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Antifungal antisense
News from The Scientist 2003, 4(1):20030129-01 doi:10.1186/20030129-01
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Candida albicans infection is a significant complication in the treatment of immunocompromized patients. Novel treatment strategies have included targeting fungal pathogen RNA with antisense oligonucleotides. A number of promising compounds have been identified, but little has been known about the mechanisms of oligonucleotide uptake into fungi. In the January 29 early edition of Proceedings of the National Academy of Sciences, Matthew D. Disney and colleagues at the University of Rochester, New York, USA, show that oligonucleotides can accumulate in C. albicans and inhibit its growth (PNAS, DOI:10.1073/pnas.0337462100, January 27, 2003).
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