Upgrade Your Lab to TIRF

By Jeffrey M. Perkel

Why spend six figures on a new total internal reflection fluorescence system when you can upgrade your existing microscope for just $30,000?

Total internal reflection fluorescence (TIRF) microscopy is a method that resolves molecular events specifically at or near the cell surface. Follow this step-by-step guide, complete with pictures, to learn how to upgrade your existing microscope in as little as half an hour.

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Beyond GFP

By Chandra Shekar

Fluorescent repertoire expands with oranges, cherries

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Papers to Watch: Replication factories in action

By The Scientist Staff

Investigators now have experimental evidence that two replication forks diverging from a single origin are held together in space.

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Lipid Rafts' Failure to Launch

By Jill U. Adams

Debating what binds membrane microdomains

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Papers to Watch: Cell division rewinds

By The Scientist Staff

The cell cycle is generally considered a one way ticket to division. Oklahoma Medical Research Foundation scientists recently reversed the process.

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Papers to Watch: Membrane fusion model de-fused

By The Scientist Staff

Researchers have now shown that SNARE complex formation does not automatically lead to membrane fusion.

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Spotlight

The Handbook - A Guide to Fluorescent Probes and Labeling Technologies
Newly revised, The Handbook contains detailed information describing the use of more than 3000 Molecular Probes products for life science research, including extensive data, numerous technical notes, and full-color images of the products in action.
Spotlight

Products for State-of-the-Art Imaging
Products for State-of-the-Art Imaging offers a concise overview of conjugates and reagents for cutting-edge imaging solutions. This eleven-page publication provides details on our full range of Alexa Fluor secondary antibody conjugates (including cross-adsorption data), and describes powerful tools for image optimization-ProLong Gold antifade reagent and Image-iT FX signal enhancer.
Spotlight

Fluorescence Spectraviewer
Now you can plot and compare spectra and check the spectral compatibility for many fluorophores offered by Molecular Probes.
PubMed Articles
Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle.
Eur J Nucl Med Mol Imaging. 2009 Jul 2;
Wang Y, Liu X, Chen L, Cheng D, Rusckowski M, Hnatowich DJ
Fluorescence lifetime imaging microscopy: in vivo application to diagnosis of oral carcinoma.
Opt Lett. 2009 Jul 1; 34(13): 2081-3
Sun Y, Phipps J, Elson DS, Stoy H, Tinling S, Meier J, Poirier B, Chuang FS, Farwell DG, Marcu L
Rac1 Modulates Stimulus-Evoked Ca2+ Release in Neuronal Growth Cones via Parallel Effects on Microtubule/ER Dynamics and ROS Production.
Mol Biol Cell. 2009 Jul 1;
Zhang XF, Forscher P
Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats.
Schizophr Res. 2009 Jun 29;
Gregg JR, Herring NR, Naydenov AV, Hanlin RP, Konradi C
Precise detection of lymph node metastases in mouse rectal cancer by using 5-aminolevulinic acid.
Int J Cancer. 2009 Jun 30;
Murayama Y, Harada Y, Imaizumi K, Dai P, Nakano K, Okamoto K, Otsuji E, Takamatsu T
Evidence for in vivo macrophage mediated tumor uptake of paramagnetic/fluorescent liposomes.
NMR Biomed. 2009 Jun 30;
Castelli DD, Terreno E, Cabella C, Chaabane L, Lanzardo S, Tei L, Visigalli M, Aime S
Imaging the boundaries-innovative tools for microscopy of living cells and real-time imaging.
J Chem Biol. 2008 Nov; 1(1-4): 3-15
Rosivatz E
Investigations on light-induced stress in fluorescence microscopy using nuclear localization of the transcription factor Msn2p as a reporter.
FEMS Yeast Res. 2009 Jun 3;
Logg K, Bodvard K, Blomberg A, Käll M
Enhancement of confocal microscopy images using Mueller-matrix polarimetry.
J Microsc. 2009 Jul; 235(1): 84-93
Bueno JM, Cookson CJ, Kisilak ML, Campbell MC
Halton sampling for autofocus.
J Microsc. 2009 Jul; 235(1): 50-8
Pengo T, Muñoz-Barrutia A, Ortiz-De-Solórzano C
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