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Antibodies - two for one
Email: Tudor P Toma - t.toma@ic.ac.uk News from The Scientist 2003, 4(1):20030228-02 doi:10.1186/20030228-02
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Antibodies have an exquisite specificity but are also able to cross react with multiple antigens. Specificity is achieved by clonal expansion, but the molecular mechanisms of multispecificity have been unclear. In the February 28 Science, Leo C. James and colleagues at the MRC Centre for Protein Engineering, Cambridge, UK, show that antibody multispecificity can be mediated by conformational diversity of preexisting isomers that can adopt multiple functions and can increase the effective size of the antibody repertoire (Science, 299:1362-1367, February 28, 2003).
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