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Thiazolidinediones cause weight gain
News from The Scientist 2002, 3(1):20020924-02
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Treatment of type 2 diabetes with thiazolidinediones can lead to excess weight gain, but the mechanisms behind this change have been unclear. In September 23 Nature Medicine, Hong-Ping Guan and colleagues at University of Pennsylvania School of Medicine, Philadelphia, US, show that TZDs activate a futile metabolic cycle in adipocytes which cause the weight gain (Nature Medicine, DOI 10.1038/nm780, September 23, 2002).
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