Ulcer healing with local gene therapy :The Scientist [1/11/2001]

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RESEARCH ROUND-UP

Ulcer healing with local gene therapy

Gene therapy with a single local injection of naked DNA encoding VEGF and angiopoietin-1 improves gastric ulcer healing.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011101-03

1 November 2001

The mechanism of gastroduodenal ulcer healing involves angiogenesis but the exact roles of molecules such as vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) in this process remain unclear. In November Gastroenterology, Michael Jones and colleagues from University of California, Irvine, California show that gene therapy with a single local injection of naked DNA encoding VEGF and angiopoietin-1 can accelerate ulcer healing.


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