Signals for malaria infection :The Scientist [19/9/2003]

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by Tudor Toma

RESEARCH ROUND-UP

Signals for malaria infection

Email: Tudor Toma - t.toma@imperial.ac.uk
News from The Scientist 2003, 4(1):20030919-01

Published

19 September 2003

Plasmodium falciparum—the species that causes the most virulent human form of malaria—infects both hepatocytes and mature red blood cells (erythrocytes). The erythrocytic stages are responsible for the symptoms associated with the disease (e.g., fever, headache, and back pain), but the mechanisms involved in malarial infection have been poorly understood. In the September 19 Science, Travis Harrison and colleagues at the Feinberg School of Medicine show that signaling via the erythrocyte β2-adrenergic receptor and Gαs regulates erythrocytic stages of malarial infection across Plasmodium species (Science, 301:1734-1736, September 19, 2003).


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