in regards to living and aging, genes-genome organisms..


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

[b]PS:[/b]

Another recent work demonstrates beautifully effect of tinkering with a single gene

Minus one gene, male mouse is Mr. Mom
http://www.sciencenews.org/view/generic/id/38719/title/Minus_one_gene%2C_male_mouse_is_Mr._Mom
The goose becomes the gander, and vice versa.

Male mice...become doting parents and accomplished homemakers when a gene that senses pheromones
is removed from the region of their brain...

Removing the Trpc2 gene from male mice made them act like females, whereas females rendered to lack the Trpc2 gene act like males...

Fwd by DH]]> http://www.the-scientist.com/community/posts/preList/122/1118.page http://www.the-scientist.com/community/posts/preList/122/1118.page GMT

[b]A. "The new face of peer review", [/b]in "Funding Opportunities and Advice" forum, at
http://www.the-scientist.com/community/posts/list/298.page

refers to "changes to the peer review process".


[b]B. However, "peer review process" is the least disturbing aspect of "peer review" in science[/b]

Samples of factual observations of other negative aspects of peer review in science:

- http://www.digibio.com/archive/SomethingRotten.htm
"A U.S. Supreme Court decision and an analysis of the peer review system substantiate complaints about this fundamental aspect of scientific research. Far from filtering out junk science, peer review may be blocking the flow of innovation, and corrupting public support of science."

- "Peer review stifles innovation, perpetuates the status quo, and rewards the prominent. Peer review tends to block work that is either innovative or contrary to the reviewers' perspective."


[b]C. "Peer Review" is, factually, a tool of a "Subversive Activities Control Board"[/b]

The most revolting corrupt aspect of peer review in science is its exploitation by the Science Establishment to tightly clamp its political and financial omni-everything rule and control, including stifling of any shred of scientific innovation.


[b]D. The corruption is not inherent in the tool, but in the nature of the Science Establishment [/b]

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

The peer review process is but a tool of the Establishment. The corruption is not inherent in the tool, but in the nature of the Science Establishment.

As long as Science and Technologhy are considered and handled, conceptually and administratively, as one realm and one faculty this corruption cannot and will not be overcome. This conception and attitude is THE CORRUPTION OF SCIENCE BY THE 21st CENTURY TECHNOLOGY CULTURE.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1121.page http://www.the-scientist.com/community/posts/preList/122/1121.page GMT

[i]Re "God and Evolution Can Co-Exist, Scientist Insists"[/i]
http://www.the-scientist.com/community/posts/list/304.page#1124


- Is there/what is, in the quoted article, a definition of the article's "god" ?

- Specifically, is the article's "god" defined as a human artifact, or not ?

If "god" is defined/understood to be a human artifact - regardless of reasons, purposes, implications, consequences - the subject "god-science" is scientifically discussable.

If "god" is not defined/understood to be a human artifact, its concept is a human virtual reality artifact experienced only through sensory stimuli, and "god-science" is not scientifically discussable. Furthermore, in this case preoccupation with this subject within a scientific frameworks contributes to corrosion and corruption of science and scientism by manifesting or implying acceptance of virtual reality as reality.

[b]"Evolutionary Biology Of Culture And Religion"[/b]
http://www.the-scientist.com/community/posts/list/20/122.page#492


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

[i]Life's Manifest[/i]
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1136.page http://www.the-scientist.com/community/posts/preList/122/1136.page GMT

[b]A. Researchers identify gene in age-related hearing loss[/b]

http://www.eurekalert.org/pub_releases/2008-12/ttgr-hei120108.php

http://hmg.oxfordjournals.org/cgi/content/abstract/ddn402

"Age-Related Hearing Impairment (ARHI), or presbycusis, is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors." "... these data indicate that common alleles of GRM7 contribute to an individual's risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity."

Excitotoxicity = Neuronal injury caused by excessive release of excitatory neurotransmitters, glutamate and aspartate, causing damage to nerve and glial cells, occuring in diverse neurologic diseases that may be acute.

It is the overexpression of glutamate that causes damage to the inner and outer hair cells in the inner ear leading to age-related hearing loss.


[b]B. What is "interaction between environmental and genetic factors"[/b]

"ARHI is a complex disease caused by an interaction between environmental and genetic factors."

In my plain commonsensical mind "interaction between environmental and genetic factors" is a description of organism's "aging". And in my boy's-like view of the emperor's new clothes the aging is of the genes-genome involved, as genes are life's primal organisms and their genome association is life's 2nd stratum organisms, and genes and genomes age as we age, and we age as a result of the aging of our genes and genomes...

[i]Life's Manifest[/i]
http://www.the-scientist.com/community/posts/list/112.page#578


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/1146.page http://www.the-scientist.com/community/posts/preList/122/1146.page GMT [b]Separate Them Conceptually And Administratively[/b]
[b]21st C2ntury Economy Collapse Is Collapse Of Technology Culture[/b]
[b]Enhance Public's Science Information-Awareness[/b]


[b]A. Science Reporting Fallout[/b]
http://www.sciencenews.org/view/generic/id/39060/title/Science_Reporting_Fallout
Newspaper cutbacks are being linked to diminished science reporting.

- Baltimore Sun: " a quick update to yesterday’s story about the epidemic downsizing of U.S. newspaper staffs"...

- Doing ‘more with less’ has degenerated to doing less with less. Science and environment stories are often shortened substantially to meet with tightening space constraints, or they don’t make it into print at all.

- No matter how you spin it, that can’t be good for ensuring an informed electorate. What’s more, you know that with the deep job cuts occurring in newsrooms across the country, the Sun’s approach can hardly be unique...


[b]B. CNN downsizes science team[/b]
http://www.sciencenews.org/view/generic/id/39025/title/CNN_downsizes_science_team
The move and timing for greatly restructuring science-and-environment coverage at the nation's all-news cable giant are perplexing.

According to a prepared statement issued by the network, “We want to integrate environmental, science and technology reporting into the general editorial structure rather than have a stand alone unit. Now that the bulk of our environmental coverage is being offered through the Planet in Peril franchise . . . there is no need for a separate unit.”


[b]C. Since the 1920s technology development has been THE TOOL of capital formation[/b]

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

Since the 1920s technology development has been THE TOOL of capital formation and accumulation, together with their inherent social and societal values, attitudes and life style and even together with their inherent individual and societal-social ethics.

The technology culture has been corrupting the status of science and has relegated science, the banner and hope of human enlightenment and rational evolution, to the file of quaint items. This process has been and is being perpetrated with the dedicated cooperation of the politically entrenched Science Establishment.

As long as Science and Technologhy are considered and handled, conceptually and administratively, as one realm and one faculty this corruption cannot and will not be overcome. This conception and attitude is THE CORRUPTION OF SCIENCE BY THE 21st CENTURY TECHNOLOGY CULTURE.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Science Creed Manifest (SCM)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=142

]]> http://www.the-scientist.com/community/posts/preList/122/1166.page http://www.the-scientist.com/community/posts/preList/122/1166.page GMT [b]Pavlov is smiling[/b]

[b]A. Imagination Medicine[/b]

http://www.sciencenews.org/view/feature/id/39046/title/Imagination_Medicine
Brain imaging reveals the substance of placebos. Expectation alone triggers the same neural circuits and chemicals as real drugs.

"It all boils down to expectation. If you expect pain to diminish, the brain releases natural painkillers. If you expect pain to get worse, the brain shuts off the processes that provide pain relief. Somehow, anticipation trips the same neural wires as actual treatment does.

Scientists are using imaging techniques to probe brains on placebos and watch the placebo effect in real time. Such studies show, for example, that the pleasure chemical dopamine and the brain’s natural painkillers, opioids, work oppositely depending on whether people expect pain to get better or worse. Other research shows that placebos can reduce anxiety."


[b]B. Recommended background info:[/b]

http://www.cerebromente.org.br/n09/mente/pavlov_i.htm
http://www.cerebromente.org.br/n09/mente/placebo1_i.htm
http://thjuland.tripod.com/placebos.html

The concept of a placebo comes from medieval times, when professional mourners were paid to stay by the bedside of. deceased person, reciting a psalm beginning "Placebo Domino..." or "I shall please the Lord." "Placebo" gradually became the word used for the paid mourner, whose grief was, in fact, false.


Fwd'ed by
Dov Henis
]]> http://www.the-scientist.com/community/posts/preList/122/1184.page http://www.the-scientist.com/community/posts/preList/122/1184.page GMT
[b]The GGRPVR Chain:
Genes, God, Religion, Placebo, Virtual Reality.[/b]

[b]A. Imagination Medicine[/b]

http://www.sciencenews.org/view/feature/id/39046/title/Imagination_Medicine
Brain imaging reveals the substance of placebos. Expectation alone triggers the same neural circuits and chemicals as real drugs.

"It all boils down to expectation. If you expect pain to diminish, the brain releases natural painkillers. If you expect pain to get worse, the brain shuts off the processes that provide pain relief. Somehow, anticipation trips the same neural wires as actual treatment does.

Scientists are using imaging techniques to probe brains on placebos and watch the placebo effect in real time. Such studies show, for example, that the pleasure chemical dopamine and the brain’s natural painkillers, opioids, work oppositely depending on whether people expect pain to get better or worse. Other research shows that placebos can reduce anxiety."

[b]B. Placebos: some background info[/b]

http://www.cerebromente.org.br/n09/mente/pavlov_i.htm
http://www.cerebromente.org.br/n09/mente/placebo1_i.htm
http://thjuland.tripod.com/placebos.html

The concept of a placebo comes from medieval times, when professional mourners were paid to stay by the bedside of. deceased person, reciting a psalm beginning "Placebo Domino..." or "I shall please the Lord." "Placebo" gradually became the word used for the paid mourner, whose grief was, in fact, false.

[b]C. Life's Manifest[/b]

http://www.the-scientist.com/community/posts/list/112.page#578

Genes are the primal, first stratum, Earth's organism.

[b]D. Of Science and Religion[/b]

http://www.physforum.com/index.php?showtopic=18243&st=0&#entry267674


[b]E. So why is Pavlov smiling in 2008?[/b]

Pavlov demonstrated effecting placebo phenomena in multicelled organisms by manipulation of their drives-reactions. Now placebo phenomena are demonstrated in the multicelled organism's genes and genomes, in our primal first stratum and 2nd stratum base organisms...a very good reason to smile.

Now an interesting chain is exposed to our view, the GGRPVR Chain, the Genes-God-Religion-Placebo-Virtual Reality chain, a most intriguing cultural evolution chain...


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1


]]> http://www.the-scientist.com/community/posts/preList/122/1185.page http://www.the-scientist.com/community/posts/preList/122/1185.page GMT [b]Living And Inanimate matter[/b]


Re
http://www.the-scientist.com/community/posts/list/20/24.page#1199
[i]What is intelligence? [/i]

[b]A. Over and over again[/b]

"Intelligence, like every "specific" physical property (f.e. specific weight or heat etc.,) is a specific cultural phenotype characteristic. Plain science....

The core (wordnet.princeton) definition of "intelligence" is "the ability to comprehend, to understand and profit from experience". These surviving abilities are different for the different phenotypes within a genotype, therefore each phenotype has its own meaning of "intelligence".

Intelligence is to culture approximately as essential amino acids are to proteins. Culture evolves in response to circumstances by use of intelligence and to the extent and scope feasible by the extent and scope of intelligence."

[b]B. Biological culture is a biological entity[/b].

It is an elaboration-extension of the cell's manipulation beyond its outer membrane. It has been selected for survival of genes and genomes by means of manipulating-adjusting the cell's outer circumstances, in addition to the cell's outer membrane which was selected much earlier for controlling the inner cell's circumstances.

[b]C. But organic and biological, as well as all inanimate matters,[/b]

are all cosmic matters consisting essentially of energy, therefore - strange as it sounds but definitely factual - all and each matter display culture and intelligence, i.e. each displays a unique mode of response to its environment and circumstances (culture) in its unique mode-rate-manner (intelligence).


How much simpler and clearer can culture and intelligence be comprehended and defined?


Respectfully,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/1201.page http://www.the-scientist.com/community/posts/preList/122/1201.page GMT

[b]A. From "Gene could drive species separation"[/b]

http://www.sciencenews.org/view/generic/id/39279/title/Gene_could_drive_species_separation

"A newly identified gene in fruit flies may drive the creation of new species, revealing how internal genetic environments may be just as important as external factors when it comes to speciation. The new work lends evidence to a hotly debated idea in evolutionary biology.


“Conventionally, evolutionary biologists thought that speciation involved adaptation to the external environment, but these results suggest that adaptation to the internal genomic environment also sometimes plays a role,”


[b]B. From "Culture, A Ubiquitous Biological Entity", one of tens of related postings during the last ten years[/b]

http://www.the-scientist.com/community/posts/list/98.page;jsessionid=AE07D240319E7648DDC9073A7AF8BBE3#401

Culture is the universal driver of genetic evolution.

The major course of natural selection is not via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased genes replication routes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third stratum multicells organism or monocells community to their second and prime strata genome-genes organisms.

[b]C. Myopics, Update Your Darwinian Evolution Conceptions![/b]

How many years and how many tens of internet postings will it take until you notice and read and assimilate the Updated Darwinian Evolution Conceptions.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1219.page http://www.the-scientist.com/community/posts/preList/122/1219.page GMT [b]Mumbo Jumbo And Evolution[/b]


[b]A. From "Dolphins wield tools of the sea"[/b]

http://www.sciencenews.org/view/generic/id/39219/title/Dolphins_wield_tools_of_the_sea
A long-term study of dolphins living off Australia's coast finds that a small number of them, mostly females, frequently use sea sponges to forage for fish on the ocean floor.

- "Not everyone regards such food-gathering tactics as purely the products of social learning or culture. Genetic traits and habitat characteristics may influence how animals forage as much as or more than any cultural traditions, argued Kevin Laland and Vincent Janik, biologists at the University of St. Andrews in Scotland, in a 2006 paper."

- "Further research needs to tease out the effects of genes, environments and culture on sponge-assisted foraging by bottlenose dolphins, comments evolutionary geneticist Michael Krotzen of the University of Zurich, who studies the social behavior of bottlenose dolphins and orangutans. “Dolphins are highly intelligent and are prime candidates for social learning in the wild,” he says"


[b]B. Mumbo-jumbo and life's evolution[/b]

Culture (yes, and also intelligence...) is a ubiquitous trait in the inanimate AND animate realms. For life, culture is THE driver of genetic evolution.

A "Tease Out" treatment of a package of genetics, culture, social learning, and environment in regards to behaviour of an organism is a mumbo-jumbo, a pseudoscientific gibberish. Culture is the sum total of behaviour in response to circumstances-environments; the behaviour evolves as enabled by intelligence, and drives and dictates the genetic evolution. Plain and simple.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
]]> http://www.the-scientist.com/community/posts/preList/122/1227.page http://www.the-scientist.com/community/posts/preList/122/1227.page GMT [b]Complexly Instrumented Spacestations Accumulate Damage Over Time[/b]

[b]A. From "Theories about human cellular aging supported by new research"[/b]

http://www.eurekalert.org/pub_releases/2008-12/asfc-bta111908.php

"Research presented at America Society for Cell Biology conference.

Aging yeast cells accumulate damage over time, but they do so by following a pattern laid down earlier in their life by diet as well as the genes that control metabolism and the dynamics of cell structures such as mitochondria, the power plants of cells."


[b]B. Complexly instrumented spacestations accumulate damage over time,[/b]

and their residents, too, age and accumulate damage over time. Yes, the functionality of the stations' residents and of their intruments and equipment is impaired with age. Wonder why?

The reason for the impairment with age of the highly active instrumented-equipped stations and their residents is that they "follow a pattern laid down earlier in their life by diet as well as by the residents who control metabolism and the dynamics of the stations' structures such as mitochondria, their power plants."


[b]C. Enough. Cells are NOT organisms, and genes-genomes are YES organisms.[/b]

Refresh your conceptions and comprehensions and attitudes and research plannings and peer-reviewings. Let your science evolve...


Suggesting,

Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1229.page http://www.the-scientist.com/community/posts/preList/122/1229.page GMT

[b]A. On my strange concepts[/b]

I have recently received messages from well-wishers worried about the strange concepts that I have been posting. I sincerely appreciate their good-willed worries about my posted concepts and ideas.

My main interests are "What is life, humans, humanity".

I follow life-sciences internet-published research reports and post comments on them, and I post my conceptions of life-sciences matters and of their implications to us.

The major subjects which I have thus developed as components of my world-view are:

- Definition of Earth-life and organisms.

- Redefinition of Darwinian evlution and its driving force.

- Equivalence of life’s evolution and “Broken Symmetry”, and the implications of "living matter is essentially neither an exception in, nor different from, all other matter".

My posted concepts are ALL founded on cited scientific data. However, they are based on my own interpretations of, and my conclusions from, the cited data.


[b]B. One specific worry is why I term life's evolution "Darwinian"[/b]

I refer to life's evolution as "Darwinian" out of respect-gratitude to the active presenter and promoter of the concept of Earth-life's evolution.

My "re-definition" of the evolution of biologic matter and of its drive, together with the evolution of inanimate matter and its drive, stems and evolves from Darwin's cornerstone. Hence for me evoluton of biologic matter, within evolution of ALL matter, is "Darwinian".


Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
]]> http://www.the-scientist.com/community/posts/preList/122/1233.page http://www.the-scientist.com/community/posts/preList/122/1233.page GMT

[b]I.[/b]

"Circadian rhythm-metabolism link discovered"
http://esciencenews.com/articles/2008/07/24/circadian.rhythm.metabolism.link.discovered

The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process.


[b]II.[/b]

[b]Circadian-rhythm is the genes' innate rest time[/b],

which - together with life's chirality - are the earliest evidences of Darwinian life evolution, the evolution of the primal, 1st stratum, Earth organisms, the genes.

From [b]"SC displaced more easily when off-duty" [/b]
"It is unclear why the stem cells leave their niche during a patient's time of rest"
[Dov Henis comment posted in TS, 2008-10-10]
http://www.the-scientist.com/blog/display/55081/

SC are more easily displaced during the organism's rest time simply because their genes and genome is off-duty then, part of the duty is to be on-call at the specific site where it is:

[b]"Life's Chirality And Circadian Rhythm,
Evidence Of Updated Darwinian Evolution" [/b]


[b]A. Updated life's concepts: [/b]

http://www.the-scientist.com/community/posts/list/20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd
stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis.

- Life's evolution is not random. It is biased, driven by culture.


