Shields for premature eyes :The Scientist [2/7/2003]

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by Tudor Toma

RESEARCH ROUND-UP

Shields for premature eyes

Email: Tudor Toma - t.toma@imperial.ac.uk
News from The Scientist 2003, 4(1):20030702-01

Published

2 July 2003

Supplemental oxygen is necessary for normal lung development in premature neonates, but oxygen also suppresses VEGF-A expression in the retina, causing retinal vessel damage and retinopathy of prematurity (ROP). The mechanisms responsible for survival of blood vessels in the developing retina have been unclear, but in the July 1 Journal of Clinical Investigation, Shu-Ching Shih and colleagues at Harvard Medical School and Children's Hospital Boston show that selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in ROP (Journal of Clinical Investigation, 112:50–57, July 1, 2003).


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