Rebooting pluripotency :The Scientist [16/7/2003]

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by Cathy Holding

RESEARCH ROUND-UP

Rebooting pluripotency

Email: Cathy Holding - cholding@hgmp.mrc.ac.uk
News from The Scientist 2003, 4(1):20030716-03

Published

16 July 2003

Expression of the transcription factor Oct4, a marker of pluripotency, is a necessary prerequisite for development of both normal and cloned embryos. In the July 15 Current Biology, James Byrne and colleagues at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology report the expression of Oct4 during reprogramming of transferred differentiated nuclei into Xenopus oocytes. Their results indicate a repression of expression of differentiation markers and a rapid and strong induction of the Oct4 transcription factor (Current Biology, 13:1206-1213, July 15, 2003).


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