[b]B. Earliest evidences of updated Darwinian evolution:[/b]

- Life's chirality
http://www.the-scientist.com/community/posts/list/122.page#387
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

- Circadian rhythm
http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299


[b]III.[/b]

[b]Circadian Rhythm-Metabolism Link Is Self-Explanatory[/b], and new "findings" are not required for suggesting that proper sleep and diet could help maintain or rebuild organism's "equilibrium" and for explaining why lack of proper rest, or disruption in our normal sleep patterns, is known to cause several unhealthy things in us and accelerate our aging process.


Suggesting,

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1243.page http://www.the-scientist.com/community/posts/preList/122/1243.page GMT [b]Money Printing Will NOT Cure The Technology Culture Greed Cancer[/b]


[b]A. "2008: Science news of the year"[/b]
http://www.sciencenews.org/view/feature/id/39395/title/2008_Science_news_of_the_year

Science News editors and writers survey the top news from the world of science in 2008. The selected stories are featured in this year-end issue, with 13 subjects'-links to the original stories.


[b]B. The subject of one of the 13 hotlinks to the full stories is "science and society",[/b]

and - unbelievable - the 2008 world-wide economy collapse YOK, it does not even exist there...no mention and no reflection or pondering on its nature, symptoms and cause.


[b]C. The world-wide economy can be saved ONLY by conceptual and factual renovation[/b] of the personal, social and societal values of the 1920s technology culture

Science and technology must be conceptually and administratively divorced from each other in order to renovate our culture, including economy.

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

Since the 1920s technology development has been THE TOOL of capital formation and accumulation, together with their inherent social and societal values, attitudes and life style and even together with their inherent individual and societal-social ethics.


[b]D. The Technology Culture Greed is neither a lofty nor an essential societal cultural ideal[/b] that must be maintained and upheld at all costs,

even if presently, at end 2008 and start 2009, we see a continuous pitiful obstinate inertial clinging of the greed-devotees to stock-markets activities all over the world. They just would'nt accept reality...


[b]E. Money printing will NOT cure the technology culture greed disease[/b]

Money printing in this state of affairs, like a blood transfusion in a terminal situation, will only enable temporary precarious respite, not cure. It would take a steadfast dedicated campaign of cultural inovation to save ourselves from collapse and proceed on a route of rational science culture.

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1254.page http://www.the-scientist.com/community/posts/preList/122/1254.page GMT

[b]A. A reply to one of my posts:[/b]

"Dov, you write: Life's evolution is not random. It is biased, driven by culture.

Be sure you understand that Darwin did not say that evolution is random. He said that evolution is not random. It is driven by natural selection."


[b]B. I never wrote anything that Darwin said. Here, again, is what I say and wrote: [/b]

Culture is the universal driver of genetic evolution

The major course of natural selection is not via random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased genes replication routes at their alternative-splicing-steps junctions, effected by the cultural feedback of the third stratum multicells organism or monocells community to their second and prime strata genome-genes organisms."

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1256.page http://www.the-scientist.com/community/posts/preList/122/1256.page GMT The Clock Is Innate Since Life's Day One
It's Culture That Drives Genetic Changes
And Culture Evolves Per Intelligence[/b]


[b]A. From "Hot clock key to fruit fly’s global spread"[/b]
http://www.sciencenews.org/index/generic/activity/view/id/39546/title/Hot_clock_key_to_fruit_fly%E2%80%99s_global_spread

"Widely distributed fruit fly species have a temperature-sensitive step in the manufacture of a key part in their biological clocks."

"The gear, a protein known as PERIOD, helps set the circadian clock in fruit flies and many other animals".


[b]B. The above abstract displays a deficit of some comprehensions[/b]

of the nature of the CLOCK and of the functional nature of the PROTEIN and of the PROTEIN'S ORIGIN.

The CLOCK is innate in genes-genomes, as genes are primal organisms and genomes are multiGenes organisms and as at genesis the ONLY source of activity energy for genes was the daylight's sun radiation. This is why sleep is a ubiquitous inherent organism's trait.

The functional nature of the protein is, as normal in biologic systems, a cue-tag to specific member(s) of the genome, the cooperative multiGenes communal organism, directing what-when to express, in this case "rest untill the temperature decreases to X degrees, then work".

This specific protein tag was produced by a specific gene at a biased alternative-splicing-step junction, effected by the cultural feedback of the fly, like in all normal evolutionary cases
in which a third stratum multicells organism or monocells community furnish cultural feedback to their second and prime strata genome-genes organisms as genetic evolution biasing instructions.

And the extent of the capability of the genes-genome to respond to the feedback and to effect the thus requested "mutation"-modification, the extent of this capability is the genome's INTELLIGENCE, its capability to assess survival experience and to react-respond to it.


[b]C. Life's Manifest[/b]
http://www.the-scientist.com/community/posts/list/112.page#578



Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1257.page http://www.the-scientist.com/community/posts/preList/122/1257.page GMT
[b]Sleep Is A Biological Enigma?
and
Sleep Protects Against Traffic Accidents[/b]


[b]A. From "A good night's sleep protects against parasites"[/b]

http://www.eurekalert.org/pub_releases/2009-01/bc-agn010709.php

- "Sleep is a biological enigma. Despite occupying much of an animal's life, and having been scrutinized by numerous experimental studies, there is still no consensus on its function".

- "When asleep, animals largely avoid....activities, and can thus allocate resources to the body's natural defenses."


[b]B. Sleep made simple: it is an inherent Earthlife trait[/b]

- Every organiasm sleeps because its genes-genomes sleep. And sleep is innate for genes because genes, being the first organisms evolved on Earth, came into being, born, by the sun's radiation energy absorbed by RNA-conformations oligomers, and the newborn genes were active ONLY when exposed to sunlight, which was then their only usable energy. Thus sleep is an inherent Earthlife trait.

- When asleep in bed, drivers largely avoid activities, and can thus allocate resources to the body's natural defenses against traffic and other accidents.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1314.page http://www.the-scientist.com/community/posts/preList/122/1314.page GMT

[b]"Structure mediating spread of antibiotic resistance identified"[/b]
http://www.eurekalert.org/pub_releases/2009-01/wt-sms010709.php


Horizontal (lateral) gene transfer is incorporation, in an organism, of genetic material from another organism without being the offspring of that organism (versus vertical transfer, when an organism receives genetic material from its ancestor). The transfer is by a 'secretion process', of elaborating and releasing materials from within a cell. This work elaborates the role of Type IV sub-system, a component of the secretion system.

'Mediate' is a transitive verb that means to effect by action as an intermediary, to transmit as intermediate mechanism or agency. Spread of antibiotic resistance proceeds by horizontal gene transfer, that produces extremely dynamic genomes in which substantial amounts of DNA are introduced into (and deleted from) the chromosome, by transformation or conjugation or transduction.

Nice work and elaboration. But I cringe involuntarily at references as 'DNA materials' to genes and/or genomes, and at implying that 'the cell' does anything. For me it has been obvious for many years that genes and genomes are organisms and that all structures within the outer cell membrane (OCM), including the OCM, are functional organs of the genes-genomes, that we are discussing the members (genes) of the spaceship (cell) team (genome)...


Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1317.page http://www.the-scientist.com/community/posts/preList/122/1317.page GMT [u][b]The Aging Chain[/b][/u]
[b]Aging genes age genomes age cells age cellular organisms And Vice Versa[/b]


[b]A. "Sirtuin shown to control gene activity"[/b]
http://www.sciencenews.org/view/generic/id/39788/title/Sirtuin_shown_to_control_gene_activity_
A previously overlooked protein called SIRT6 provides some molecular clues to aging.

Chua’s and Chang’s groups together show that SIRT6 works with a master regulatory complex called NFkappa-B to govern activity of genes associated with aging, inflammation, immunity and metabolism. When SIRT6 is missing, NFkappa-B becomes hyperactive and turns up activity of aging-linked genes.

Mostoslavsky believes many important body systems are affected by SIRT6, but cautions that the enzyme is not necessarily an anti-aging protein. The mutant mice lacking the protein have severe metabolic disturbances that could account for premature aging. Researchers have not yet detected any change in SIRT6 levels or activity with age.

“Whether this has a role in the normal aging process, we still don’t have enough information to answer that,” he says.


[b]B. Aging, lifetime and age[/b]

Aging = to become old, show the effects or the characteristics of increasing age, the increasing lifetime. The effects and characteristics of not only the totality of the system but also of each and every component and components of the components of the system. The system is the totality of the components.

lifetime = the duration of the existence of a living being, an organism, or an inanimate thing, a material, star or subatomic particle.

age = the length of an existence extending from the beginning to any given time.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1318.page http://www.the-scientist.com/community/posts/preList/122/1318.page GMT [b]Biological Evolution Discovered [/b]
[u][b]By Mathematicians And Evolutionary Ecologist[/b][/u]


[b]A. From "Mathematicians show how beetles can share a niche"[/b]
http://www.sciencenews.org/view/generic/id/39715/title/Mathematicians_show_how_beetles_can_share_a_niche
New equations help solve decades-old puzzle of why one species does'nt always outcompete another.

Placing two species of flour beetle in the same jar of flour needn't always result in one species driving the other to extinction. A new mathematical model shows how sometimes these two competing species can coexist.

"It opens some questions about this dogmatic view in ecology...It reopens the issue of what you consider a niche to be."

In the novel illuminating case researchers noted a small evolutionary change in the traits of the beetles. They sometimes eat the eggs of their own species as well as those of closely related species. In this case they evolved to become more-voracious egg eaters.

Cushing and his colleagues designed a mathematical model that, unlike previous models, allowed the egg-eating trait to evolve — which affected the birth and death rates of each species. Neither species went extinct after more than 30 generations.

What makes this work very, very exciting, comments an evolutionary ecologist, is that it shows how just a tiny bit of evolution might actually explain the results... (end quotes)


[b]B. What a thrilling scientific discovery![/b]

How just a tiny bit of evolution might actually explain the results...the co-existence of competing species...

Wow! this may explain why in some niches some competing species struggle violently whereas in others they coexist thrivingly! And just think that this may apply to so many types and sizes of niches and to so many species! Wow! It may apply even to human societies!



Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page]]> http://www.the-scientist.com/community/posts/preList/122/1354.page http://www.the-scientist.com/community/posts/preList/122/1354.page GMT [u][b]And On The Sad State Of Life Sciences In 2009[/b][/u]


Re "Stanford researchers show adaptation plays a significant role in human evolution"
http://www.eurekalert.org/pub_releases/2009-01/su-srs011409.php


1) "For years researchers have puzzled over whether adaptation plays a major role in human evolution or whether most changes are due to neutral, random selection of genes and traits."

- I have been presenting evidence for years that adaptation, i.e. culture, is the driver of evolution of all life including human and, yes, of all other materials, and that genetic evolution is generally biased, not random.

2) "Geneticists at Stanford now...show adaptation, the process by which organisms change to better fit their environment, is indeed a large part of human genomic evolution."

- Shortly after retiring from industrial consulting (1956 - 1998) I started investigating the state of comprehension of the nature of life and of its evolution and I published evidence and conclusion that culture is the driver of all genomic evolution.

3) "Others have looked for the signal of widespread adaptation and couldn't find it...now...we were able to detect the adaptation signatures quite clearly"

- I found the evidence many years ago and presented it clearly in my postings.

4) "All genetic mutations start out random, but those that are beneficial to an organism's success in their environment are directly selected for and quickly perpetuate throughout the population, providing a uniform, traceable signature."

- NO NO NO. The drive of evolution is NOT RANDOM followed by survival selection. It is biased, as explained in my "Life's Manifest" and elaborated in my posts about the role of culture in evolution.

5) "Humans have a very complex history from traveling around the globe, and the human genome is also highly structured, making it complicated and difficult to work with, he said."

- The human genome, like all other genomes, is complicated, being a multi-genes organism, an organism that consists of a cooperative commune of the smaller Earth's primal organisms, namely of genes.

6)"Adaptation becomes widespread in the population very quickly," Petrov said. "Whereas neutral random mutation doesn't and would not have the selective sweep signature."

- Bravo. This happens to be a correct statement. Random mutations are mechanical accidents that the organism may or may not overcome to survive.


I stop here. No patience nor interest to continue picking at each of the following paras. Just sadly frustrated at The Sad State Of Life Sciences In 2009...


Respectfully yours,

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
]]> http://www.the-scientist.com/community/posts/preList/122/1382.page http://www.the-scientist.com/community/posts/preList/122/1382.page GMT

[b]A. SN Special : Darwin turns 200[/b]
http://www.sciencenews.org/view/feature/id/39754/title/SN_Special__Darwin_turns_200
This special web edition of Science News includes expanded versions of articles from the magazine's print edition plus two additional features, all commemorating the 200th anniversary of the birth of Charles Darwin.


[b]B. 22nd Century Conception Of Unified Field Theory And Evolution[/b]

The following brief essays present the 22nd century comprehension of evolution. They preserve Darwin's name in reference to Life Evolution in respect and appreciation of Darwin's promotion of the concept of evolution in life.

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page

Life And Darwinian Evolution, 21st Century Comprehension
http://www.the-scientist.com/community/posts/list/112.page

Rethink Unified Field Theory And Evolution
http://www.the-scientist.com/community/posts/list/60/122.page#982


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1384.page http://www.the-scientist.com/community/posts/preList/122/1384.page GMT

[b]A. "Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome"[/b]
http://www.eurekalert.org/pub_releases/2009-01/jhmi-gss011209.php

CpG islands are DNA regions containing a high frequency of CpG (cytosine-phosphodiester-guanine) dinucleotides, 300-3,000 base-pairs long in mammalians, often in-near 'promoters' of mammalian genes.

[b]"Epigenetic finding adds insight on how cells become brain, liver or malignant"[/b]
http://www.eurekalert.org/pub_releases/2009-01/jhmi-lds011209.php


[b]B. From "Epigenetic Heredity Comprehension Advanced"[/b]
http://www.the-scientist.com/community/posts/list/80/122.page#1118

These above works are outstanding, yet could be more elaborative and revealing if gene-genome are realized to be the organisms they are.

One day, maybe yet in the 21st century, science will look back with amused disbelief at old terms and concepts like "letters of the DNA sequence" and "epigenetic information", in regards to genes-genome organisms...


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1404.page http://www.the-scientist.com/community/posts/preList/122/1404.page GMT

[b]I.[/b]
At Darwin 200
[b]Darwin Extended Beyond His Own Horizon[/b]
Rethought Unified Field Theory And Evolution

[b]A.[/b] SN Special : Darwin turns 200
http://www.sciencenews.org/view/feature/id/39754/title/SN_Special__Darwin_turns_200
This special web edition of Science News includes expanded versions of articles from the magazine's print edition plus two additional features, all commemorating the 200th anniversary of the birth of Charles Darwin.

[b]B.[/b] 22nd Century Conception Of Unified Field Theory And Evolution

The following brief essays present the 22nd century comprehension of evolution. They preserve Darwin's name in reference to Life Evolution in respect and appreciation of Darwin's promotion of the concept of evolution in life.

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page

Life And Darwinian Evolution, 21st Century Comprehension
http://www.the-scientist.com/community/posts/list/112.page

Rethink Unified Field Theory And Evolution
http://www.the-scientist.com/community/posts/list/60/122.page#982


I[b]I.[/b]
[b]Evolution beyond Darwin 200[/b]

Per "Design And Randomness In Cosmic And Life Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=404

Singularity and D-Infinity (max expansion, energy dilution) are the cosmic end states. Their in-between is a metastable state. This corresponds to commonsense observation: the denser the compacting goal of material the more energy is required, and vice versa the more thorough the disintegration of material the higher the amount of energy released. It seems that the cosmic universal process is E=Total[m(1+D)] , where D is the Distance from Big Bang point and the sum is of all spatial values of D from D=0 to D=selected value.

Presently the cosmos expands on the right side of the equation. However, within its accelerating overall energy dilution there are local phenomena of formation of temporarily constrained energy pockets that evolve backwords towards impansion. The two most obvious examples of such backword energy constraints are black holes and life, two distant relatives within a probably big family of various forms of cosmic 'backlash energy constraints'.


Suggesting,

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1407.page http://www.the-scientist.com/community/posts/preList/122/1407.page GMT


[b]A. "Checklist reduces surgery complications"[/b]
http://www.sciencenews.org/view/generic/id/39871/title/Using_checklist_reduces_surgery_complications
Measure twice, cut once: Going over a checklist of procedures in the operating room before and after surgery lowers the complication rate and, in developing countries, saves lives, a study in eight hospitals shows.


[b]B. A Probable Natural Paradigm...[/b]

From "How Decisions Are Made Within The OCM (outer cell membrane)"
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry325606

... the genome behaves not as being presided by a decider President Gene, but by innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
]]> http://www.the-scientist.com/community/posts/preList/122/1411.page http://www.the-scientist.com/community/posts/preList/122/1411.page GMT [b]Re-think-plan-do-assess Sleep Melatonin works.[/b]

[u][b]Sleep, Melatonin, Cancers And Beyond Darwin 200[/b][/u]


[b]I.[/b]

[b]Darkness, melatonin may stall breast and prostate cancers [/b]
http://www.sciencenews.org/view/generic/id/40170/title/Darkness%2C_melatonin_may_stall_breast_and_prostate_cancers_
New studies suggest strong links between melatonin and breast and prostate cancers.

Melatonin is a hormone produced in the pea-size pineal gland in the center of the brain, secreted at night or in the dark. It is used to regulate the sleeping cycle and also found to correlate with other functions and problems in the body.


[b]II.[/b]

[b]Sleep and chirality are biological evolution evidence that genes are organisms [/b]

From "Circadian Rhythm-Metabolism Link Is Self-Explanatory"
http://www.physorg.com/news136122147.html

[b]"Circadian rhythm-metabolism link discovered"[/b] ?
http://esciencenews.com/articles/2008/07/24/circadian.rhythm.metabolism.link.discovered

The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process.


[b]II.[/b]

[b]Circadian-rhythm is the genes' innate rest time,[/b]

which - together with life's chirality - are the earliest evidences of Darwinian life evolution, the evolution of the primal, 1st stratum, Earth organisms, the genes.

[b]From "SC displaced more easily when off-duty":[/b]

"It is unclear why the stem cells leave their niche during a patient's time of rest"
[Dov Henis comment posted in TS, 2008-10-10]
http://www.the-scientist.com/blog/display/55081/

SC are more easily displaced during the organism's rest time simply because their genes and genome are off-duty then, part of the duty is to be responsively on-call at the specific site where they are:

[b]"Life's Chirality And Circadian Rhythm, Evidence Of Updated Darwinian Evolution"[/b]

A. Updated life's concepts:

http://www.the-scientist.com/community/posts/list/20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis.

