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Mice cloned from cancer cell
Email: David Secko - dmsecko@interchange.ubc.ca News from The Scientist 2004, 5(1):20040802-01
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Tumor development involves epigenetic changes, including the activation of oncogenes and the silencing of tumor suppressor genes, but to what extent these epigenetic changes can be reprogrammed is largely unknown. Now, a study in the August 2 Genes and Development reveals that the nuclear transplantation of a cancer cell nucleus into an oocyte can reverse its cancer phenotype and produce embryonic stem cells with developmental potential.
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