Enhancing stem cell transplants :The Scientist [13/8/2004]

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RESEARCH ROUND-UP

Enhancing stem cell transplants

Email: David Secko - dmsecko@interchange.ubc.ca
News from The Scientist 2004, 5(1):20040813-04

Successful transplantation of hematopoietic stem cells (HSCs) requires both the homing and engraftment of stem cells to the bone marrow, two processes that may not be very efficient and force a need for large numbers of HSCs for transplantation. To date, is has been unclear whether these processes can be artificially enhanced. Now, a study in the August 13 Science reveals that the inhibition or genetic deletion of the peptidase CD26 on donor stem cells increases transplantation efficiency, a result that suggests this method may prove useful for the clinical improvement of bone marrow transplants.


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