- Life's evolution is not random. It is biased, driven by culture.


B. Earliest evidences of updated Darwinian evolution:

- Life's chirality
http://www.the-scientist.com/community/posts/list/122.page#387
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

- Circadian rhythm
http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299


[b]III.[/b]

Circadian Rhythm-Metabolism Link Is Self-Explanatory, and new "findings" are not required for suggesting that proper sleep and diet could help maintain or rebuild organism's "equilibrium" and for explaining why lack of proper rest, or disruption in our normal sleep patterns, is known to cause several unhealthy things in us and accelerate our aging process.


Suggesting,

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1412.page http://www.the-scientist.com/community/posts/preList/122/1412.page GMT [b]The Aging Whole Being A Construct Of Its Constituents[/b]


[b]A. "As cells age, the nucleus lets the bad guys in"[/b]

http://www.sciencenews.org/view/generic/id/40136/title/As_cells_age%2C_the_nucleus_lets_the_bad_guys_in

A study tracks a growing 'leakiness' in the membrane of the cell nucleus that could contribute to aging and even to diseases such as Parkinson's and Alzheimer's.

[b]B. The nucleus membrane is an organ, a functional organ of the genome organism[/b]

All biological materials, of all forms, 'age'-change with time and with environments-circumstances. The list of possible age-related pore-leakiness effectors comprises a variety of 'aging' facors that continuously modify the functionality of the pore and modify also the characteristics of the constituents of the inventory of materials within the outer cell membrane, the largest organ of the genome.

[b]C. "Aging Not Approachable With Oversimplification". Aging Is A Closed Chain. [/b]

http://www.the-scientist.com/community/posts/list/100/122.page#1318

Aging genes age genomes age cells age cellular organisms and vice versa, the whole WHOLE being a construct of its constituents...


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1422.page http://www.the-scientist.com/community/posts/preList/122/1422.page GMT [u][b]Melatonin Switches On Mostly Intercell Maintenance[/b][/u]
[b]Wake up. [/b]
[b]Re-think-plan-do-assess Epigenetics, Sleep And Melatonin works. [/b]


[b]A. "Epigenetics reveals unexpected, and some identical, results"[/b]
http://www.sciencenews.org/view/generic/id/40060/title/Epigenetics_reveals_unexpected%2C_and_some_identical%2C_results
One study finds tissue-specific methylation signatures in the genome; another a similarity between identical twins in DNA’s chemical tagging.

I humbly suggest : Re-think-plan-do-assess Epigenetics Works, founded on scientific conception that genes and genomes are organisms.


[b]B. "Sleep, Melatonin, Cancers And Beyond Darwin 200"[/b]
http://www.the-scientist.com/community/posts/list/100/122.page#1412

I humbly suggest: Re-think-plan-do-assess works, founded on scientific conception that genes and genomes are organisms.


[b]C. Apparent functional aspects of melatonin[/b]
http://cogweb.ucla.edu/ep/Neurology.html#Melatonin

Melatonin is a hormone secreted by the human pineal gland during night-time darkness, and it is now being marketed in the US as a nutritional supplement. The hormone is an indoleamine compound derived from the amino acid *tryptophan, with *serotonin as an intermediate precursor.

1) The most important role of melatonin in all species is to provide a hormonal signal of night-time darkness. The secretion of the hormone is tightly controlled by the *circadian pacemaker. 2) Melatonin is a phylogenetically ancient hormone, found even in some single-cell organisms and in some plants. 3) At the cellular level, melatonin receptors are members of the superfamily of *G protein-coupled receptors...Activation of these receptors inhibits *cyclic AMP production by the enzyme adenylyl cyclase.

cAMP (cyclic AMP) acts as an intracellular hormone (i.e., a chemical messenger). Cyclic AMP is derived from ATP in a reaction catalyzed by the enzyme adenylyl cyclase (also called adenyl cyclase and adenylate cyclase).

I humbly suggest: Melatonin, the phylogenetically ancient hormone, was evolved by the genome during the early single-cells eons when they evolved community life cultures and graduated from sunlight-only to metabolism-too energy production. Melatonin's role was to signal that the genes are asleep, their functional activities are shut off, and it is time for the security and maintenance crews to do their tasks, especially to clean up the intercell environment, for keeping the community of cells in proper state.


[b]D. It all adds up to:[/b]

Gene: a primal Earth's organism. (1st stratum organism)
Genome: a multigenes organism consisting of a cooperative commune of its member genes. (2nd stratum organism)

"Life's Manifest"
http://www.the-scientist.com/community/posts/list/112.page#578


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1433.page http://www.the-scientist.com/community/posts/preList/122/1433.page GMT Re [u][b]The Required Economy Collapse Cure[/b][/u]
[b]It's Not Just The Economy, It's The Technology Culture That Collapsed[/b]


[b]A. Brief notes re the apparent major aspects of the collapse [/b]


1) Jan 6 2009

What Is "Scientific Progress"
What Is Needed To Advance Science
http://www.physforum.com/index.php?showtopic=14988&st=390&#entry392722


2) Dec 24 2008

For 2008 Sciencenews Of The Year YOK The World-Wide Economy Collapse
Money Printing Will NOT Cure The Technology Culture Greed Cancer
http://www.physforum.com/index.php?showtopic=14988&st=390&#entry390280


3) Dec 22 2008

Separate Technology From Science To Renovate Our Culture Including Economy
http://www.physforum.com/index.php?showtopic=14988&st=375&#entry390004


4) Nov 21 2008

Real And Virtual Energy, And Keynesian Salvation Prospects
http://www.physforum.com/index.php?showtopic=14988&st=345&#entry384952



[b]B. There are no short-cuts for effecting a cure of the malignant world economy greed cancer.[/b]

From the above (4) ref:

"The present tone of the world's culture, and even ethics, including the banners of a variety of types and shades of greed, has been set by the 20th century Technology Culture. Its essence is the legitimacy and admiration of gaining capital via virtual activities, activities without or beyond the production of real assets, real life resources.

So the odds of the economy's salvation via Keynesian prospects are, in the long run, proportional to the odds that the culture of Earth's humanity will evolve towards ever more rational self-organization...which is, how unsurprisingly rational, the odds of every organism to survive..."

There are no short-cuts for effecting a cure of the malignant world economy greed cancer. The cure and recovery from this cancer entails a steady resolute cultural modification of 20th century personal and societal capitalistic greed values-ethics-morals. It entails public education to value and promote legitimacy and respect only of shares-stocks of products and processes that contribute to health, security, basic comfort, education and science, and to reject and shun products and processes involved in any form of luxuriousness.

And it entails a steady resolute continuous promotion of respect to non-luxurious life style and to pursuit by science, of convincing, ever closer approaching, approximate models of the real world including life and ourselves. This would be a return to and furthering of Enlightenment's inherent philosophy and attitudes in regards to individualism, universal human progress and, most important to humanity, the applications of reason.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1447.page http://www.the-scientist.com/community/posts/preList/122/1447.page GMT

[b]A. Newborns pick up the beat[/b]

http://www.sciencenews.org/view/generic/id/40245/title/Newborns_pick_up_the_beat
Electrical measurements of sleeping newborn babies’ brains indicate that the 2- to 3-day-olds automatically detect a regular beat in rhythmic sequences, possibly reflecting an early capacity for learning music.


[b]B. Why Music Touches Us[/b]
Nov 11 2005, in biologicalEvolution forum

http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=184

My conjecture about music 'touching-moving' us:

Music is a human cultural-artifactual elaboration of creatures' vocal communication which is an extension-elaboration of >24 wks-old in-womb fetus' and of newborns' intimate safe-coddle-sooth experiences. Both 'touch' and 'hear' senses are founded on mechanical sensing processes involving in-cell ions leakage forming electrical action potentials interpreted neurologically. I suggest-conjecture that the same neurological constellation may be handling both 'touch' and 'hear' senses, being of commom mechanisms and differing essentially only in switch-on modes, and that this evolves in all vocal creatures in conjunction with in-womb safe-feeling, and later with baby codling-handling and vocal soothing-communicating, and later also with intimate emotional implications. Hence music has 'engulfing-touching-emotional' connotation and individual's music orientation has childhood-ethnic rootings.

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1469.page http://www.the-scientist.com/community/posts/preList/122/1469.page GMT [b]Ameisen Olivier, Imagination Medicine,[/b]
[b]Placebo, God-Religion, Virtual Reality[/b]

(recapitulation of some earlier posts)


[b]A. Anti-Depressants, like[/b]

- Ameisen Olivier's "end of my addiction"

- http://www.completehealthdallas.com/Anti-DepressantsNaturalAlternativeDallas.html

- http://www.answers.com/topic/serotonin


[b]B. Imagination Medicine[/b]

http://www.sciencenews.org/view/feature/id/39046/title/Imagination_Medicine
Brain imaging reveals the substance of placebos. Expectation alone triggers the same neural circuits and chemicals as real drugs.

"It all boils down to expectation. If you expect pain to diminish, the brain releases natural painkillers. If you expect pain to get worse, the brain shuts off the processes that provide pain relief. Somehow, anticipation trips the same neural wires as actual treatment does.

Scientists are using imaging techniques to probe brains on placebos and watch the placebo effect in real time. Such studies show, for example, that the pleasure chemical dopamine and the brain’s natural painkillers, opioids, work oppositely depending on whether people expect pain to get better or worse. Other research shows that placebos can reduce anxiety."


[b]C. Placebos: some background info[/b]

http://www.cerebromente.org.br/n09/mente/pavlov_i.htm
http://www.cerebromente.org.br/n09/mente/placebo1_i.htm
http://thjuland.tripod.com/placebos.html

The concept of a placebo comes from medieval times, when professional mourners were paid to stay by the bedside of. deceased person, reciting a psalm beginning "Placebo Domino..." or "I shall please the Lord." "Placebo" gradually became the word used for the paid mourner, whose grief was, in fact, false.


[b]D. Life's Manifest[/b]

http://www.the-scientist.com/community/posts/list/112.page#578

Genes are the primal, 1st stratum, Earth's organism and genomes are 2nd stratum organisms,
multigenes consisting of cooperative communes of their member genes.

Life is a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.


[b]E. On Science and Religion[/b]

"Evolutionary Biology Of Culture And Religion"
http://www.the-scientist.com/community/posts/list/20/122.page#492

The concept “God” is a human virtual reality artifact, experienced only through sensory stimuli. Preoccupation with god-religious matters within a scientific frameworks contributes to corrosion and corruption of science and scientism by manifesting or implying acceptance of virtual reality as reality.

Everything is discussable scientifically. No limit. Including virtual matters and affairs. But for a scientific discussion the framework must be clearly defined. The totality of subjects that come under the classification "virtual" are not an exception. You can include in the discussion Pavlov and the modes and manners of exploiting virtuality in any area and towards any end.


[b]F. So why Pavlov smiled in 2008?[/b]

Pavlov demonstrated effecting placebo phenomena in multicelled organisms by manipulation of their drives-reactions. Now placebo and imagination phenomena are demonstrated also in the smaller organisms, in the genes and genomes of multicelled organisms, in our primal first stratum and 2nd stratum base organisms. A very good reason to smile.

Now an interesting chain is exposed to our view, the Genes-Virtual Reality Chain, a most intriguing cultural evolution chain extending from the genesis of our genes to nowadays, throughout life, a virtual reality existence, and by virtual reality phenomena, exploitations and manipulations.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1475.page http://www.the-scientist.com/community/posts/preList/122/1475.page GMT [u][b]But With Confused Terminology[/b][/u]


[b]A. From "Animal ancestors may have survived ‘snowball Earth’"[/b]
http://www.sciencenews.org/view/generic/id/40580/title/Animal_ancestors_may_have_survived_%E2%80%98snowball_Earth%E2%80%99
Chemical fossils in Precambrian sedimentary rock push back the first date for animal life.

1) Finding a molecule that was made by an organism, means that the biosynthetic ability to make that molecule must have evolved earlier than the Cambrian period, which extended 544 to 500 million years ago with marine invertebrates. Biosynthetic ability had to be around by at least 635 million years ago and, the researchers say, maybe as early as 751 million years ago.

2) There’s evidence of eukaryotic life, organisms with DNA sequestered in a protective nucleus, from roughly 1.9 billion years ago, but proper multicellular animals don’t appear on the scene until much later.


[b]B. Confused terminology[/b]

The report mostly and clearly attributes ONLY to multicells organisms the terms animal ancestors, animal life, organism, biosynthetic ability. Yet it terms also an 'organism' a maybe, probable, 1.9 billion yrs old 'eukaryotic life', even if implying that it might have not been 'proper multicellular animals'.


[b]C. Suggested clarification of scenario and terminology[/b]

From "Life's Manifest"
http://www.the-scientist.com/community/posts/list/112.page#578

- First were independent individual genes, Earth's primal organisms.
- Genes aggregated cooperatively into genomes, multigenes organisms, with genomes' organs.
- Simultaneously or consequently genomes evolved protective and functional membranes, organs.
- Then followed cellular organisms, with a variety of outer-cell membrane shapes and
functionalities.
- Cellular organisms (3rd stratum organism): mono- or multi-celled earth organisms.

Since evolution is definitely driven by culture, the evolution of multicelled organisms was preceded by evolution of cooperative community life culture of the monocelled organisms. Most presently observed biological processes and internal organs in multicelled organisms have originated and evolved by and during the evolution of the cooperative community life culture of the monocelled organisms...


Suggesting,

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1494.page http://www.the-scientist.com/community/posts/preList/122/1494.page GMT

[b]A. "Google peer review"[/b]
http://www.the-scientist.com/community/posts/list/380.page#1497

Seeks comments on "crowd-sourcing the peer review process".


[b]B. Enhancing Peer Review (NIH/OD) [/b]
Sent:Jan 03, 2009
To: henisdov
Subject:Peer Review And Innovation

Dear Dov Henis,

Thank you for your input. Please be aware that a significant part of
the process to Enhance Peer Review is "Continuous Review of Peer
Review." We will keep your comments under consideration.

The Enhancing Peer Review Team
http://enhancing-peer-review.nih.gov
"...fund the best science, by the best scientists, with the least amount
of administrative burden."


[b]C. From earlier postings of mine:[/b]

"Peer Review" is, factually, a tool of a "Subversive Activities Control Board", a tool of the Science Establishment.

The most revolting corrupt aspect of peer review in science is its exploitation by the Science Establishment to tightly clamp its political and financial omni-everything power, rule, control and censorship, including stifling of any shred of scientific innovation not originated or not publicized via The Establishment's network.

The corruption is not inherent in the tool, but in the nature of the Science Establishment and in the characteristics of its obsequious functionaries.

"Implications Of Science And Technology Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419

The AAAS and its affiliates and equivalent organizations, i.e. all the Science Establishment Guilds, loudly and pseudoscientifically promote and "profoundly respect" the "spiritual religious domain" as a real domain, a domain separate from the real science domain. They do this both because, unbelievably, they actually believe it and as a politically powerful tool in promoting towards themselves public esteem-acceptance and state-public financial support.

The peer review process is a tool of the Establishment. As long as the Science Establishment Guilds are what they now are and as long as they enjoy the public and state esteem they now have, and as long as Science and Technologhy are not seperated from each other conceptually and administratively but considered and handled as one faculty, the corruption of science cannot and will not be overcome. These 21st century technology culture aspects have been well inscribed and entrenched by Science's Big Brothers in the minds and conceptions of the public.


[b]D. The lesson of the wikipedia-encyclopedia's "public-sourcing" product[/b],

and of additional currently on-line "outside-Establishment-sourcing" science publishing start-ups is discouraging. IMO the GPeerReview is destined to end up similarly, i.e. as a cheaper, more available, second-hand product proudly claimed to be produced with the Establishment's rules-regulations-considerations even if "made in China" for faster and cheaper delivery and for more wide-spread availability.

Thus science publishing delivery will become faster and cheaper but the products will be made and cleared with today's combination of writing rules-regulations and peer-review ecclestiasticism that have been so deeply inscribed in the flock of the 21st century Science Establishment Church.


Dov Henis

(A DH Comment From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1]]> http://www.the-scientist.com/community/posts/preList/122/1498.page http://www.the-scientist.com/community/posts/preList/122/1498.page GMT [b]re Darwin's 200 finds just 39% of Americans 'believe' in evolution[/b]

http://firstread.msnbc.msn.com/archive/2009/02/12/1791814.aspx

The language and terms of this Gallup poll is a glaring example of...meaningles mumbo-jumbo...

A proper poll would present a brief scientific definition-description of Life's Evolution, summarized in numbered sentences or paras, and solicit YES-NO- ACCEPT of each of them.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1508.page http://www.the-scientist.com/community/posts/preList/122/1508.page GMT [u][b]Survival Requires Sacramentalism, Not Rationalism[/b][/u]
[b]Pseudoprofound Gibberish[/b]


[b]A. Biologist discusses sacred nature of sustainability[/b]
http://www.eurekalert.org/pub_releases/2009-02/wuis-bds021109.php


[b]B. From my earlier postings:[/b]

- It's The AAAS That Promotes Religion In Science And In Law
The AAAS and its affiliates and equivalent organizations, i.e. all the Science Establishment Guilds, loudly and pseudoscientifically promote and "profoundly respect" the "spiritual religious domain" as A REAL domain, a domain separate from the REAL, science, domain. They do this both because,[i] unbelievably, they actually believe it [/i]and as a politically powerful tool in promoting their power and state-public support.

- On Science and Religion
"Evolutionary Biology Of Culture And Religion"
http://www.the-scientist.com/community/posts/list/20/122.page#492

Religion is a human virtual reality artifact, experienced only through sensory stimuli. Preoccupation with religious matters within a scientific frameworks contributes to corrosion and corruption of science and scientism by manifesting or implying acceptance of virtual reality as reality.
Everything is discussable scientifically. No limit. Including virtual matters and affairs. But for a scientific discussion the framework must be clearly defined. The totality of subjects that come under the classification "virtual" are not an exception. You can include in the discussion Pavlov and the modes and manners of exploiting virtuality in any area and towards any end.

- Why Pavlov smiled in 2008

Pavlov demonstrated effecting placebo phenomena in multicelled organisms by manipulation of their drives-reactions. Now placebo and imagination phenomena are demonstrated also in life's base organisms, in the genes and genomes of multicelled organisms, in our primal first stratum and 2nd stratum base organisms. A very good reason to smile.

