Neural control of food intake :The Scientist [19/5/2003]

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by Tudor P Toma

RESEARCH ROUND-UP

Neural control of food intake

Email: Tudor P Toma - t.toma@imperial.ac.uk
News from The Scientist 2003, 4(1):20030519-01

Body fat has complex control mechanisms regulated by a hypothalamic lipostatic feedback system. Lipid metabolism in selective hypothalamic neurons may be a primary biochemical sensor for nutrient availability, but the molecular mechanisms involved have been unclear. In the May 19 advanced online Nature Medicine, Silvana Obici and colleagues at the Albert Einstein College of Medicine show that inhibition of hypothalamic carnitine palmitoyltransferase-1 (CPT1) decreases food intake and glucose production (Nature Medicine, DOI:10.1038/nm873, May 18, 2003).


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