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HLA influences AIDS response
Email: Tudor Toma - t.toma@imperial.ac.uk News from The Scientist 2003, 4(1):20030623-02
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Differences in viral strains and host factors influence the incidence and clinical outcome of HIV infection. Among host factors, the HLA class I molecules determine the specificity and repertoire of the immune response, but the precise nature of HLA associations with HIV have been unclear. In the June 22 Nature Medicine, Elizabeth Trachtenberg and colleagues at the Children's Hospital and Research Center at Oakland show that rare HLA supertypes confer protection against HIV disease progression (Nature Medicine, DOI:10.1038/nm893, June 22, 2003).
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