Now an interesting chain is exposed to our view, the Genes-Virtual Reality Chain, a most intriguing Cultural Evolution Chain extending from the Genesis of genes to nowadays organisms' cultures, throughout life, which is a virtual reality existence, the cultures are evolving by virtual reality phenomena, exploitations and manipulations.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1515.page http://www.the-scientist.com/community/posts/preList/122/1515.page GMT [u][b]Via "New Masters of Science"[/b][/u]


[b]I. AAAS: The New Masters of Science [/b]
http://www.sciencenews.org/view/generic/id/40906/title/AAAS_The_New_Masters_of_Science_
A new master's degree program is emerging that is creating "a new type of scientist" and a new professional class.

[b]
II. From "Societal Implications Of Science And Technology Evolution" [/b]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419
Science And Technology Evolution Since The 1920s, And Its Societal-Social Implications

I posit that the nature of the evolution of science and technology since the 1920s has been the most significant molding factor of the present characteristics of our society, and that it is vitally important for charting the future course of our society to learn and understand this evolution.

A. Science and technology are clearly and distinctly two separate faculties, separate branches of learning and teaching. Yet since the 1920s the titles of these different faculties appear inseperably jointly everywhere.

B. Why is it that since the 1920s technology has been evolving dynamically whereas basic, non-applied, science has been progressing - in my opinion - at ever decreasing rate?

C. And what have been and what are the societal-social implications of the format of this evolution and of the present state of science and technology?

D. Definitions of terms for the subject of this thread:

- Science: state of knowledge attained by systematized thinking, studies and/or tests through established scientific methods.

- Technology: capability of and manner of practical application of knowledge.


[b]III. It appears that the mundane term "technician of science" is a threat to the AAAS[/b]

Looks like the AAAS resorts to a virual-reality public-relations manipulation, to "Masters of Science" in lieu of the obviously factual plain and simple "technician of science", in order to allay apprehension that "technician of science" might have deleterious effects on its size and esteem and public impact...

[i]Hypocrisy, hypocrisy...[/i]

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/1523.page http://www.the-scientist.com/community/posts/preList/122/1523.page GMT [b]Foresaw Pavlov[/b]


[b]A. For gamblers' brains, almost counts [/b]
http://www.sciencenews.org/view/generic/id/40735/title/For_gamblers_brains%2C_almost_counts_
In an experiment mimicking slot machines, people’s brains reacted similarly to almost winning as to winning, possibly explaining why gambling can be addictive.


[b]B. From :Pavlov's Smile[/b]
http://www.the-scientist.com/community/posts/list/100/122.page#1475

So why Pavlov smiled in 2008?

Pavlov demonstrated effecting placebo phenomena in multicelled organisms by manipulation of their drives-reactions. Now placebo and imagination phenomena are demonstrated also in the smaller organisms, in the genes and genomes of multicelled organisms, in our primal first stratum and 2nd stratum base organisms. A very good reason to smile.

Look at [i]"Life's Manifest" [/i] and at [i]"EVOLUTION Beyond Darwin 200"[/i] and reflect about them...

Now an interesting chain is exposed to our view, the Genes-Virtual Reality Chain, a most intriguing cultural evolution chain extending from the genesis of our genes to nowadays, throughout life, which is a virtual reality existence, and by virtual reality phenomena, exploitations and manipulations.


Dov Henis
(Comments From The 22nd Century)

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1568.page http://www.the-scientist.com/community/posts/preList/122/1568.page GMT [b]Maybe Scientists Should Propagandize As Religionists Do[/b]


[b]A. Maybe Scientists should propagandize as religionists do[/b]
http://www.physforum.com/index.php?showtopic=25187&st=0&#entry401928


[b]B. For the AAAS science is a companion religion to "spiritual" personal religions[/b]

For the AAAS, the organization and Establishment Guild of our "scientists" (whatever this term means), for many many years science has been a religion, too, a "universal religion" besides and in addition to the "spiritual" personal religions.

The AAAS apparently considers that thus having two religions is in accordance with one of the Merriam-Webster (1827) definitions of rationalism, i.e.: "reliance on reason as the basis for establishment of religious truth". (wondering what was "religious truth" when this definition was drawn up, before understanding that religious truth is a virtual reality affair?)

But by adopting this meaning of rationalism AAAS disregards the other meanings of rationalim:

- "a theory that reason is in itself a source of knowledge superior to and independent of sense perceptions". (an 1827 unwitting reference to virtual reality...)

- "a view that reason and experience rather than the nonrational are the fundamental criteria in assessing and solution of problems"


[b]C. So, should science be evangelized? [/b]

So why, then, should'nt the AAAS take one step further and embark on explicit evangelizing of science as "the basis for religious truth" in accordance with its hitherto implied-only tenet?

This would be an interesting field trial project in our present virtual reality 21st century technology culture concurrent with the present struggle to survive the collapsed virtual reality basis of this culture's economic tenets.


Dov Henis
(Comments From The 22nd Century)

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1574.page http://www.the-scientist.com/community/posts/preList/122/1574.page GMT [b]More On The 2009 Life Sciences March[/b]


[b]A. "Jumping genes provide unexpected diversity"[/b]
http://www.sciencenews.org/view/generic/id/40922/title/Jumping_genes_provide_unexpected_diversity
Mobile DNA elements have stuffed and shrunk the human genome, a comparison of two genomes reveal


[b]B. Pearls of new scientific insights[/b]

- "Mobile DNA elements help shape human genomes"
- "Mobile pieces of DNA may have given humans a jump-start on evolution, a new study reveals"
- "... genes have been actively shaping human and other primate evolution"

Unbelievable indeed! Exciting unexpected new scientific insights!


[b]C. Common current misconception...[/b]

- "Jumping genes, pieces of DNA that replicate and insert themselves into a host’s genome..."

Whereas genes are organisms, originally independent organisms that evolution rendered capable of surviving only interdependently as functional members of cooperative gene communes, i.e. genomes.


[b]D. The "researchers" compared TWO genomes[/b],

one was the genome of a specific person, J.C. Venter, and the other was the genome "assembled" by Venter's Human Genome Project.

Compared with the "assembled" genome, in the genome of the specific person they found 706 places into which "transposable elements had stuffed extra DNA" while in the stuffing process recombinations between the mobile elements cut 140 chunks out.

In view of this they state: "The finding indicates that transposable elements are unexpectedly potent contributors to human genetic diversity..." and “We’re finding more and more variability than we would have predicted”...

Brilliant and exciting indeed...Life Science Marches On!


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1579.page http://www.the-scientist.com/community/posts/preList/122/1579.page GMT [u][b]More Superfluous Research[/b][/u]


[b]A. From "Hitting the redo button on evolution"[/b]
http://www.sciencenews.org/view/generic/id/40649/title/FOR_KIDS_Hitting_the_redo_button_on_evolution
Scientists are experimenting with bacteria to see if evolution plays out the same way every time.

Some "scientists" think that in a redo of evolution things would turn out basically a repeat, with maybe some different details. Others don’t agree. They think that in a redo a small change somewhere along the line could produce very big changes later.

The point of this "experiment" was to settle the 'debate', "to see if evolution plays out the same way every time".


[b]B. The debate subject is futile, pointless, and so is the experiment,[/b]

since it is plainly obvious that:

- any redo of any evolution scenario, especially in bio systems, cannot ever be exact. This is plainly obvious and does not need elaboration.

- it is impossible to quantify comparative changes between bio evolution redo's , nor to guesstimate what 'later' changes may be.


[b]C. Such pointless superfluous doings do not contribute anything to comprehension of evolution[/b]

I have been presenting evidence for years that adaptation, i.e. culture, is the driver of evolution of all life including human and that genetic evolution, the primal genes' functional modifications, expressions, are generally not random constitutional phenomena but occur in biased courses set-directed by the cultural feedback of the parent multicell organism ( or the monocells community ) to the membership of their genome.


Dov Henis
(Comments From The 22nd Century)

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1588.page http://www.the-scientist.com/community/posts/preList/122/1588.page GMT
[quote]QUOTE (HenisDov @ May 18 2007, PhysOrg Forum)
A. If one accepts, intuitively and logically, Pasteur's observation .... We are just beginning to comprehend the nature of the raw material called Life and that the purpose of OUR life is ours to choose and develop and follow.
Dov [/quote]

I am asked, by TracerTong, two questions:

[b]A.[/b] Shouldn't it (life's genesis) be repeatable? Wouldn't scientists have already been able to repeat it?

[b]B.[/b] What about spiritual happenings? Is it logical to assume only natural?


My answers:

[b]A.[/b] Today's "scientists" are unable to "repeat it" because (1) they do not know how the first "life" arose and (2) they do not and will never know and will not be able to duplicate the environments and circumstances of genesis and (3) they do not and will never know and will never be able to repeat the environments and circumstances of post genesis evolution.

[b]B.[/b] "Spiritual happenings" are virtual reality affairs. They are feasible only for living organisms that have a culture, i.e. that have a pattern of sensings and reactions to the sensings. Genes, and therefore also genomes, are organisms and display virtual reality phenomena, therefore also multicelled organisms, like dogs and humans, display such "spiritual" phenomena.


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1596.page http://www.the-scientist.com/community/posts/preList/122/1596.page GMT

[b]A. Relevant definitions of terms:[/b]

Real: not artificial or illusory, occurring or existing in actuality as a physical entity, having objective independent existence.

reality: the quality or state of being real, a real event, entity, or state of affairs, the totality of real things and events.

Virtual: being such in essence or effect though not formally recognized or admitted, hypothetical thing whose existence is inferred from apparently indirect evidence, existing within a virtual reality.

Virtual Reality: An artifactual environment, image, process or scenario conjured and experienced through sensory or neuronal stimuli and in which one's actions partially determine what happens in the environment.


[b]B. Relevant definitions of Earth life: [/b]

Earth Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

Earth organism: a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.

Gene: a primal Earth's organism. (1st, base, stratum organism)

Genome: a multigenes organism consisting of a cooperative commune of its member genes. (2nd stratum organism)

Cellular organisms: mono- or multi-celled earth organisms. (3rd stratum organism)


[b]C. Relevant comprehensions of culture[/b]

- The integrated pattern of human knowledge, belief, and behavior that depends upon the capacity for learning and transmitting knowledge to succeeding generations.

- The customary beliefs, social forms, set of shared attitudes, values, goals, and practices
and material traits of a group, and the characteristic features of its everyday existence.

- The totality of ways of the organisms' dealing with (reaction to, manipulation of, exploitation of) its environment. A biological entity selected for survival of the genome as means of extending its exploitation capabilities of the out-of-cell circumstances, consequent to the earlier evolution and selection of the genome's organ, its outermost cell membrane, for controlling the inside-of-cell genes'-commune environmental circumstances.

- The ubiqitous biological entity that drives Earth life evolution by imprinting genetics, by continuously modifying genes' expressions.


[b]D. Comprehension of "spiritual matters"[/b]

"Spiritual matters" are virtual reality affairs. They are feasible only for living organisms that have a culture, i.e. that have a pattern of sensings and reactions to the sensings. Genes, and therefore also genomes, are organisms and display virtual reality phenomena, therefore also multicelled organisms,including humans, display such "spiritual" phenomena.


[b]E. Virtual reality and the 21st century world economy collapse[/b]

The 21st century world economy collapse is a collapse of a culture, of the 20th century technology culture, of its values and attitudes and ethics and morals. The world's population is still (Feb 2009) clinging desperately to the collapsed concepts and expectations and makes a huge painful effort to revive the collapsed culture instead of to steadfastly modify it. It is sadly and exasperatingly obvious that the economy collapsed due to adherance to absurd virtual reality concepts and expectations, and that the only hope to survive and overcome the collapse is to understand its nature and to plan and embark on a course to a new, science-based, more rational, virtual reality culture.


Dov Henis
(Comments From The 22nd Century)

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407 ]]> http://www.the-scientist.com/community/posts/preList/122/1613.page http://www.the-scientist.com/community/posts/preList/122/1613.page GMT sharbani_ranjan@yahoo.co.in]]> http://www.the-scientist.com/community/posts/preList/122/1625.page http://www.the-scientist.com/community/posts/preList/122/1625.page GMT

[b]A. Re 21st century culture-economy collapse [/b]

http://www.the-scientist.com/community/posts/list/120/122.page#1625

[quote]"What Dov Henis writes I tend to disagree. Common human culture can not be enforced. Culture is like evolution. It happens over spans of time by selection. The process is slow. It is by nature assimilative. We tend to gloss over differences and drive roughshod. This is a mistake. Culture is popular knowledge assimilation. You try to speed up the process and the elastic snaps. Cultures wherever are to be respected and knowledge reverse engineered to appreciate the foundations of the cultures." Sharbani Ranjan Kundu[/quote]


[b]B. Survival mandates rational steering of cultural evolution[/b]

What Sharbani writes I tend to disagree. Nowadays human culture can be "enforced", steered. Until few hundreds of years ago specific human cultural phenotypes used to evolve over lengths of time by "natural selection", which, BTW, is also "enforced" by circumstances and environments. But in recent human history "selection" has been more and more "enforced" by some on other human cultural phenotypes, like in post WWII Japan and Germany.

Throughout life's evolution "culture" used to evolve over spans of time in response to "enforcement" by a variety of factors including circumstances, invading genes or other organisms, or invading different cultural phenotypes. However, in recent human history humans have been playing god more and more, interfering with natural "natural selection", accelerating cultural evolutions of many organisms, including humans'.

If you do not speed up the "enforced" evolutionary process, the elastic snaps. You allow and promote evolution of destructive catastrophes. Wise and prudent cultural phenotypes would elect and promote rational self re-education re-orientation.

However, human cultural phenotypes, whatever and wherever they are, that threaten the evolution of welfaring humanity, should not be respected and "understood". They should be assessed rationally and "engineered" to evolve without a threat to other human cultural phenotypes. The interference criterion should be the extent of factual and potential threat.


Suggesting,

Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1649.page http://www.the-scientist.com/community/posts/preList/122/1649.page GMT [b]Recapitulation of few earlier posts[/b]


[i]The evidence is obvious all around us, as we live and sleep,
just stop running and reflect a while...[/i]

[b]A. Again and again, comprehension of the nature of Earth life: [/b]

[i]Earth life:[/i] 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

[i]Earth organism: [/i]a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by maintenance of genes.

[i]Gene:[/i] a primal Earth's organism. (1st-, base-, stratum organism)

[i]Genome:[/i] a multigenes organism consisting of a cooperative commune of its member genes. (2nd stratum organism)

[i]Cellular organisms:[/i] mono- or multi-celled earth organisms. (3rd stratum organism)


[b]B. Again and again, the nature, origin, function and purpose of life [/b]

[i]Nature of Earth life:[/i] a replicating construction temporarily constraining and maintaining energy.

[i]Origin of Earth life:[/i] serendipitous energy-induced formation of Earth's primal organisms, individual independent genes.

[i]Nature of Earth's organisms:[/i] temporary self-replicable constrained-energy genetic systems that support and maintain Earth's biosphere by maintenance of genes.

[i]Function of Earth life:[/i] uphold and maintain as much constrained energy as possible by upholding and maintaining Earth's biosphere. (Probably one of several constrained energy forms, including black holes).

[i]The purpose of OUR life[/i] and its promotion is ours to choose and set. It derives solely from our cognition, which is a biological entity.

The biggest hindrance of scientific and of technological progress in comprehension and exploitation of biology is the avoidance to accept-regard genes and genomes as organisms. Equally hindering is the avoidance to accept and to explicitly and clearly define genes as The Primal Base Cardinal Earth Life Organisms, the organisms that have been evolving into all other Earth organisms.

This avoidance, fraught with implications about human conception of the nature of life, is the biggest hindrance of human culture, of human existential and social progress.


[b]C. Sleep, most obvious evidence of genes' life and their origin[/b]

Sleep made simple. Why do organisms sleep?

Sleep is an inherent Earthlife trait. Organisms sleep because their genes-genomes sleep. And for genes, sleep is inborn because genes were the first organisms evolved on Earth and they came into being, born, through the sun's radiation energy absorbed by RNA-type oligomers, and the newborn genes were active ONLY when exposed to sunlight, which was then - prior to bio metabolic energy production - their only usable energy. Thus sleep is an inherent Earthlife trait.


[b]D. Chirality, most obvious evidence of genes' primal, base, status in life's evolution[/b]

Darwinian evolution started at life's day one, with the genesis of the first organisms, the replicating oligomers, pre-archaea genes. It started under yet-unknown energetic conditions, by a serendipitous accident, with oligomeric (RNA?) conformations, in a soup containing all their essential molecular progenitors. These conformations happened to absorb the amounts of energy enabling their polymerization to lengths precipitated as determined by the nature and conditions of the soup.

The sugars and the nitrogen-based compounds that, together with the phosphates, are the components of the genes organisms, are chiral. There probably is an energetic advantage in homochirality and chiral homogeneity for the self-replication of biopolymers.

This serendipitous accident set up a matrix-field of energy with a potential extended between its source, sun's radiation, and the precipitating organisms. This was the genesis of the ongoing formation and maintenance of Earth's biosphere.

And since thus the biosphere started it could only evolve in more favorable energetic directions and towards stabler components. Survival. Chiral organism survival. After all this was already into the process of life's evolution...


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1689.page http://www.the-scientist.com/community/posts/preList/122/1689.page GMT [b]( recapitulation )[/b]


[b]A. Aging, lifetime and age[/b]

Aging = to become old, show the effects or the characteristics of increasing age, the increasing liferime. The effects and characteristics of not only the totality of the system, but also of each and every component, and of components of the components of the system. The system is the totality of the components.

lifetime = the duration of the existence of a living being, an organism, or an inanimate thing, a material, star or subatomic particle.

age = the length of an existence extending from its beginning to any given time.


[b]B. More and more research works related to old age are published in scientific periodicals[/b]

The lengthening list of work-accounts comprises a wide array of subjects apparently related to old age, including:

- A variety of constitutional impairments,
- a variety of impaired biological processes,
- a variety of impaired genetic materials and expressions,
- a great variety of suggested things to consume or do or avoid for alleviating the symptoms,
- and a great variety of anti-aging suggestions.


