Botox receptors: identification and inhibition :The Scientist [3/10/2003]

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by Sean Lawler

RESEARCH ROUND-UP

Botox receptors: identification and inhibition

Email: Sean Lawler - slawler@partners.org
News from The Scientist 2003, 4(1):20031003-01

Published

3 October 2003

Clostridial neurotoxins (CNTs)—tetanus and botulinum neurotoxins (BoNTs)—block neurotransmission, causing paralysis and death. Cellular entry of CNTs requires both gangliosides and proteins, and although several binding proteins have been identified, the specific protein associated with CNT internalization has remained unclear. In the September 29 Journal of Cell Biology, Min Dong and colleagues at the University of Wisconsin–Madison demonstrate that the secretory vesicle proteins synaptotagmins (syts) I and II bind and internalize BoNT/B (Journal of Cell Biology, 162:1293-1303 September 29, 2003).


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