Generating polarity :The Scientist [31/1/2003]

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by Jonathan Weitzman

RESEARCH ROUND-UP

Generating polarity

Email: Jonathan Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2003, 4(1):20030131-02 doi:10.1186/20030131-02

Published

31 January 2003

Two studies, published online this week, demonstrate the importance of Cdc42, a Rho-type guanosine triphosphatase (GTPase), in cell polarization. In the January 30 Sciencexpress, Roland Wedlich-Soldner and colleagues used a fusion protein of green fluorescent protein linked to a constitutively activated form of Cdc42 in yeast cells (Sciencexpress, DOI:10.1126/science.1080944, 30 January, 2003). They observed that F-actin and actinomyosin-directed vesicle transport were essential for the establishment and maintenance of Cdc42-induced polar cap formation in growth-arrested cells.


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