[b]C. Some examples of statements:[/b]

- A little stress may keep cells youthful.
- Intestinal stem cells, that replenish the lining, go awry in elderly flies, similar to what
happens in certain human stem cell populations.
- Yeast, worms and people may age by similar mechanisms.
- Nearly all organisms experience aging.
- In aging muscles and neurological problems, energy greedy organs, there are mitochondria
dysfunctions.
- Age-related growing 'leakiness' in cell nucleus membrane may contribute to aging and even
to diseases such as Parkinson's and Alzheimer's.
- Age-Related Hearing Impairment, presbycusis, is a complex elderlies disease caused by
overexpression of glutamate due to interaction between environmental and genetic factors.


[b]D. Right they are: "Nearly all organisms experience aging". But why "nearly"?[/b]

Why don't "scientists" accept the obvious fact that genes are organisms and "experience aging", too?

Not only yeast, worms and people. Also genes and the interdependent-genes-communes, genomes. Theye are both organisms. They are alive. It is their "lifehood" that makes us and all life forms "alive".

By plain common sense - my favorite scientific approach - they should also be "experiencing aging"...


[b]E. The aging of genes contributes to organisms aging[/b]

Since a genome is a cooperative commune of interdependent genes, many of its member genes "modulate its aging" to various extents at various time-rates depending on circumstances and environment and on their individual composition and functioning history. Various things happen to them or affect them and impair their functionalities.

In my plain commonsensical mind "interaction between environmental and genetic factors" is a description of organism's "aging". And in my boy's-like view of the emperor's new clothes organism's aging comprises aging of its genes-genome, and genes and genomes age as we age, and we age also as a result of the aging of our genes and genomes...


[b]F. Finally, re "Theories about human cellular aging supported by new research" [/b]

http://www.eurekalert.org/pub_releases/2008-12/asfc-bta111908.php

"Research presented at American Society for Cell Biology conference:
Aging yeast cells accumulate damage over time, but they do so by following a pattern laid down earlier in their life by diet as well as the genes that control metabolism and the dynamics of cell structures such as mitochondria, the power plants of cells."

Cellular Aging? What is Cellular Aging?

Complexly instrumented future spacestations accumulate damage over time, and their residents, too, age and accumulate damage over time. Yes, the functionality of the stations' residents and of their intruments and equipment is impaired with age. Wonder why?

The reason for the impairment with age of the highly active instrumented-equipped stations and of their resident crew is that they "follow a pattern laid down earlier in their life by diet as well as by the residents who control metabolism and the dynamics of the stations' structures such as mitochondria, their power plants."


[b]G. Enough. Cells just house organisms. The resident genes-genomes are THE organisms.[/b]

About time that "scientists" refresh conceptions and comprehensions and attitudes and research plannings and peer-reviewings. Let their science evolve...


Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407 ]]> http://www.the-scientist.com/community/posts/preList/122/1692.page http://www.the-scientist.com/community/posts/preList/122/1692.page GMT [b]Listen listen, The Wheel Is Reinvented!
Plant's Genome Found Linked With Plant's Culture![/b]


[b]A.[/b] listen, listen
the cat's pissin
where, where?
under the chair
hurry hurry bring the plate
never mind, it's too late...


[b]B. New from "Ecological nitrogen-limitation shapes the DNA composition of plant genomes"[/b]
http://mbe.oxfordjournals.org/cgi/content/abstract/msp038

- "The influence of ecological limitations on the composition of eukaryotic genomes is still unclear"

- "These findings indicate a fundamental role of nitrogen limitation in the evolution of plant genomes, and they link the genomes with the ecosystem context within which biota evolve."


[b]C. "Seed of Human-Chimp Genomes Diversity"[/b]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=409
Nov 2005, Dov, in biologicalEvolution forum.

Biological Evolution's Seeds of Diversity, Human and Chimpanzee/Bonobo Genomes

[u][i]Chapter One,[/i][/u] In which some wonder what made us human.

Three recent quotations from Science, representative of many other recent similar statements in various scientific publications:

1) "Understanding the genetic basis of how genotype generates phenotype will require increasing the accuracy and completeness of the currently available chimpanzee genome sequence, as well as sequencing other primate genomes."

2)"Can we now provide a DNA-based answer to the fascinating and fundamental question, "What makes us human?" Not at all! Comparison of the human and chimpanzee genomes has not yet offered any major insights into the genetic elements that underlie bipedal locomotion, big brain, linguistic abilities, elaborated abstract thought, or any other unique aspect of the human phenome."

3)"What makes us human? This question may be answered by comparison of human and chimpanzee genomes and phenomes, and ultimately those of other primates. To this end, we need to understand how genotype generates phenotype, and how this process is influenced by the physical, biological, and cultural environment."

[u][i]Chapter Two,[/i][/u] In which is explained plainly and succinctly the obvious route by which we evolved,

i.e. that genotype has not generated phenotype, that we evolved from our genotype via a group of feedback loops. From Science, Vol 308, Issue 5728, 1563-1565 , 10 June 2005, Immunology: Opposites Attract in Differentiating T Cells, Mark Bix, Sunhwa Kim,Anjana Rao:

"During differentiation, precursor cells with progressively narrowed potential give rise to progeny cells that adopt one of two (or more) divergent cell fates. This choice is influenced by intricate regulatory networks acting at multiple levels. Early in differentiation, precursor cells show low-level activation of all progeny genetic programs. Bias toward a given lineage comes from environmental inputs that activate powerful positive- and negative- feedback loops, which work in concert to impose selective gene expression patterns".

[u][i]Chapter Three, [/i][/u] In which we explain the revolutionary evolved uniqueness of the human ape's phenotype:

The 6My-old revolutionary life evolution was initiated by our forefathers who adapted from life in semi- or tropical forest circumstances to life on plains. As changed living posture and circumstances led to modified perceptive/adaptive capabilities and eventually to language communication humans have gradually replaced adaptation to changed circumstances with self-evolving cultures/civilizations for control and modification of much of their circumstances. This is essentially similar to early life's celling evolution, but with culture functioning for humans for change/control of circumstances in lieu of RNA and protein toolings that function for the in-cell genomes for adapting their cell's physiology to changing circumstances.

[u][i]Chapter Four,[/i][/u] In which appears, may be, genetic evidence/demonstration of the workings of human cultural evolution.

(a) From Science, 2 Sept 2005: "Page's team compared human and chimp Ys to see whether either lineage has lost functional genes since they split.

The researchers found that the chimp had indeed suffered the slings and arrows of evolutionary fortune. Of the 16 functional genes in this part of the human Y, chimps had lost the function of five due to mutations. In contrast, humans had all 11 functional genes also seen on the chimp Y. "The human Y chromosome hasn't lost a gene in 6 million years," says Page. "It seems like the demise of the hypothesis of the demise of the Y," says geneticist Andrew Clark of Cornell University in Ithaca, New York."

(b) But look at this: From Science, Vol 309, 16 Sept 2005, Evolving Sequence and Expression:"An analysis of the evolution of both gene sequences and expression patterns in humans and chimpanzees...shows that...surprisingly, genes expressed in the brain have changed more on the human lineage than on the chimpanzee lineage, not only in terms of gene expression but also in terms of amino acid sequences".

Surprisingly...???

[u][i]Chapter Five [/i][/u] and conclusion, In which I suggest that detailed study of other creatures that, like humans, underwent radical change of living circumstances, for example ocean-dwelling mammals, might bring to light unique evolutionary processes and features of evolutionary implications similar to those of humans. end.DH.


[b]D. How astonishingly wondrous is the familiarity of nowadays researchers with years-old published scientific comprehensions [/b]

From "Factors Involved In Extended Historical Darwinism"
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=409

- Earth Life Is A Real Virtual Affair; it pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere .

- Genes are organisms, interdependent members of genes communes, genomes, all continuously undergoing evolution directed towards survival as long as possible, for maintaining Earth's biosphere as long as possible.

- Culture is a ubiquitous biological entity and is the major effector of genetic evolution, of capabilities and attributes selected for survival.

- The major course of natural selection is NOT by random mutations followed by survival, but via interdependent, interactive and interenhencing selection of biased replication routes by genes at their alternative-splicing-steps junctions, effected by the cultural feedback of the 3rd stratum multicells organism or monocells community to their prime stratum genes via their 2nd stratum genome organisms.

- Evolution of life is but a minute component of the evolution of the universe. Cosmic evolution is the evolution of energy. Life, and all objects and processes and natural laws in the universe, are - since none in exsistence at singularity - products of evolution and are continuously further evolving. Everything in the cosmos is fractal, rehappens on many scales, and is continuously evolving. Each and every system in the universe continuously evolves within the total universal evolution and all the systems' evolutions are intertwined and within it life's evolution is the evolution of genes-genomes, continuously evolving in a losing attempt to survive, to maintain - as long as possible - pockets of constrained energy that would otherwise, and anyhow eventually, expand and dilute with the whole mass and energy of the cosmos...

Dov Henis

PS: Puzzled why even Darwinians do not comprehend that Darwinism starts all the way back with Life's day one, with the pre-archaea not-yet-genomed-celled genes...


Exasperated,

Dov Henis
(Comments From 22nd Century)]]> http://www.the-scientist.com/community/posts/preList/122/1707.page http://www.the-scientist.com/community/posts/preList/122/1707.page GMT

[b]A. Cells do, cells get.[/b]

"Cells get two chances, not just one, to fix their mistakes"...?
http://www.physorg.com/news156087023.html

- Cells do not get any chance nor do they do anything. Cells are NOT organisms. A cell is the housing, the space ship, of its resident genome, the cooperative commune of its interdependent genes membership. Cell membranes are organs, plain and simple, organs evolved by genome to protect and maintain their living milieu. About time for the myopic 21st century science to realize this and to correct its concepts, instead of mindlessly repeating its mantras...


[b]B. "Missing piece of plant clock found", about "the underlying biochemical mechanisms that control plant clocks".[/b]
http://www.physorg.com/news156087384.html

- A coming research report will re-affirm, in sophisticated sciencelingo, that the rooster indeed brings on sunrise, or that Gazania flowers switch the sun on and off. There is no "biochemical mechanisms that control bio clocks". Bio-clocks are products of the innate active-sleep pattern of genes and genomes, parents of all Earth's Life, since in their days of genesis and early evolution direct sunlight was the only source of energy in pre-metabolism Earth life. Melatonin and some proteins are dark-and-light que signals evolved by later monocellular communities for timing intercells processes when intracell processes are at rest.


[b]C. "Culture skews human evolution"[/b]
http://www.physorg.com/news156100530.html

"...(there is a) cultural buffering of evolution’s harsh rule of “survival of the fittest” that may be leading to the “dysevolution” of Homo sapiens.

- This is a confused concept-comprehension of evolution. Genetic evolution does not occur in accordance with an evolution rule-law, and it is not a result of survival of the fittest. Genetic evolution, i.e. changes in expressions of genes, are mostly not random and are not the source of evolution but the consequences of cultural evolution, i.e. of evolved survival patterns. First evolves the culture of the organism, i.e. its pattern of assessing of/reaction to its circumstances, then the organism's cultural pattern impacts the genes-genome and consequently the genes change their expressions.


Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201]]> http://www.the-scientist.com/community/posts/preList/122/1722.page http://www.the-scientist.com/community/posts/preList/122/1722.page GMT
[b]Evolution:
Genes to Genomes to Monocellular to Multicellular Organisms,
Direct Sunlight to Metabolic Energy, Too,
Triptophan to Serotinin to Melatonin to Neural System.[/b]

[b]A. Triptophan to Serotinin to Melatonin[/b]

Melatonin is a hormone secreted by the human pineal gland during night-time darkness. It is now marketed in the US as a nutritional supplement. The hormone is an indoleamine compound derived from the essential amino acid L-tryptophan, with serotonin as an intermediate precursor.

Tryptophan is one of eight essential amino acids, not produced by the body but coming from the diet. The additional fourteen amino acids are produced metabolically.

In the brain, tryptophan converts to serotonin, the neuro-transmitter. Tryptophan is the only source for serotonin in the brain. Insufficient L-tryptophan in the diet is a cause of many severe biological malfunctions.

Some serotonin is converted in the pineal gland to melatonin, the hormone involved in intercell processes during sleep time.


[b]B. Sunlight to Metabolic Energy[/b]

Bio-clocks are products of the innate sun-dictated active-inactive pattern of genes and genomes, parents of Earth's life. During life genesis and its early evolution direct sunlight was the only source of their usable energy. This situation persistrd well into the evolution of the early monocellular organisms, and both genes and genomes display, therefore, innate "inactive-sleep" phenomena.

The incorporation of mitochondria with some cells innitiated the metabolic bio production of bio usable energy and furnished the evolving monocellular organisms with new, additional, flexibly available local energy. This development opened up a variety of courses of evolutions of cultures of monocells communities.


[b]C. Individual Monocells to Cooperative Monocells-Communities[/b]

As individual independent genes aggregated to cooperative genes communes, genomes, so individual monocells aggregated cooperatively into monocellular communities.

From "Life Is A Cooperative Affair" (Sept 2005)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=168

"Life has always been and still is a fractal affair, repetition of phenomena on ever more complex scale. It cannot be otherwise; it evolves. And surviving-proliferating life has always been a cooperative affair since cooperation is most successful for overall survival/proliferation."

Cooperation requires all sorts of interactions, including maintenance, protection and foraging for food-energy. Organisms' interactions are "cultures". Cultures require "cultural energy". Melatonin and some proteins are dark-and-light que signals evolved by the monocells communities for timing intercells processes when the intracell processes are at "sleep-inactive" state. Melatonin is a derivative of serotonin a derivative of triptophan, and proteins are genes' toolings, energy-dependent metabolism products.


[b]D. Monocellular to Multicellular Organisms, Monocells Culture to Neural System[/b]

Now we can appreciate the fractal nature of life's evolution. It is ever-continuous ever-enhanced ever-complexed cooperation. Now we can understand why, and grosso modo how, all the organs and processes and signals found in the multicelled organisms have their origins in the monocells communities. And this includes the functions of serotonin and melatonin and, yes, the evolution of neural cells and the neural system with their intricate outer-membrane shapes and functionings and with their high energy consumption requirements.


Now, circa four billion years after initial genesis-evolution with direct sun's energy followed with evolution with also indirect, bio, sun's energy, some of Earth life, we humans, find ouselves short of energy and in need of exploiting again more, and more directly, our sun's energy...


Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1726.page http://www.the-scientist.com/community/posts/preList/122/1726.page GMT

[quote]nullTS1019153][u][b]Life Is Simpler Than They Tell Us[/b][/u]

[b]Evolution:
Genes to Genomes to Monocellular to Multicellular Organisms,
Direct Sunlight to Metabolic Energy, Too,
Triptophan to Serotinin to Melatonin to Neural System.[/b][/quote]
Then look at this:

Live Wires
http://www.sciencenews.org/view/feature/id/41637/title/Live_Wires
Cells reach out and touch each other with tunneling nanotubes


Urging,

Dov Henis

]]> http://www.the-scientist.com/community/posts/preList/122/1757.page http://www.the-scientist.com/community/posts/preList/122/1757.page GMT [b]Complete Functional Gene Transfer[/b]


[b]A. From "Aphids support symbionts with borrowed DNA"[/b]
http://www.sciencenews.org/view/generic/id/41539/title/Aphids_support_symbionts_with__borrowed_DNA

Aphids borrowed at least two genes from bacterial buddies, and those genes now support another bacterium that lives in the insect. Those two genes are active in specialized cells called bacteriomes. The insects provide a home for the bacterium and the bacterium provides essential nutrients for the insects’ growth.

While scientists have known that bacteria can transfer DNA to their hosts, most of the transferred DNA doesn’t contain genes. The new discovery is the first evidence of the transfer of functional genes from bacteria to host.

Aphids and Buchnera have lived together for more than 100 million years. They have become so interdependent that the bacterium’s genome is stripped down to the point that it no longer contains many of the genes the bacterium needs to sustain itself. One of the genes Buchnera lacks is ldcA, which encodes a molecule that helps recycle a component of the bacterium’s cell wall. Atsushi Nakabachi and Naruo Nikoh discovered that aphids contain an ldcA gene similar to one found in another bacteria, Wolbachia. The aphids make the recycling molecule in cells where Buchnera live, suggesting that the aphids are providing the bacterium with a way to build and repair cell walls. The transfer most likely happened in an ancestor of several different aphid species, one that was colonized perhaps by both Wolbachia and Buchnera.

Pea aphids also contain another gene that came probably from bacteria called Bradyrhizobium.

Scientists have previously suspected that gene transfers happen frequently between multicellular organisms and the bacteria they live closely with, but they thought that those transfers were dead ends, says John Archibald. Unless the DNA makes its way into the germ line, the tissues that will produce eggs and sperm, the transferred DNA won’t be passed along to subsequent generations of hosts. It isn’t yet clear how Wolbachia managed to insert their genes into the aphid genome in a heritable way, Archibald says.

These [findings] indicate that organisms including animals are much more flexible than expected, and can be more easily fused with other organisms,” Nakabachi says.


[b]B. Some notes on the interesting findings [/b]

(1) I reckon that the above "the aphids make the recycling molecule" means that "the aphid's ldcA gene is expressed in the bacteriomes".

(2) The abstract starts with "Aphids borrowed the genes". We observe, apparently, a ubiquitous transaction between organisms.

It is unreasonable that an X genome, a multigenes organism of creature X, and a gene of a Y creature, an organism that is an obligate member of Y's genome community, would "incorporate" with each other just for fun or due to curiosity or by accident. A successful horizontal gene transfer between two organisms occurs rationally due to either the interests of both organisms or to the interest of the gene donor, an invader.

(3) The above "organisms including animals" refers, I reckon, to monocelled bacteria as organism and to multicelled aphids as animals.

I'm not tired of repeating over and over again my suggested conception of Earth life as a construct of three strata of organisms, genes, multigenes genomes and celled (mono- and multi-), and I'm confident that this concept will be eventually adopted by science and by the public, with profound implications for human culture.


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1833.page http://www.the-scientist.com/community/posts/preList/122/1833.page GMT [b]And Are Earth's Primal Organisms[/b]
[i](a recapitulation)[/i]

[b]A. Pushing back an oxygen-rich atmosphere date[/b]
http://www.sciencenews.org/view/generic/id/41755/title/Pushing_back_an_oxygen-rich_atmosphere
Hematite crystals in Australian rocks hint that Earth’s atmosphere was oxygenated earlier than previously thought.

There’s evidence of eukaryotic life, i.e. monocellular organisms with DNA sequestered in a protective nucleus, from roughly 1.9 billion years ago. Multicellular animals appear on the scene much later.

