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Gene fusion identified in prostate cancer
Email: Ishani Ganguli - iganguli@the-scientist.com News from The Scientist 2005, 6(1):20051028-01
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Using a novel bioinformatics approach, researchers found that the majority of prostate cancers carry a specific gene fusion, a common feature of blood cancers but relatively rare in solid tumors, according to this week'sScience. A team led by Arul Chinnaiyan found that in over 75% of prostate cancer samples, the regulatory region of the TMPRSS2 gene is fused to a gene encoding an ETS transcription factor, either ERG or ETV1, causing over-expression of the factor and, in turn, cancerous growth.
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