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Toll road to mast cell activation
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020522-02
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Toll-like receptor 2 (TLR2) and TLR4 are pattern-recognition molecules with an important role in the early innate immune response to microbial challenge, but their presence on mast cells remains unexplained. In 15 May Journal of Clinical Investigation, Volaluck Supajatura and colleagues from Juntendo University School of Medicine, Tokyo, Japan, show that direct activation of mast cells via TLR2 or TLR4 by respective microligands contributes to innate and allergic immune responses (J Clin Invest 2002, 109:1351-1359).
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