Large quantities of oxide minerals in rocks around the world indicate that the atmosphere had at least small amounts of oxygen by 2.2 billion years ago. The presence of certain biomarkers in Australian rocks has been hailed as evidence that oxygen-making organisms had evolved by 2.7 billion years ago, but recent studies have cast some doubt on that earlier date.

Now, analyses of rocks laid down 3.46 billion years ago in what is now Australia push back the oxygen era even further, Hiroshi Ohmoto, a geochemist at Pennsylvania State University in University Park, and his colleagues contend online March 15 in Nature Geoscience.


[b]B. Earliest single-celled organisms[/b]

(Forwarded) If the 4.6 billion Earth years are compressed into a single year: the Precambrian Era, evolution of first life forms, extends from January 1 to mid-November; the Paleozoic Era, evolution of invertebrates and primitive fishes, extends through the rest of November and part of December, and the Mesozoic, era of dinosaurs, takes up most of the remainder of December. Our time, the Quaternary, would occupy only the last four hours on New Year's Eve.

For most of Earth's history, there were only single-celled organisms. Fossilised single-celled micro-organisms have been found in rocks 3·5 billion years old.

By 2.4 Ga (gigaannum = 10^9 years) the ratio of stable isotopes of carbon, iron and sulfur shows the action of living things on inorganic minerals and sediments and molecular biomarkers indicate photosynthesis, demonstrating that life on Earth was widespread by then.


[b]C. Revised fixations that cells were the earliest Earth-life's organisms, and that tie life's genesis with organic bio-metabolism [/b]

These fixations dictate that Earth's earliest organisms were fueled by netabolically self-generated energy.

But cells were NOT the earliest Earth-life's organisms. [i]Genes, Not Cells, Were Earth's First Organisms, And Are Earth's Primal Organisms. [/i]
Cells are no more organisms than future manned spaceships would be organisms. The innner and outermost cell membranes are multi-functional organs evolved and produced by the organisms that reside within the outermost membrane, as would be the spaceship's inner and outermost skins-walls produced by their residents, even if the membranes are organic whereas the skins-walls are not. And undoubtedly the capabilities of multi-functional spaceship skins-walls would be far below those of cell's membranes.

The primal genes came into being, phased from polymers into replicating beings, organisms, by absorbed sun energy, and proceeded to carry on their life during daylight times, fueled solely by sun energy, and this most probably was the state of life affair until sometime earlier than 3.5 Ga, which is when fossilised single-celled micro-organisms have been found in rocks.


[b]D. It is thus rationally possible to de-couple life's genesis and onset of bio-metabolism,[/b]

and to update the comprehension of the nature of Earth life per
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578


Dov Henis
(Comments From The 22nd Century)
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
or
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1850.page http://www.the-scientist.com/community/posts/preList/122/1850.page GMT [b]FW: 2 Cultures in New York City[/b]


On May 9, 2009 "visionaries, scientists, authors, and the media will join together to explore the persistence of the sciense-public cultures gap and how it may be overcome":

http://www.nyas.org/snc/twocultures/index.asp

I hope that I'm wrong.

In my sad opinion this "unique and important event" will, most probably, result only with louder racing engine noise as the gas pedal is pushed further down in the science vehicle jacked-up-from-the-ground in the 21st-century technology culture.

http://www.articlesbase.com/science-articles/economy-collapse-cure-delusion-799133.html


Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/1870.page http://www.the-scientist.com/community/posts/preList/122/1870.page GMT

[b]A. Vaccine could protect against virus that causes birth defects[/b]

http://www.sciencenews.org/view/generic/id/41874/title/Vaccine_could_protect_against_virus_that_causes_birth_defects

An experimental vaccine is shown effective half the time it's administered in stopping cytomegalovirus infection in women in their child-bearing years.

No vaccine currently exists for cytomegalovirus, which can cause birth defects when it infects a pregnant woman. Because of this risk, vaccine researchers have targeted the virus for decades — without any clear benefit until now.

This is the first vaccine that really shows prevention from infection with cytomegalovirus.


[b]B. Efficiency rate might differ with hour-of-timing of administration[/b]

http://www.articlesbase.com/science-articles/life-is-simpler-than-they-tell-us-817144.html

I suggest that the efficiency rate of the vaccine might differ depending on the hour of day at which it is administered. This since the genome-genes are inactive mostly circa 2AM and the levels of serotonin-melatonin are highest then, signalling a call for intercell maintenance time.


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201]]> http://www.the-scientist.com/community/posts/preList/122/1874.page http://www.the-scientist.com/community/posts/preList/122/1874.page GMT

[b]A. "Tired brain defaults differently"[/b]
http://www.sciencenews.org/view/generic/id/42054/title/Tired_brain_defaults_differently

- "Sleep deprivation may cause the brain to switch to default mode when it should be paying attention."
- "Sleep deprivation affects the brain's network"
- "Sleep is essential for the proper functioning of the brain's network"


[b]B. "Life Is Simpler Than They Tell Us" [/b]
http://www.the-scientist.com/community/posts/list/120/122.page#1726

And [b]"2009 Passe Mantras"[/b]
http://www.the-scientist.com/community/posts/list/120/122.page#1722

There is no biochemical mechanisms that control bio clocks. Bio-clocks are products of the innate active-sleep pattern of genes and genomes, parents of all Earth's Life, since in their days of genesis and early evolution direct sunlight was the ONLY source of energy in pre-bio-metabolism Earth life. Melatonin and some proteins are dark-and-light que signals evolved by monocellular communities for timing communal intercells maintenance processes during the daily genes' inactive time, when intracell processes are at rest.

Even though genes and genomes are both organisms, it is not clear if sleep deprivation "tires" them and thus "tires the brain". The nature of the tiredness is not clear. However, it is most probable that sleep deprivation interferes with the brain's intercells maintenance processes, thus mal-effecting proper normal functioning of the brain's network.


Suggesting,

Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201]]> http://www.the-scientist.com/community/posts/preList/122/1904.page http://www.the-scientist.com/community/posts/preList/122/1904.page GMT

[b]A. "Chimps ambidextrous when digging wells"[/b]
http://www.sciencenews.org/view/generic/id/42475/title/Chimps_ambidextrous_when_digging_wells
A survey of water-collection holes dug on the banks of an African river by wild chimpanzees indicates that, unlike people, these apes don’t have a preference for using either the right or left hand on manual tasks.


[b]B. Human dexterity preference became genetic by compulsions of changing human culture[/b]

[i]"Human brain contralaterallization" [/i]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=153

A note I e-mailed July 18, 2005 to C Walsh, Harvard, re his "Asymmetry in Human Left/Right Cerebral Cortex", Science, Vol 308, Issue 5729, 1794-1798, 17 June 2005.

A) You write: "The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries.

B) The expression "asymmetry has a molecular basis" sounds strange. The aspects of the asymmetry include, of course, ALSO genes' expressions, the total asymmetry being the product of specific evolution of the human cerebral cortex.

C) In July 1997 I wrote the following "conjectural scenario":

" Humans' uniqueness on Earth was initiated by a stimulus in a zone in the brain of some of them when challenged by needs for new manipulations, and for new capabilities of analysis and assessments of wider vistas open to them when changing posture to erect due to change of environment from forests to plains. The new demands employed existing brain cells in one half of their brain, overtaxed its capabilities and led to compensation by overworking the symmetrically located cells in the second half of the split brain and this in turn led again to compensation in the first half thus causing contralaterallization that is still evolving now".

D) I suggest that the probability of a similar asymmetry might be sought in ocean mammals, having undergone a radical intensive change of living circumstance and mode, like our ancestral primates.

Respectfully,
DH

Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1945.page http://www.the-scientist.com/community/posts/preList/122/1945.page GMT

"Hobbit brain small, but organized for complex intelligence"
http://www.sciencenews.org/view/generic/id/42469/title/Hobbit_brain_small%2C_but_organized_for_complex_intelligence
"Evolution may have endowed a controversial species with small but humanlike brains equipped to support advanced thinking."


[i]Evolution Does Not Endow Anyone With Anything.
It Is One's Culture That Endows Its Genetics.[/i]

This is what evolution is all about...


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1965.page http://www.the-scientist.com/community/posts/preList/122/1965.page GMT

[b]A.[/b] "Sleep may clear the decks for next day’s learning"
http://www.sciencenews.org/view/generic/id/42456/title/Sleep_may_clear_the_decks_for_next_day%E2%80%99s_learning
Two separate studies suggest that sleep reduces connections between neurons in fruit flies’ brains.

[b]B.[/b] "Missing piece of plant clock found", about "the underlying biochemical mechanisms that control plant clocks". 2009 Passe Mantra.
http://www.physorg.com/news156087384.html

[b]C. [i]No End Of Passe Sleep Mantra[/i][/b]

Future research reports will re-affirm, in sophisticated sciencelingo, that the rooster indeed brings on sunrise, or that Gazania flowers switch the sun on and off.

It's about time to understand the origin and function of sleep. There is no "biochemical mechanisms that control bio-clocks". Bio-clocks are products of the innate active-sleep pattern of genes and genomes, parents of all Earth's Life, since in their days of genesis and early evolution direct sunlight was the only source of energy in pre-metabolism Earth life. Melatonin and some proteins are dark-and-light que signals evolved by later monocellular communities, pre-multicellular organisms, for timing intercells clean-up and maintenance processes when intracell genes-genome processes are inactive.


Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201]]> http://www.the-scientist.com/community/posts/preList/122/1966.page http://www.the-scientist.com/community/posts/preList/122/1966.page GMT
Cause Of Broadband Deployment Is Not Yet Determined, But
The Cure Of The World Economy Crash Is Imminent,
[u]Now How Will The Post-Crash Economy Affect Innovation?[/b][/u]

FW: Tech Policy Summit in Silicon Valley
Tech Policy Summit, May 11-13,2009 - Silicon Valley


"Technology is rapidly changing every aspect of our lives, but often our policy thinking is stuck in old habits of [i]a pre-tech past[/i]. The Obama administration is making some moves to adapt to this [i]new "World 2.0," but are they enough? And what about Congress and state policymakers? How will the post-crash economy affect innovation?[/i] To explore these questions, ScienceDebate.Org is partnering with Tech Policy Central to cosponsor this year's Tech Policy Summit in Silicon Valley.

Hosted by BusinessWeek columnist Steve Wildstrom, the 2009 Summit will focus on strategies for [i] accelerating innovation and economic growth [/i]with an [i] in-depth look at the latest developments in broadband deployment,[/i] smart grid technologies, digital privacy, spectrum access, and more.

Members of the Science Debate founding team will be participating in a special roundtable discussion about the importance of elevating science in public policy, along with Dan Byers of the U.S. House Science and Technology Committee and Marc Stanley of the National Institute of Standards and Technology's Technology Innovation Program.

Tech Policy Summit offers you a chance to network with an exclusive group of thought leaders while gaining a better understanding of how the innovation policies of the Obama administration and Congress stand to impact the tech sector. Featuring over 60 speakers from industry, government, NPOs and academia.

Registration is only $295 when you sign up with the 4SCIENCE Discount Code, and a portion of your fees will be donated to ScienceDebate.Org."


Fw'ed by
Dov Henis
http://www.articlesbase.com/science-articles/economy-collapse-cure-delusion-799133.html
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=419]]> http://www.the-scientist.com/community/posts/preList/122/1980.page http://www.the-scientist.com/community/posts/preList/122/1980.page GMT [b]PS To
On Humans,And Other Materials, Evolutions
And On The Sad State Of Life,And Other, Sciences In 2009[/b]

[b]A. Re "Stanford researchers show adaptation plays a significant role in human evolution"[/b]
http://www.eurekalert.org/pub_releases/2009-01/su-srs011409.php


1) "For years researchers have puzzled over whether adaptation plays a major role in human evolution or whether most changes are due to neutral, random selection of genes and traits."

- I have been presenting evidence for years that adaptation, i.e. culture, is the driver of evolution of all life including human and, yes, of all other materials, and that genetic evolution is generally biased, not random.

2) "Geneticists at Stanford now...show adaptation, the process by which organisms change to better fit their environment, is indeed a large part of human genomic evolution."

- Shortly after retiring from industrial consulting (1956 - 1998) I started investigating the state of comprehension of the nature of life and of its evolution and I published evidence and conclusion that culture is the driver of all genomic evolution.

3) "Others have looked for the signal of widespread adaptation and couldn't find it...now...we were able to detect the adaptation signatures quite clearly"

- I found the evidence many years ago and presented it clearly in my postings.

4) "All genetic mutations start out random, but those that are beneficial to an organism's success in their environment are directly selected for and quickly perpetuate throughout the population, providing a uniform, traceable signature."

- NO NO NO. The drive of evolution is NOT RANDOM followed by survival selection. It is biased, as explained in my "Life's Manifest" and elaborated in my posts about the role of culture in evolution.

5) "Humans have a very complex history from traveling around the globe, and the human genome is also highly structured, making it complicated and difficult to work with, he said."

- The human genome, like all other genomes, is complicated, the genome being a multi-genes organism, an organism that consists of a cooperative commune of the smaller Earth's primal organisms, namely of the genes.

6)"Adaptation becomes widespread in the population very quickly," Petrov said. "Whereas neutral random mutation doesn't and would not have the selective sweep signature."

- Bravo. This happens to be a correct statement. Random mutations are mechanical accidents that the organism may or may not overcome to survive.


I stop here. No patience nor interest to continue picking at each of the following paras. Just sadly frustrated at The Sad State Of Life Sciences In 2009...


[b]B. PS: On Cosmic Energy And Mass Evolutions[/b]

As mass is just another face of energy it is commonsensible to regard not only life, but mass in general, as a format of temporarily constrained energy.

It therefore ensues that whereas the expanding cosmic constructs, the galaxies clusters, are - overall - continuously converting their original pre-inflation mass back to energy, the overall evolution within them, within the clusters, is in the opposite direction, temporarily constrained energy packages are precariuosly forming and "doing best" to survive as long as "possible"...


Respectfully yours,

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/1981.page http://www.the-scientist.com/community/posts/preList/122/1981.page GMT [u]Humanity Does Not Need Ace Communicators And Politicians.[/b][/u]


[b]I. Science needs ace communicators and politicians [/b]
http://www.sciencenews.org/view/generic/id/42644/title/Science_needs_ace_communicators_and_politicians_


[b]II. SCM, Science Creed Manifest (June 5 2003)[/b]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=142

SCM is a suggested international online educational program for promoting rational, science-based , over the present virtual-reality and faith-belief based, civilizations.

From: Dov Henis
Sent: Saturday, July 12, 2003
To: few prominent scientists (USA and Europe)
Subject: May this project be of interest to you?

May the project outlined below be of interest to you?

I do not seek financial gain/involvement in the proposed project. I simply posit that it warrants serious consideration...

Dov Henis
Hod-HaSharon, Israel
(the message was not acknowledged...)

[b]III. SCM PROJECT OUTLINE [/b]

[b]A.[/b] Extend my brief article at http://www.biobitfield.com/henis/abc_of_life.html to a Scientist Creed Manifest (SCM) urging tolerance and cooperation between all human communities on Earth. The SCM will comprise the following main themes, written in very brief format and in plainest non-professional language, yet scientifically updated :

(1) Description of Earth’s position in our galaxy, of Milky Way galaxy and its position in the cosmos, and of the origin and state of the cosmos.

(2) Inter-relationship of genomes of all Earth organisms with reference to comparative genomics and to history of Earth’s life evolution.

(3) All phenomena of life are fractal, from in-cell to comprehensive total Earth life, including all aspects of all human societies.

(4) Life is a "bubble of energy" system, initiated by energy, collects and stores energy, in a direction opposite the universal thermodynamic drive towards a state of ever dissipating-diluting energy.

(5) The emergence of human culture and civilization is a Life evolutionary revolution similar to the emergence of cells, with the novelties that culture functions for Humans as protein toolings function for genes-genomes , and that humans modify their circumstances according to their needs rather than become adopted to changing circumstances.

[b]B.[/b] A Scientist Creed Manifest might become a germinating and growing seed of promotion of worldwide tolerance and cooperation between communities:

1. “Scientists” are persons learned in science or investigating scientifically.
“Scientism” is a method or doctrine characteristic of scientists, or the proposition that methods of natural sciences should be used in all areas of investigation.

2. If all “scientists” would have embraced “scientism” and thus be “truly scientific” most scientists would find themselves sharing similar opinions or attitudes in regards to most matters or issues. However, the fact is that “scientists” are not apart from non-scientists in regards to opinions or attitudes about a host of matters or issues; together with non-scientists they comprise disagreeing or even hostile groups, especially in most opinion- or attitude-groups regarding social, moral, ethical or religious issues.

3. The two main reasons for this situation are (a) that social, moral, ethical, religious and other humanistic issues are, unlike physical matters, not considered scientific thus not analyzed nor assessed and treated scientifically, and (b) that many or most scientists have not adopted scientism concurrently with acquisition of various levels of technical expertise in the field(s) of their interest.

4. I posit (a) that many or most scientists may be persuaded that each and all humanistic matters and issues are, for humans and for human societies, natural sciences that are functional for humans in the manner that intra-and inter-cell proteinaceous accessories are functional for cellularized genomes, and (b) that scientists embracing and practicing scientism would inevitably hold and share similar opinions or attitudes about humanistic matters and issues, and/or otherwise would not be hostile towards others holding opinions or attitudes different than theirs.

[b]C.[/b] The SCM will be a continuous cooperative project of the worldwide scientific community. Consequent to completion of its first draft it will be updated once a year:

1. Its reason, purpose, scope and format will be presented in a dedicated web site, which will be referred to in major scientific printed and electronic networks.

2. Its first draft and its following annual updates will be composed on-line with the assistance of welcome suggestions.

3. Only its on-line editorial staff will be paid; all other contributors, reviewers and peers will serve and function voluntarily.

end

Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407 ]]> http://www.the-scientist.com/community/posts/preList/122/2000.page http://www.the-scientist.com/community/posts/preList/122/2000.page GMT
[b]A. The Scientist, April 2009[/b]

"Disappearing Before Dawn

Gene expression studies are lending support to a new, somewhat counterintuitive hypothesis for why every animal sleeps. KELLY RAE CHI visits the University of Wisconsin-Madison, where scientists are gathering evidence suggesting that we need sleep to prune back synapses, which tend to increase in strength throughout the day."


[b]B. No End Of Passe Sleep Mantra[/b]

A. "Sleep may clear the decks for next day’s learning"
http://www.sciencenews.org/view/generic/id/42456/title/Sleep_may_clear_the_decks_for_next_day%E2%80%99s_learning
Two separate studies suggest that sleep reduces connections between neurons in fruit flies’ brains.

B. "Missing piece of plant clock found", about "the underlying biochemical mechanisms that control plant clocks". 2009 Passe Mantra.
http://www.physorg.com/news156087384.html

C. No End Of Passe Sleep Mantra

Future research reports will re-affirm, in sophisticated sciencelingo, that the rooster indeed brings on sunrise, or that Gazania flowers switch the sun on and off.

It's about time to understand the origin and function of sleep. There is no "biochemical mechanisms that control bio-clocks". Bio-clocks are products of the innate active-sleep pattern of genes and genomes, parents of all Earth's Life, since in their days of genesis and early evolution direct sunlight was the only source of energy in pre-metabolism Earth life. Melatonin and some proteins are dark-and-light que signals evolved by later monocellular communities, pre-multicellular organisms, for timing intercells clean-up and maintenance processes when intracell genes-genome processes are inactive.


Dov Henis
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1
(Comments From The 22nd Century)]]> http://www.the-scientist.com/community/posts/preList/122/2003.page http://www.the-scientist.com/community/posts/preList/122/2003.page GMT
[b]
A. "Out of Our Heads: Why You Are Not Your Brain, and Other Lessons from the Biology of Consciousness"[/b] by Alva Noe
http://www.sciencenews.org/view/generic/id/42642/title/Book_Review_Out_of_Our_Heads_Why_You_Are_Not_Your_Brain%2C_and_Other_Lessons_from_the_Biology_of_Consciousness_by_Alva_No%C3%AB
Review by Bruce Bower


[b]B. "Memory, Sentience and Consciousness"[/b]
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=174

As gravity is THE manifestation of the onset of the cosmic inflation cataclysm and consequent universe evolution, so sentience is the manifestation of the onset of consciousness and its consequent neural system evolution.

My definitions, from Merriam-Webster:

Sentience = state of elementary or undifferenciated consciousness as distinguished from perception and thought.

Consciousness = the quality or state of being aware especially of something within oneself and/or of an external object, state, or fact.

I suggest that ALL forms of life possess the attribute of sentience, and that from the base towards the most evolved life forms sentience has been evolving into ever more complex form, consciousness.


[b]C. "Life Is Simpler Than They Tell Us"[/b]
http://www.articlesbase.com/science-articles/life-is-simpler-than-they-tell-us-817144.html

Evolution of Earth life:
Genes to Genomes to Monocellular to Multicellular Organisms;
Direct Sunlight Only To Metabolic Energy, Too;
Triptophan To Serotonin To Melatonin To Neural System.

Now we can appreciate the fractal nature of life's evolution. It is ever-continuous ever-enhanced ever-complexed cooperation. Now we can understand why, and grosso modo how, all the organs and processes and signals found in multicelled organisms have their origins in the monocells communities. And this includes the functions of serotonin and melatonin and, yes, the evolution of neural cells and the neural systems with their intricate cellular outer-membrane shapes and functionings and with their high energy consumption requirements.


[b]D. "Life And Culture Are Virtual Realities"[/b]
http://www.articlesbase.com/science-articles/life-and-culture-are-virtual-realities-794583.html

Culture is the totality of ways of the organisms' dealing with (reaction to, manipulation of, exploitation of) its environment. Culture is a biological entity selected for survival of the genome as means of extending its exploitation capabilities of the out-of-cell circumstances, consequent to the earlier evolution and selection of the genome's organ, its outermost cell membrane, for controlling the inside-of-cell genes'-commune environmental circumstances.

Culture is the ubiqitous biological entity that drives Earth life evolution, by imprinting genetics, by continuously modifying genes' expressions.

"Spiritual matters" are virtual reality affairs. They are feasible only for living organisms that have a culture, i.e. that have a pattern of sensings and reactions to the sensings. Genes, and therefore also genomes, are organisms and display virtual reality phenomena, therefore also multicelled organisms,including humans, display such "spiritual" phenomena.


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/2007.page http://www.the-scientist.com/community/posts/preList/122/2007.page GMT

[b]A. "Shared Differences"[/b]
http://www.sciencenews.org/view/feature/id/42620/title/Shared_Differences
The architecture of our genomes is anything but basic.


[b]B. From[/b] http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1&p=401

- "Science Must Be Rescued From Its Guilds", from its host of technicians, politicians and business entrepreneurs.

- "The Evolutionary 'Role' Of Gene Variants, Of Genes And Human Conceit, And Of Inadequate Comprehension".

- "On "Social Genes" And More 'Pseudosophisticated Gibberish".

- And "CNV, Professional Cataract And Verbiage"


[b]C. Views Differences On Genomes Differences,[/b]

[i]on CNV, Copy Number Variation, and on cfv, community family variation[/i]:

CNV is about ORGANISMS, Genes, and about their communal associations, Genomes, and about the state of these organisms and their communes as they are always undergoing evolution.

They have been and are undergoing Darwinian evolution since they have phased, due to then prevailing energetic circumstances, from chemical olygomers into prolyferous genes...

"Design by genes" does not start with the individual genes, the prime organisms. It atarts with their in-cell community association, with the second level organisms, the genomes. It starts with their Culture, with the reaction-manipulation-adaptation they select for surviving in their circumstances. This selection info is fed back to the genes, who consequently select their specific capabilities-expressions accordingly.


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/2021.page http://www.the-scientist.com/community/posts/preList/122/2021.page GMT

[b]A. "New study yields clue to how stem cells form"[/b]
http://www.physorg.com/news159106629.html


[b]B. From "What Makes a Stem Cell a Stem Cell?"[/b]
http://www.genomenewsnetwork.org/articles/10_02/stem_cells.shtml

- A stem cell, by definition, can renew itself and can generate myriad types of specialized cells. But the specific genes that confer these properties remain unknown.

- the Harvard researchers propose several essential attributes that they believe underlie the stem cell's ability to reproduce itself and to generate different types of specialized cells. Key among these is the ability to resist stress from the environment by activating enzymes that repair DNA and detoxify cells. Stem cells also express genes important in regulating the cell cycle and in helping cells to communicate

- It may be some time, however, before researchers fully understand what constitutes "stemness". According to some researchers, genomic analyses may be yielding too much information.


[b]C. So, again, Who-What Is The Stemness In Stem Cells?[/b]

The stemness is a capability-property of the stem-genome. There are no "genes that confer stemness properties" on the innate-virgin stem genome, on the not-yet ever task-committed genome.

And both the genome and its communal genes membership are organisms. Plain and simple and obviously commonsensical.

And in order to confirm stemability on a genome that has already been task-committed it is necesary to uncommit it.

Dov Henis Sep. 2, 2008
http://www.sciencenews.org/view/generic/id/35776/title/Stem_cells,_show_your_face

Dov Henis Oct. 2, 2008
http://www.sciencenews.org/view/generic/id/36881/title/Safer_creation_of_stem_cells_

Yes. Genes Are Organisms.

DNA (and RNA) genes are organisms. RNA toolings of DNA genes were pre-DNA archaic genes, now serving as tools-organisms. And some proteins are cues for past-programmed genes' expressions.

It is necessary to overcome a reflective resistance to conceive certain polymers as living, organisms. However, the plain simple fact of life is that genes are organisms, the primal organisms of Earth, the LIFE of Earth. All other organisms, regardless of complexity and including us, evolve and live temporarily to promote and maintain the genes, to promote and maintain the temporary store of constrained energy at Earth's biosphere.


[b]D. And Earth's biosphere came into being and exists within the Evolution of Cosmic Energy And Mass[/b]

As mass is just another face of energy it is commonsensible to regard not only life, but mass in general, as a format of temporarily constrained energy.

It therefore ensues that whereas the expanding cosmic constructs, the galaxies clusters, are - overall - continuously converting "their share" of original pre-inflation mass back to energy, the overall evolution within them, within the clusters, is in the opposite direction, temporarily constrained energy packages are precariuosly forming and "doing best" to survive as long as "possible"...


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578
EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407 ]]> http://www.the-scientist.com/community/posts/preList/122/2067.page http://www.the-scientist.com/community/posts/preList/122/2067.page GMT

[b]A. "Antarctic ecosystem holds unusual microbes"[/b]
http://www.sciencenews.org/view/generic/id/42853/title/Antarctic_ecosystem_holds__unusual_microbes
Long isolated deep under a glacier, life thrives in dark, salty water by breathing iron and eating sulfates.


[b]B. From "Who-What Is The Stemness In Stem Cells"[/b]
http://www.the-scientist.com/community/posts/list/140/122.page#2067

A planet's biosphere comes into being and exists, within the Evolution of Cosmic Energy-Mass.

As mass is just another face-form of energy it is commonsensible to regard life, and mass in general, as a format of temporarily constrained energy.

The expanding cosmic constructs, the galaxies clusters, are - overall - continuously converting "their share" of original pre-inflation mass back to energy. As cosmic expansion continues the mass-contents of the clusters decreases.

However, within the clusters the overall evolution is in the opposite direction. Temporarily constrained energy packages, such as mass or black holes or life, are forming and "doing best" to survive as long as "possible"...


[b]C. From "Life's Manifest"[/b]
http://www.the-scientist.com/community/posts/list/112.page#578

Life: 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in a planet's biosphere.

Organism: a temporary self-replicable constrained-energy genetic system that supports and maintains a planet's biosphere by maintenance of genes.


Dov Henis
(Comments From The 22nd Century)
Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/2078.page http://www.the-scientist.com/community/posts/preList/122/2078.page GMT

[b]A. "Smallest exoplanet yet is found"[/b]
http://www.sciencenews.org/view/generic/id/43038/title/Smallest_exoplanet_yet_is_found
Finding a planet just under twice Earth's size puts astronomers closer to discovering an Earth counterpart.


[b]B. What is "an Earth counterpart"?[/b]

An "Earth counterpart" may be either a still "pre-lifed" or an already "bio-sphered" planet.

The features that would render a pre-lifed planet a pre-lifed Earth counterpart would include the environmental and compositional parameters of the 4.6 BYA Earth.

The features that would render a bio-sphered planet a bio-sphered Earth counterpart would include a bio-sphere comprising the Planet's primal organisms, its genes, and the chemical constituents of their evolved organisms, where:

[i]Organism[/i] = a self-replicable temporary constrained-energy genetic system that supports and maintains a planet's biosphere by maintenance of its genes.


Dov Henis
(comments from the 22nd century)
"Life's Manifest"
http://www.the-scientist.com/community/posts/list/112.page#578]]> http://www.the-scientist.com/community/posts/preList/122/2117.page http://www.the-scientist.com/community/posts/preList/122/2117.page GMT E. coli
Joined: May/01/2009 06:02:08
Messages: 1
Online [/quote]

I'm gratified and glad to have just been reborn...

Dov Henis

PS: And I would be glad to have my ID changed into the above ID DovTS1019153]]> http://www.the-scientist.com/community/posts/preList/122/2118.page http://www.the-scientist.com/community/posts/preList/122/2118.page GMT [b]Science Budgets Look Rosy, AAAS Finds, May 1st 2009 [/b]

[b]A. AAAS considers present science budgets rosy, [/b]
http://www.sciencenews.org/view/generic/id/43402/title/Science_budgets_look_rosy%2C_AAAS_finds
"The president and Congress have collaborated in targeting substantial increases “Unprecedented” for federal investments in R&D in Science and Engineering fields this year."

[b]B. Are matters bad now because S&E budgets have been inadequate?[/b]

Have inadequate budgets deteriorated or collapsed all our recent affairs? Did a shortage of money bring our world to a grinding slowdown?

Witness the May 2009 sad states of our foreign affairs, of our economy, social and education affairs and of our basic/life-societal-related science fields. Have they deteriorated or collapsed due to inadequate budgets? And will added fresh money and higher budgets correct-improve the state of affairs that have deteriorated?

[b]C. It is our 20th century "technology culture" that deteriorated and collapsed,[/b] and not due to low budgets.

Elementary. Has any joint public-sciense study been commissioned, conducted and its analysis published of how-why the collapse evolved? And has any joint public-science group studied the analysis and suggested-recommended cultural modifications?

Why and how might higher S&E budgets rescue us and place us on a different, promising course?


Wondering,

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/2134.page http://www.the-scientist.com/community/posts/preList/122/2134.page GMT [b]Read All About It! Unbelievable!
The Wheel Is Invented!
Living And Non-living Matter Follow Same Rules?[/b]


[b]A. Can Living And Non-living Follow Same Rules?[/b] Unifying The Animate And Inanimate Designs Of Nature
http://www.sciencedaily.com/releases/2009/04/090428103104.htm


[b]B. "22nd Century Conception Of Unified Field Theory And Evolution"[/b]

1. EVOLUTION Beyond Darwin 200
http://www.physforum.com/index.php?showtopic=14988&st=405&#entry396201
http://www.the-scientist.com/community/posts/list/100/122.page#1407

2. The following brief essays present the 22nd century comprehension of evolution. They preserve Darwin's name in reference to Life Evolution in respect and appreciation of Darwin's promotion of the concept of evolution in life.

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page

Life And Darwinian Evolution, 21st Century Comprehension
http://www.the-scientist.com/community/posts/list/112.page

Rethink Unified Field Theory And Evolution
http://www.the-scientist.com/community/posts/list/60/122.page#982


[b]C. On Cosmic Energy And Mass Evolutions[/b]
http://www.physforum.com/index.php?showtopic=25398&st=15&#entry408520
http://www.physforum.com/index.php?showtopic=25437&st=0&#entry408242

As mass is just another face of energy it is commonsensible to regard not only life, but mass in general, as a format of temporarily constrained energy.

It therefore ensues that whereas the expanding cosmic constructs, the galaxies clusters, are - overall - continuously converting "their share" of original pre-inflation mass back to energy, the overall evolution WITHIN them, within the clusters, is in the opposite direction, temporarily constrained energy packages such as black holes, biospheres and other energy-storing-mass-formats are precariuosly forming and "doing best" to survive as long as "possible"...


Respectfully yours,

Dov Henis
(Comments From The 22nd Century)]]> http://www.the-scientist.com/community/posts/preList/122/2187.page http://www.the-scientist.com/community/posts/preList/122/2187.page GMT Researchers Confirm Science Mantra [/b]

[u][b]"Now we see that genetic diversity goes along with diverse culture"[/b][/u]
[b]What A Thrilling Fresh Discovery![/b]


From [b]"Expansive genetic diversity in Africa revealed"[/b]

http://www.sciencenews.org/view/generic/id/43377/title/Expansive_genetic_diversity_in_Africa_revealed

Largest genetic study of African populations yields clues about the origin of modern humans and the ancestry of African-Americans

- Until now, most genetic studies have used data from just a few African groups that were assumed to reflect Africa’s genetic diversity. But the new research shows that “no single African population is representative of the diversity of the continent,” says study coauthor Sarah Tishkoff of the University of Pennsylvania in Philadelphia. [i](Unbelievably profond scientific observation-statement. Dov Henis)[/i]

- The team found that different African populations had differences in their gene sequences. “We knew that African populations were diverse in culture, art, religious ideas. Now we see that genetic diversity goes along these same lines,” comments Roy King of Stanford School of Medicine.
[i](Would you have believed this thrilling fresh discovery? Dov Henis)[/i]

- The study is a good starting point, the researchers say, hoping to provide a framework for others to build on... [i](To keep piling more and more pseudoscientific gibberish. Dov Henis)[/i]

Dov Henis
(Comments From The 22nd Century)

http://www.articlesbase.com/science-articles/genome-linked-with-culture-812433.html

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

EVOLUTION Beyond Darwin 200
http://www.the-scientist.com/community/posts/list/100/122.page#1407

[b]PS1: [/b]

I can't get over it!

Those "scientists"-"researchers" planned their "research" on the basis of a pre-Copernicus mantra according to which genetics drive-mold culture. They carried out their "research" and drew their conclusions and have visions of expanding the "research" - all in accordance with this mantra...

What's happening in "science" nowadays? Today's "science" is not what science used to be when it was science...

Wondering,

Dov Henis

[b]PS2:[/b]

"Those "scientists"-"researchers" planned their "research" on the basis of a pre-Copernicus mantra according to which genetics drive-mold culture".

I don't want to expand on this, but BTW this mantra, even if ignorantly and unwittingly, is the foundation mantra of racism...

Sadly,

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/2215.page http://www.the-scientist.com/community/posts/preList/122/2215.page GMT [b]Brief Deep Sleeps With Drowsiness And Muscle Power Loss Hallucinations
Linked To Immune system[/b]


[b]A. Narcolepsy linked to immune system[/b]
http://www.sciencenews.org/view/generic/id/43455/title/Narcolepsy_linked_to_immune_system
Genome association study finds a second connection between the sleep disorder and the body's disease-fighting apparatus


[b]B. Dopamine Imbalance: Technology Or Science?[/b] (Dov Henis, 9 Aug 2008)
http://www.articlesbase.com/health-articles/all-about-parkinsons-disease-dopamine-levels-427763.html

1) Dopamine imbalance triggers Parkinson's disease and drug addiction, two opposite diseases
http://www.eurekalert.org/pub_releases/2008-08/nu-wdf080808.php

"...explained the phenomenon using the analogy of a car..."

2) The genome is an organism, not a contrivance

I suggest, again and again, that effects of cell's environments on its functionality be considered and assessed with comprehension that the OCM, the multifunctional Outer Cell Membrane, is but an evolved organ of the organism that lives and functions within it, the living team, the genome.

The genome is a multigenes organism consisting of a cooperative commune of its interdependent member genes. Each of its members has its own constitutional-functional background history, and its own tolerance-reaction to environments-signals reaching it via the functional membranes around the genome. Decisions are made within the OCM most probably as conjectured in

http://www.the-scientist.com/community/posts/list/122.page#373

Planning and assessment of research work in life sciences, especially in cell level matters, should take this recent comprehension into account...

One day, maybe soon, science will arrive at the comprehension of life and the nature of genes-genome...


[b]C. Circadian Rhythm-Metabolism Link Is Self-Explanatory[/b] (Dov Henis, 23 Dec 2008)
http://www.physorg.com/news136122147.html

1) Circadian rhythm-metabolism link discovered
http://esciencenews.com/articles/2008/07/24/circadian.rhythm.metabolism.link.discovered

The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process.

2) Circadian-rhythm is the genes' innate rest time,

which - together with life's chirality - are the earliest evidences of Darwinian life evolution, the evolution of the primal, 1st stratum, Earth organisms, the genes.


[b]D. From "SC displaced more easily when off-duty" [/b](Dov Henis 10 Oct 2008)
http://www.the-scientist.com/blog/display/55081/

"It is unclear why the stem cells leave their niche during a patient's time of rest"?

SC are more easily displaced during the organism's rest time simply because their genes and genome are off-duty then, part of the duty is being on-call at the specific site where it is:


[b]E. Life's Chirality And Circadian Rhythm, Evidence Of Updated Darwinian Evolution[/b]

1) Updated life's concepts:
http://www.the-scientist.com/community/posts/list/20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd
stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis, on life's day one.

- Life's evolution is not random. It is biased, driven by organisms' cultures.


2) Earliest evidences of updated Darwinian evolution:

- Life's chirality
http://www.the-scientist.com/community/posts/list/122.page#387
http://www.physforum.com/index.php?showtopic=14988&st=180&#entry327715

- Circadian rhythm
http://forum.physorg.com/index.php?showtopic=14988&st=135&#entry301299


[b]F. Significance Of Hour-Timing In Medical Treatment [/b](Dov Henis,30 March 2009)

1) Vaccine could protect against virus that causes birth defects
http://www.sciencenews.org/index/generic/activity/view/id/41874/title/Vaccine_could_protect_against_virus_that_causes_birth_defects

An experimental vaccine is shown effective half the time it's administered in stopping cytomegalovirus infection in women in their child-bearing years.

No vaccine currently exists for cytomegalovirus, which can cause birth defects when it infects a pregnant woman. Because of this risk, vaccine researchers have targeted the virus for decades without any clear benefit until now.

This is the first vaccine that really shows prevention from infection with cytomegalovirus.

2) Medication's efficiency rate might differ with hour-of-day of administration
http://www.articlesbase.com/science-articles/life-is-simpler-than-they-tell-us-817144.html

I suggest that the efficiency rate of the vaccine might differ depending on the hour of day at which it is administered. This since the genome-genes of night-sleepers are inactive mostly circa 2AM and the levels of serotonin-melatonine are highest then, signalling a call for intercell maintenance time.


[b]Epilogue:[/b]
Circadian rhythm-metabolism link is self-explanatory, and new "findings" are not required for suggesting that proper sleep-and-diet could help maintain or rebuild organism's "equilibrium" and for explaining why lack of proper rest, or disruption in our normal sleep patterns, is known to cause several unhealthy things in us and accelerate our aging process.


Suggesting,

Dov Henis
(Comments From The 22nd Century) ]]> http://www.the-scientist.com/community/posts/preList/122/2274.page http://www.the-scientist.com/community/posts/preList/122/2274.page GMT [u][b]2010 "Science" Budgets, Another Delusion[/b][/u]
[b]"Science" Share In Economy Collapse Evolution Not Assessed[/b]


[b]A. [/b]"Money Printing Will NOT Cure The Technology Culture Greed Cancer" and
"Real And Virtual Energy, And Keynesian Salvation Prospects", at
http://www.articlesbase.com/science-articles/economy-collapse-cure-delusion-799133.html


[b]B. [/b]"Science" Share In Economy Collapse Evolution Not Assessed

It is not only what "Science" has been doing, but - much more important - what it has not been doing, what it neglected or avoided within the evolution of the 20th century Technology Culture.

IMO the AAAS has turned itself and other "Science-Organizations-Establishments" into essentially an American (and some international affiliates) guild-union of workers in Technology-Related industries, academies and organizations, and has turned Science into a "Popular Companion Religion" in the service of the 20th century Technology Culture. It has turned peer review into a tool of corrupt “Subversive Activities Control Board”, where the corruption is not inherent in the tool, but in the nature of the Science Establishment and in the characteristics of obsequious members and functionaries.

Not one in the "Science Establishments" has raised the question where were the "Scientists" (what-who are they?) during the years in which the Technology Culture has been reigning supreme and has been evolving into its recent collapse. "Scientists" (what-who are they?) obviously think that the Science Establishment had-has no share whatsoever in the evolution of the collapse. Most "Scientists" (what-who are they?) selfrighteously think that increase of "science-technology budget" is essential for repairing the collapse, and imply that the collapse might have been prevented if their budgets were higher...

The disappointment is that the "Science Establishments" have not examined their own contribution to the collapse, their own 100-years continuous deterioration into servents of the Technology Culture, and into the ludicruos inflated self-esteem image that many of them have rightly earned and project today.


Sadly and respectfully,

Dov Henis]]> http://www.the-scientist.com/community/posts/preList/122/2306.page http://www.the-scientist.com/community/posts/preList/122/2306.page GMT [b]Monocells' Community Culture to Multicellular Organisms' Neural System[/b]

[b]A. "Identification of a key molecular pathway required for brain neural circuit formation"[/b]
http://www.eurekalert.org/pub_releases/2009-05/idrc-ioa051509.php


[b]B. From "Life Is Simpler Than They Tell Us"[/b]

http://www.articlesbase.com/science-articles/life-is-simpler-than-they-tell-us-817144.html

Evolution:
Genes to Genomes to Monocellular to Multicellular Organisms;
Direct Sunlight to Metabolic Energy, Too;
Triptophan to Serotonin to Melatonin to Neural System.

Monocellular Communities to Multicellular Organisms, Monocells' Communities Culture to Multicellular Organisms' Neural System

Dov Henis
(Comments From The 22nd Century)

Life's Manifest
http://www.the-scientist.com/community/posts/list/112.page#578

EVOLUTION Beyond Darwin 200
http://www.the-scientist.com/community/posts/list/100/122.page#1407]]> http://www.the-scientist.com/community/posts/preList/122/2316.page http://www.the-scientist.com/community/posts/preList/122/2316.page GMT
[i]Recapitulation of some earlier notes on the
Scientific Comprehension Of The Origin, Drive, Nature And Purpose Of Life [/i]

[b]A. Uniqueness Of science among human artifacts [/b]

ALL aspects of our culture are, of course, anthropoartifacts, including science. Yet among those artifacts science has a distinct uniqueness for us.

During the recent several centuries in the course of human history humans have been developing science at an accelerating rate as a provider of convincing, ever closer approaching, approximate models of the real world.


[b]B. Origin and nature of life[/b]

Astronomically there are two "physics", a "classical physics" system of and between galactic clusters, and a "quantum physics" system WITHIN the galactic clusters.

The onset of big-bang's inflation started gravity, followed by formation of galactic clusters that behave as Newtonian bodies while continuously reconverting their shares of pre-inflation masses back to energy, that continuously fuels their ongoing expansion, and of endless intertwined evolutions WITHIN the clusters in attempts to resist this reconversion.

As mass is just another face of energy it is commonsensible to regard not only life, but mass in general, as a format of temporarily constrained energy.

It therefore ensues that whereas the in-space expanding cosmic constructs, the galaxies clusters, are - overall - continuously converting their original pre-inflation mass back to energy, the overall evolution WITHIN them, within the clusters, is in the opposite direction, temporarily constrained energy packages such as black holes and biospheres and other energy-storing mass-formats are precariuosly forming and "doing best" to survive as long as "possible"...


[b]C. The drive and nature of Earth life [/b]

Earth life Genesis, formation of the first genes, was a phenomenon of serendipitous occurrence, in a supportive environment, of 'favourably-coursed' energy potential between in-coming sun's radiation and polymerizing-precipitating RNA-related oligomeric configuration.

The drive of Earth life and of its evolution is to enhance the functionality and survivability of Earth's genes, in order to maintain and enhance Earth-biosphere's temporary constrained energy storage and to maintain the biosphere BIO as long as possible.

It is the genes, life's prime strata organisms, that evolve, and the evolution of genomes, the 2nd stratum of life, and of the 3rd life stratum cellular organisms, is an interenhancing consequence of their genes' evolution.


[b]D. The formation of Earth life [/b]

[i]Earth Life:[/i] 1. a format of temporarily constrained energy, retained in temporary constrained genetic energy packages in forms of genes, genomes and organisms 2. a real virtual affair that pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere.

[i]Earth organism:[/i] a temporary self-replicable constrained-energy genetic system that supports and maintains Earth's biosphere by proliferating and maintenance of genes.

[i]Gene:[/i] the primal Earth's organism. (1st stratum organism)

[i]Genome:[/i] a multigenes organism consisting of a cooperative commune of its member genes. (2nd stratum organism)

[i]Cellular organisms:[/i] mono- or multi-celled Earth organisms. (3rd stratum organism)


[b]E. Update of underlying life sciences conception is thus feasible [/b]

- First were independent individual genes, Earth's primal organisms.

- Genes aggregated cooperatively into genomes, multigenes organisms, with genomes' organs.

- Simultaneously or consequently genomes evolved protective-functional membranes, organs.

- Then followed cellular organisms, with a variety of outer-cell membrane shapes and
functionalities.

This conception is a scientific, NOT TECHNICAL, life-science innovation.

It is tomorrow's comprehension of life and of its evolution.

IT IS FRAUGHT WITH INTRIGUING DARWINIAN EVOLUTION IMPLICATIONS.

IT IS FRAUGHT WITH INTRIGUING TECHNOLOGICAL DEVELOPMENTS POTENTIALS.


[b]F. The purpose of OUR, human, life [/b]

The purpose of OUR life and of its promotion is ours to formulate and set. It derives solely from our cognition.


Suggesting,

Dov Henis
(Comments from 22nd century)
http://profiles.yahoo.com/blog/2SF3CJJM5OU6T27OC4MFQSDYEU?num=5&max=160&start=0
]]> http://www.the-scientist.com/community/posts/preList/122/2321.page http://www.the-scientist.com/community/posts/preList/122/2321.page GMT [u][b]It Is The Lifehood Of Genes That Makes All Organisms Alive[/b][/u]
[b]Are Parts Of Our Humanoid Body Superfluous Junk[/b]


[b]A. "Research team finds important role for junk DNA"[/b]
http://www.princeton.edu/main/news/archive/S24/28/32C04/


[b]B. From "Aging Seen Without The Emperor'S New Clothes"[/b]
http://www.sciencenews.org/index/generic/activity/view/id/37382/title/Old_age_causes_problems_for_gut_cells
http://www.articlesbase.com/science-articles/aging-seen-without-the-emperors-new-clothes-808441.html

Right they are: "Nearly all organisms experience aging". But why "nearly"?

Why doesn't "science" accept the obvious fact that genes are organisms and "experience aging", too?

Not only yeast, worms and people. Also genes and the interdependent-genes-communes, genomes. Theye are both organisms. They are alive. It is their "lifehood" that makes us and all life forms "alive".

By plain common sense - my favorite scientific approach - they should also be "experiencing aging"...


[b]C. If it is not the lifehood of genes that makes each and all organisms alive,[/b]

what otherwise makes each and all organisms alive?


Dov Henis
(Comments From The 22nd Century)
Updated Life's Manifest May 2009
http://www.physforum.com/index.php?showtopic=14988&st=495&#entry412704
http://www.the-scientist.com/community/posts/list/140/122.page#2321]]> http://www.the-scientist.com/community/posts/preList/122/2351.page http://www.the-scientist.com/community/posts/preList/122/2351.page GMT [u][b]More On The Lifehood Of Genes[/b][/u]
[b]that makes each and all organisms alive[/b]


[b]A. Two of many examples of cells' pluripotency, genostemness, induction[/b]

- "For blood stem cells, the force is strong"
http://www.sciencenews.org/view/generic/id/43761/title/For_blood_stem_cells%2C_the__force_is_strong
Blood flow boosts production of blood stem cells, two new studies show.

- "New study yields clue to how stem cells form" and "Who-What Is The Stemness In Stem Cells"
http://www.physorg.com/news159106629.html


[b]B. Again, re the stemness in stem cells[/b]

Stemness, pluripotency, is an innate capability-property of the stem-genome. There are no "genes that confer stemness properties" on innate-fresh stem genomes, not-yet task-expression-committed genomes.

Both the genome and its communal genes membership are organisms. Plain and simple and obviously commonsensical. In order to recover pluripotency by an already task-committed genome it is necesary to unccommit it.


[b]C. "Genes to Genomes to Monocellular Organisms to Multicellular Organisms"[/b]
http://www.articlesbase.com/science-articles/life-is-simpler-than-they-tell-us-817144.html

Now we can appreciate the fractal nature of life's evolution. It is ever-continuous ever-enhanced ever-complexed cooperation. Now we can understand why, and grosso modo how, the organs and processes and signals found in multicelled organisms have their historical origins in the life-cultures of monocells communities. And this includes modifying shape of monocells community in response to changed circumstances, functions of serotonin and melatonin and, yes, the evolution of neural cells and the neural systems with their intricate outer-membrane shapes and functions and their high energy consumption requirements.

And this includes also production of fresh genostem cells in monocells communities, in response to arising community needs. And this includes also a variety of means and mechanisms within cells community involved from sensing a need of fresh genostemcells through producing them and directing them to target locations where they are needed and committing them to the specific tasks in response to the new need.


[b]D. In natural life gene's expressions and their modifications are evolutionary matters[/b]

Change of expression is driven by feedback from the dynamics of the culture (mode of behaviour) of their cells community, dictated and directed, selected, by their environmental circumstances. This, of course, is the base fractal rung of the ladder of Darwinian evolution. And this is so because genes are plainly organisms.


[b]E. Why Pavlov smiled in 2008[/b]

http://www.sciencenews.org/index/generic/activity/view/id/40735/title/For_gamblers_brains%2C_almost_counts_

http://www.sciencenews.org/index/feature/activity/view/id/39046/title/Imagination_Medicine

Pavlov demonstrated effecting placebo phenomena in multicelled organisms by manipulation of their drives-reactions. Now placebo and imagination phenomena are demonstrated also in Life's primal organisms, in genes and genomes, in our first stratum and 2nd stratum base organisms. A very good reason for him to smile. What makes this possible? It is possible simply since these are, too, organisms.


[b]F. So, if it is not the lifehood of genes that makes each and all organisms alive,

what otherwise makes each and all organisms alive?[/b]


Dov Henis
(Comments From The 22nd Century)
Updated Life's Manifest May 2009
http://www.physforum.com/index.php?showtopic=14988&st=495&#entry412704
http://www.the-scientist.com/community/posts/list/140/122.page#2321]]> http://www.the-scientist.com/community/posts/preList/122/2365.page http://www.the-scientist.com/community/posts/preList/122/2365.page GMT [u][b]Unbelievably Sensational Finding![/b][/u]


[b]A. Neurons take a break during slow-wave sleep[/b]
http://www.sciencenews.org/view/generic/id/44027/title/Neurons_take_a_break_during__slow-wave_sleep
Electrical markers associated with slow-wave sleep indicate downtime for neurons.


[b]B. Circadian-rhythm is the genes' innate rest time, [/b]
http://www.physforum.com/index.php?showtopic=14988&st=495
http://www.the-scientist.com/community/posts/list/140/122.page#2274

which - together with life's chirality - are the earliest evidences of Darwinian life evolution, the evolution of the primal, 1st stratum, Earth organisms, the genes.


Dov Henis
(Comments From The 22nd Century)

Updated Life's Manifest May 2009
http://www.physforum.com/index.php?showtopic=14988&st=495&#entry412704
http://www.the-scientist.com/community/posts/list/140/122.page#2321]]> http://www.the-scientist.com/community/posts/preList/122/2376.page http://www.the-scientist.com/community/posts/preList/122/2376.page GMT [b]Science? Scientists? Peer Reviewed? [/b]


[b]A. Quotations from "Life on Earth took a licking, kept on ticking"[/b]
http://www.sciencenews.org/view/generic/id/43974/title/Life_on_Earth_took_a_licking%2C_kept_on_ticking
Earth's early organisms may not have had to restart after a long spell of asteroid impacts about 3.9 billion years ago...

- Even if all of the bombardment’s impacts happened at once, life could have survived, Mojzsis notes. “Although we tried to kill everything, we were unable to,” he adds.

- Many of the bombardment’s impacts would have snuffed out any photosynthetic organisms, which depend on light to survive.

- The new study “is a nice piece of work".


[b]B. These statements are about earth's early organisms 3.9 billion years ago?[/b]

Tried to kill everything? photosynthetic organisms?
Search background comprehensions re why "Circadian Rhythm" dominates all life functions, why we sleep. The answer may point out the absurdity of the above statements.


Dov Henis
(Comments From The 22nd Century)
Updated Life's Manifest May 2009
http://www.physforum.com/index.php?showtopic=14988&st=495&#entry412704
http://www.the-scientist.com/community/posts/list/140/122.page#2321]]> http://www.the-scientist.com/community/posts/preList/122/2382.page http://www.the-scientist.com/community/posts/preList/122/2382.page GMT [i](remarks of a self-considered scientist)[/i]


[b]A. Again: Prsdnt Obama deludes himself re the required economy collapse cure.[/b]

It's not just the economy that collapsed. Not just the financial system-policies. It's the 20th century technology culture that collapsed.


[b]B. Again: money printing will not cure the technology culture greed cancer.[/b]
http://www.the-scientist.com/community/posts/list/140/122.page#2306

[i]Scientism[/i] = a doctrine and method characteristic of pre-Technology-Culture-Era scientists, and the proposition that classical scientific doctrine and methods of studying natural sciences should be used in all areas of investigation and of conduct, to societal-cultural-civil affairs. An approach by rational humans seeking an efficient practical, as fair as possible, viable civic framework.

From a scientism perspective it is an exasperating disappointment that the national and international "Science Establishments" have not examined their own contribution to the collapse, their own 100-years obsequious deterioration into servents of the Technology Culture, and into the ludicruos inflated self-esteem image that many of them have rightly earned and project today.


[b]C. And further:[/b] Science and scientism are relevant and involved in ALL aspects of national and international culture and life and thus in all political policies.

Yet basic, non-applied science, since the 18th century Enlightenment the banner of social and societal evolution out of entrenched traditional doctrines and values, has been abandoned in the 20th century and presently barely survives in few institutions. Enlightenment's inherent philosophy and attitudes in regards to individualism, universal human progress and the applications of reason have been squeezed off the western culture highway by the flood of values, attitudes and texture of life of the Technology Culture.


[b]D. And still further: [/b]Prsdnt Obama has been elected to office by and within the 20th century technology culture society, a society that still resists internalizing, accepting, admitting its cultural collapse.

Society not only has not yet internalized its cultural collapse, but is persistently striving against basic rationalism, scientism, to re-invigorate the terminally ill technology culture, its values and its economy.


[b]E. And still more:[/b] about aspects of international political policies

[i]"Western culture"[/i] is the ongoing dynamically evolving science-informed culture, initiated in Western Europe, tin